The present invention generally relates to the transdermal delivery of various compositions. In some aspects, the transdermal delivery may be facilitated by the use of a hostile biophysical environment. One set of embodiments provides a composition for topical delivery comprising ibuprofen and/or an
The present invention generally relates to the transdermal delivery of various compositions. In some aspects, the transdermal delivery may be facilitated by the use of a hostile biophysical environment. One set of embodiments provides a composition for topical delivery comprising ibuprofen and/or an ibuprofen salt, a nitric oxide donor, and optionally, a hostile biophysical environment. In some cases, the composition may be stabilized using a stabilization polymer such as xanthan gum, KELTROL® BT and/or KELTROL® RD; propylene glycol; and a polysorbate surfactant such as Polysorbate 20, which unexpectedly provides temperature stability to the composition, e.g., at elevated temperatures such as at least 40° C. (at least about 104° F.), as compared to compositions lacking one or more of these.
대표청구항▼
1. A composition for topical delivery to the skin of a subject, the composition comprising: an ionic strength of at least about 0.25 M;a stabilization polymer comprising xanthan gum;propylene glycol;a polysorbate surfactant; andibuprofen and/or an ibuprofen salt. 2. The composition of claim 1, where
1. A composition for topical delivery to the skin of a subject, the composition comprising: an ionic strength of at least about 0.25 M;a stabilization polymer comprising xanthan gum;propylene glycol;a polysorbate surfactant; andibuprofen and/or an ibuprofen salt. 2. The composition of claim 1, wherein the composition comprises an ionic salt. 3. The composition of claim 1, wherein the composition comprises sodium chloride. 4. The composition of claim 1, wherein the sodium chloride is present at at least about 5% by weight of the composition. 5. The composition of claim 1, wherein the composition comprises one or more salts selected from the group consisting of choline chloride, magnesium chloride, lithium chloride, and calcium chloride. 6. The composition of claim 1, wherein the composition comprises citric acid. 7. The composition of claim 1, wherein the composition is stable when exposed to a temperature of 40° C. for at least about 4 weeks. 8. The composition of claim 1, wherein the composition is a cream. 9. The composition of claim 1, wherein the composition is a gel. 10. The composition of claim 1, wherein the composition is a lotion. 11. The composition of claim 1, wherein the composition has an ionic strength of at least about 1 M. 12. The composition of claim 1, wherein the composition has a pH of between about 5 and about 9. 13. The composition of claim 1, wherein the composition is capable of driving the ibuprofen and/or an ibuprofen salt through stratum corneum. 14. The composition of claim 1, wherein the stabilization polymer is present at at least about 0.5% by weight of the composition. 15. The composition of claim 1, wherein the propylene glycol is present at at least about 1% by weight of the composition. 16. The composition of claim 1, wherein the polysorbate surfactant is present at at least about 1% by weight of the composition. 17. The composition of claim 1, wherein the ibuprofen and/or the ibuprofen salt is present at at least about 0.1% by weight of the composition. 18. A method of topically treating or reducing inflammation or pain in a subject, comprising applying the composition of claim 1 to a site of inflammation or pain of the subject. 19. The method of claim 18, wherein the subject is a human.
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Radloff, Detlev; Wasner, Matthias, Active substance patch, kind to the skin, for transdermal administration of nonsteroidal antirheumatics.
Watanabe Kazuo (Shiga JPX) Tuchida Toshio (Shiga FL JPX) Schultz Duane R. (Miami FL), Anti-inflammatory and analgesic compounds, related compositions and methods for preparation and use thereof.
Saavedra Joseph E. (Thurmont MD) Keefer Larry K. (Bethesda MD) Roller Peter P. (Rockville MD) Akamatsu Miki (Rockville MD), Biopolymer-bound nitric oxide-releasing compositions, pharmaceutical compositions incorporating same and methods of trea.
Samour Carlos M. ; Krauser Scott F., Cationic film-forming polymer compositions, and use thereof in topical agents delivery system and method of delivering.
Samour Carlos M. ; Krauser Scott F., Cationic film-forming polymer compositions, and use thereof in topical agents delivery system and method of delivering.
Kenneth B Kirby ; Berno I. R. Pettersson, Jr., Compositions for rapid and non-irritating transdermal delivery of pharmaceutically active agents and methods for formulating such compositions and delivery thereof.
Kirby, Kenneth B; Pettersson, Berno, Compositions for rapid and non-irritating transdermal delivery of pharmaceutically active agents and methods for formulating such compositions and delivery thereof.
Kirby,Kenneth B; Pettersson,Berno, Compositions for rapid and non-irritating transdermal delivery of pharmaceutically active agents and methods for formulating such compositions and delivery thereof.
Carniglia Francis J. (Windsor Locks CT) Kenyon Alan J. (Hartford CT), Compositions of matter and methods for increasing intracellular ATP levels and physical performance levels and for incre.
Seguin, Marie-Christine, Cosmetic composition for slimming containing L-arginine, an L-arginine analogue, or one of their derivatives, for topical application.
Weuffen Wolfgang (Ringstrasse 39 D-17498 Guest DEX) Kramer Axel (Georg-Engel-Strasse 20 D-17489 Greifswald DEX) Tirsch Christel (Rudolf-Weiss-Strasse 36 D-99947 Bad Langensalza DEX) Meffert Hans (Ora, Cosmetic or pharmaceutic preparations for improving hair quaility and stimulating growth of the hair.
Gray Debora ; Schmelkin Nancy S. ; Alexander John ; Mark David A. ; Twyman Diana, Enternal formulation designed for optimized nutrient absorption and wound healing.
Sarpotdar Pramod P. (Audubon PA) Gaskill James L. (Devon PA) Giannini Robert P. (East Norriton PA) Daniels Charles R. (Erdenheim PA), L-a
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Samour Carlos ; Krauser Scott F., Lipophilic and amphiphilic or hydrophilic film-forming polymer compositions, and use thereof in topical agent delivery.
Katinger Hermann,ATX ; Vorauer-Uhl Karola,ATX ; Riedl Claus,ATX, Liposomal recombinant human superoxide-dismutase for the treatment of peyronie's disease.
Lang Gnther (Reinheim DEX) Wendel Harald (Ober-Ramstadt DEX), Macromolecular, surface-active, quaternary, N-substituted chitosan derivatives as well as cosmetic composition based on.
Garfield Robert E. (Friendswood TX) Balaban Alexandru T. (Galveston TX) Seitz William A. (Dickinson TX) Klein Douglas J. (Galveston TX) Lesko Melanie (Friendswood TX), N-nitroso-N-substituted hydroxylamines as nitric oxide donors.
Hrabie, Joseph A.; Keefer, Larry K., Nitric oxide-releasing amidine- and enamine-derived diazeniumdiolates, compositions and uses thereof and method of making same.
Tseng Susan Y. (Staten Island NY) Helioff Michael W. (Westfield NJ) Chuang Jui-Chang (Wayne NJ) Krummel H. Karl (Montville NJ) Davis Mary R. (Suffern NY), Non-irritating skin and hair rejuvenating compostion having a pH between 1 and 6.5.
Harrison Juan M. E. (Mountain View CA) Barclay Brian L. (Sunnyvale CA) Childers Jerry D. (Menlo Park CA) Wright Jeri D. (Dublin CA) Place Virgil A. (Kawaihae HI) Wong Patrick S. (Palo Alto CA), Oral osmotic device with hydrogel driving member.
Keefer Larry K. (Bethesda MD) Hrabie Joseph A. (Frederick MD), Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions and methods of treating biologic.
Smith Daniel J. (Stow OH) Chakravarthy Debashish (Garrettsville OH) Keefer Larry K. (Bethesda MD), Polysaccharide-bound nitric oxide-nucleophile adducts.
Venkateshwaran Srinivasan ; Fikstad David ; Ebert Charles D., Pressure sensitive adhesive matrix patches for transdermal delivery of salts of pharmaceutical agents.
Chaudhuri Ratan K. (Lincoln Park NJ) Biss Russell B. (Wayne NJ) Merianos John J. (Middletown NJ), Process for producing an alpha or beta-hydroxy acid-vinylpyrrolidone polymer, copolymer or graft polymer complex in the.
Eisenberg Solomon R. (Newton MA) Samour Carlos M. (Newport RI), Process for transport of agents across the skin and compositions and articles useful therein.
Daley Edwin W. (Cincinnati OH) Yowler M. Pauline (Springfield Township ; Hamilton County OH), Shampoo compositions which impart high luster and manageability to hair.
Kamishita Takuzo (Takatsuki JPX) Miyazaki Takashi (Nakaniikawa JPX) Okuno Yoshihide (Namerikawa JPX), Spray gel base and spray gel preparation using thereof.
Mentrup Edgar (Frankfurt DEX) Michel Christoph (Obertshausen DEX) Purmann Thomas (Aschaffenburg DEX), Stable small particle liposome preparations, their production and use in topical cosmetic, and pharmaceutical compositio.
Luo, Eric C.; Jacobson, Eric C.; Hsu, Tsung-Min, Topical and transdermal administration of peptidyl drugs with hydroxide-releasing agents as skin permeation enhancers.
Perricone Nicholas V. (27 Coginchaug Ct. Guilford CT 06437), Topical compositions and methods for treatment of skin damage and aging using catecholamines and related compounds.
Hechtman Herbert B. (Chestnut Hill MA), Topical formulations and methods for treating hemorrhoidal pain and sphincter and smooth muscle spasm in the gastrointes.
Hsu, Tsung-Min; Macy, Russell; Luo, Eric C., Transdermal administration of pharmacologically active amines using hydroxide-releasing agents as permeation enhancers.
Bello Gastone P. (Monmouth Beach NJ) Lyle John W. (Belmar NJ) Johnson Donald A. (Sea Girt NJ), Transdermal drug delivery device and method for its manufacture.
Garfield Robert E. ; Chwalisz Kristof,DEX, Treatment of urinary incontinence with nitric oxide synthase substrates and/or nitric oxide donors alone or in combinati.
Cooke John P. (Palo Alto CA) Dzau Victor J. (Los Altos Hills CA) Gibbons Gary H. (Palo Alto CA), Treatment of vascular degenerative diseases by modulation of endogenous nitric oxide production of activity.
Snyder Solomon H. (Baltimore MD) Burnett Arthur L. (Baltimore MD) Lowenstein Charles J. (Tacoma Park MD) Bredt David S. (Baltimore MD) Chang Thomas S. K. (Baltimore MD), Treatments for male sexual dysfunction.
Levere Richard D. (5 Seymour Pl. W. Armonk NY 10504) Abraham Nader G. (143 Charter Cir. Ossining NY 10562) Schwartzman Michel L. (415 Old Country Rd. Elmsford NY 10523) Martasek Pavel (60 Hillcrest R, Use of L-arginine in the treatment of hypertension and other vascular disorders.
Yoshimura Norman N. (Westminster CA) Barbul Adrian (Baltimore MD) Tao Robert C. (Huntington Beach CA) Storm Michael C. (Laguna Niguel CA) Kelley Robert E. (Orange CA) Reis Brenda L. (Costa Mesa CA), Use of arginine as an immunostimulator.
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