초록

This invention is directed to compound of Formula I and methods of using these compounds in the treatment of conditions in which modulation of a cathepsin, particularly cathepsin K or cathepsin L, will be therapeutically useful.

대표청구항 ▼

1. A compound of formula I: or a solvate or pharmaceutically acceptable salt thereof, wherein X is C(═O);n is 0 or 1;m is 0 or 1;p is 0 or 1;R1 and R2 are hydrogen;R3 and R5 are independently selected from the group consisting of hydroxyl, fluoro, and chloro; andR4 is selected from the group consis

1. A compound of formula I: or a solvate or pharmaceutically acceptable salt thereof, wherein X is C(═O);n is 0 or 1;m is 0 or 1;p is 0 or 1;R1 and R2 are hydrogen;R3 and R5 are independently selected from the group consisting of hydroxyl, fluoro, and chloro; andR4 is selected from the group consisting of hydroxyl, benzoyl, and halo. 2. The compound of claim 1, wherein the compound is 3-benzoyl benzophenone thiosemicarbazone (3) having the formula: 3. The compound of claim 1, wherein n=1, m=0, and p=1. 4. The compound of claim 3, wherein R3 and R5 are fluoro. 5. The compound of claim 4, wherein the compound is 1,3-bis-(4-fluorobenzoyl) benzene thiosemicarbazone (13) having the formula: 6. The compound of claim 1, wherein n=0, m=1, and p=0. 7. The compound of claim 6, wherein R4 is benzoyl. 8. The compound of claim 7, wherein the compound is 1,3,5-Tribenzoyl benzene thiosemicarbazone (25) having the formula: