[특허]Biomaterials for track and puncture closure

Biomaterials for track and puncture closure 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	A61B-017/03 A61B-017/00
출원번호	US-0773326 (2010-05-04)
등록번호	US-9463004 (2016-10-11)
발명자 / 주소	Campbell, Patrick Sawhney, Amarpreet S.
출원인 / 주소	Incept, LLC.
대리인 / 주소	Dardi & Herbert, PLLC
인용정보	피인용 횟수 : 0 인용 특허 : 177

초록

Embodiments include coatings for adherence of biomaterials to a tissue. Systems and methods for adapting such coated materials to vascular access closure are further proved.

대표청구항 ▼

1. An apparatus for treatment of a track and blood vessel large bore puncture comprising: an applicator, a plug comprising a proximal and a distal end preloaded in the applicator, and first and second reactive precursors preloaded in the applicator,with the applicator comprising a distal portion sized for placement in the track of the large bore puncture and having a distal opening and a lumen, and a pusher at least partially received in the lumen for pushing the plug out of the lumen through the distal opening,with the plug being sized for placement in the track of the large bore puncture and disposed within the lumen, andwith the precursors disposed in the lumen at a position distal to the distal end of the plug for release into the track of the large bore puncture prior to expulsion of the plug from the lumen,wherein the precursors are a powder in a dry state and react with physiological fluid after placement in the track to dissolve and form a matrix material that secures the plug within the puncture. 2. The apparatus of claim 1 wherein the first reactive precursor comprises electrophilic functional groups and the second reactive precursor comprises nucleophilic functional groups, wherein both of the precursors are polymers. 3. The apparatus of claim 1 wherein the plug comprises a rod, a tube, a rolled-up sheet, a twisted sheet, or a braided sheet. 4. The apparatus of claim 1 wherein the precursors dissolve in physiological fluid after placement in the track and undergo a covalent bonding reaction to form a matrix material that adheres to the plug and the track. 5. The apparatus of claim 1 comprising a plurality of the reactive precursors, wherein the precursors dissolve in physiological fluid after placement in the track and undergo a covalent bonding reaction to form a matrix material that adheres to the plug and the track. 6. The apparatus of claim 1 wherein the plug comprises a porous hydrogel. 7. The apparatus of claim 1 wherein the plug comprises a lyophilized hydrogel biomaterial. 8. The apparatus of claim 1 further comprising a buffer to increase a reaction rate of the precursors when exposed to fluid within the track. 9. The apparatus of claim 1 wherein the applicator comprises a sheath. 10. A method for treatment of a track and blood vessel puncture comprising: placing a distal portion of an applicator into the track, the applicator preloaded with a plug having proximal and distal ends and first and second reactive precursors distally beyond the distal end of the plug, wherein the precursors are a powder in a dry state and react with physiological fluid to dissolve the precursors;expelling the precursors from the applicator into at least a portion of the track, and subsequently expelling the distal end of the plug into the track, wherein the precursors react and form a matrix material adhesive to the track and the treatment substantially stops flow of blood into the track;wherein the puncture is a large bore puncture. 11. The method of claim 10 wherein the plug is expelled into the track and pushed through at least a portion of the track that received the precursors. 12. The method of claim 10 wherein the precursors are expelled into the track and a distal portion of the applicator is passed through at least a portion of the track that received the reactive precursors, and the plug is expelled into the track. 13. The method of claim 10 wherein the first precursor comprises electrophilic functional groups and the second precursor comprises nucleophilic functional groups, wherein both of the precursors are polymers. 14. The method of claim 10 wherein the plug comprises a rod, a tube, a rolled-up sheet, a twisted sheet, or a braided sheet. 15. The method of claim 10 wherein the precursors dissolve in physiological fluid after placement in the track and undergo a covalent bonding reaction to form a matrix material that secures the plug within the track. 16. The method of claim 10 comprising a plurality of the reactive precursors, wherein the precursors dissolve in physiological fluid after placement in the track and undergo a covalent bonding reaction to form a matrix material that adheres to the plug and the track. 17. The method of claim 10 comprising melting the precursors, with the melted precursor material being located distal to the plug in the applicator. 18. The method of claim 10 wherein the plug comprises a porous hydrogel. 19. The method of claim 10 wherein the plug comprises a lyophilized hydrogel biomaterial. 20. The method of claim 10 further comprising a buffer to increase a reaction rate of the precursors when exposed to fluid within the track. 21. The method of claim 10 wherein the applicator comprises a sheath. 22. The method of claim 21 further comprising passing the sheath over an introducer wire. 23. The method of claim 10, further comprising placing an elongate member including an expandable member into the track and expanding the expandable member within a body lumen adjacent the track, and wherein the precursors and plug are expelled from the applicator at a position around the elongate member and proximal the expanded expandable member. 24. The method of claim 23, further comprising removing the expandable member and applicator from the track through the plug. 25. A method for treatment of a track and blood vessel puncture, comprising: providing an applicator with a proximal end portion and a distal end portion preloaded with a plug having a proximal and a distal end and first and second reactive precursors distally beyond the distal end of the plug adjacent a distal end portion of the applicator, wherein the precursors are a powder in a dry state and react with physiological fluid to dissolve the precursors;positioning the distal end portion of the applicator near an arteriotomy in a distal portion of the track; andsequentially expelling the precursors and the plug from the distal end portion of the applicator into the track, wherein the precursors react and form a matrix material that secures the plug within the track relative to the arteriotomy,wherein the puncture is a large bore puncture. 26. The method of claim 25, wherein the plug is a lyophilized hydrogel biomaterial. 27. The method of claim 26, wherein the first precursor comprises electrophilic functional groups and the second precursor comprises nucleophilic functional groups, wherein both of the precursors are polymers. 28. The method of claim 25, further comprising introducing additional sealing material into all or a portion of the track.

이 특허에 인용된 특허 (177)

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상세보기
Muijs Van de Moer Wouter Matthijs,NLX ; Rienks Rienk,NLX, Occlusion assembly for sealing openings in blood vessels and a method for sealing openings in blood vessels.
상세보기
Dubrul, William Richard; Fulton, Richard E, Occlusion, anchoring, tensioning and flow direction apparatus and methods for use.
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Lombardi ; Jr. Edward J. (Malden MA) Neuman Harold L. (Reading MA) Magro Alfred E. (Woburn MA) Rishton Michael L. (Reading MA), Percutaneous intra-aortic balloon apparatus.
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Janzen Ernst (Laren NLX), Percutaneous introducer set and method for sealing puncture wounds.
상세보기
Cates, Christopher U.; Hornak, Robert C.; Stephens, Jr., Frank H., Percutaneous puncture sealing method.
상세보기
Buscemi Paul J. ; Bilge Fertac ; Holman Thomas J., Percutaneous repair of cardiovascular anomalies and repair compositions.
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Hubbell Jeffrey A. (Austin TX) Pathak Chandrashekhar P. (Waltham MA) Sawhney Amarpreet S. (Newton MA) Desai Neil P. (Los Angeles CA) Hill Jennifer L. (Austin TX), Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers.
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Kensey Kenneth (Chester Springs PA), Plug device for sealing openings and method of use.
상세보기
Kensey Kenneth (Chester Springs PA) Nash John (Downingtown PA), Plug devices for sealing punctures and methods of use.
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Harris J. Milton (Huntsville AL) Kozlowski Antoni (Huntsville AL), Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives t.
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Coury Arthur J. ; Avila Luis Z. ; Pathak Chandrashekhar P. ; Barman Shikha P., Poly(hydroxy acid)/polymer conjugates for skin applications.
상세보기
Kohn, Joachim; Kemnitzer, III, John E.; Poiani, George J.; Riley, David J., Polymer compositions comprising antifibrotic agents, and methods of treatment, pharmaceutical compositions, and methods of preparation therefor.
상세보기
Truter Patricia-Ann,ZAX ; Ntshudisane Sefora Francinah,ZAX ; Wilson Jessica Ruth,ZAX ; Cuthbert Gillian Rae,ZAX, Polyvinyl alcohol compositions prepared by crosslinking in a freezing step.
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Unger Peter D. (Convent Station NJ) Rohrbach Ronald P. (Flemington NJ), Process for making low density hydrogel materials having high surface areas.
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Nambu Masao (Yokohama JPX), Process for preparing a hydrogel.
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Rhee Woonza M. (Palo Alto CA) Berg Richard A. (Los Altos CA) Rosenblatt Joel S. (Palo Alto CA) Schroeder Jacqueline A. (Redwood City CA) Braga Larry J. (Fremont CA) Smestad Thomas L. (Palo Alto CA) F, Process for preparing a sterile, dry crosslinking agent.
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Wallajapet Palani Raj Ramaswami ; Qin Jian ; Williams Gary D., Process for preparing an absorbent foam.
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Funk Rudiger,DEX ; Herfert Norbert,DEX ; Riegel Ulrich,DEX, Process for the preparation of porous, hydrophilic, highly swellable hydrogels.
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Pathak, Chandrashekhar P.; Sawhney, Amarpreet S.; Dreher, James H., Protein crosslinkers, crosslinking methods and applications thereof.
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Wallace Donald G. ; Cruise Gregory M. ; Rhee Woonza M. ; Schroeder Jacqueline Anne ; Coker ; III George T. ; Maroney Marcee M., Rapid gelling biocompatible polymer composition.
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Kanesaka Nozomu (36 Cathy Rd. Hillsdale NJ 07642), Sealing device for a percutaneous puncture.
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Li Shu-Tung (1 Kiowa Ter. Oakland NJ 07436), Soft tissue closure systems.
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Shu-Tung Li, Soft tissue closure systems.
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Hammerslag Julius G., Surface opening adhesive sealer.
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Hammerslag Julius G. (San Juan Capistrano CA), Surface opening adhesive sealer.
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Barta Helmut (Vienna ATX) Eder Helmut (Vienna ATX) Granser Manfred (Vienna ATX) Habison Georg (Vienna ATX) Hantak Edith (Seebarn ATX) Moser Franz (Deutsch Wagram ATX) Pfaffenbichler Peter (Podersdorf, Syringe assembly for the storage and application of a biological multi-component material.
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Redmond, Russell J.; Vidal, Claude; Reich, Cary J.; Vega, Felix; Collinson, Michael; Rondinone, Joseph F., System and method for sealing vascular penetrations with hemostatic gels.
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Magro Alfred E. (Woburn MA) Rishton Michael (Reading MA), Tapered hemostatic device for use in conjunction with a catheter for alleviating blood leakage and method for using same.
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Shaw William J. (Cambridge MA), Treating wounds caused by medical procedures.
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Rudnick, James J., Vascular plug delivery system.
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Gershony Gary ; Kasprzyk Daniel J. ; Horzewski Michael J., Vascular sealing apparatus.
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Gershony Gary ; Kasprzyk Daniel J. ; Horzewski Michael J., Vascular sealing apparatus.
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Gershony Gary (44332 S. El Macero Dr. El Macero CA 95618) Kasprzyk Daniel J. (Fogelsville PA) Horzewski Michael J. (San Jose CA), Vascular sealing apparatus and method.
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Gershony Gary (1599 Swan Dr. Tulsa OK 74120) Nowakowski Karol W. (5476 Landmark Cir. Moundview MN 55112), Vascular sealing device.
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Edwards, Stuart D.; Lax, Ronald; Parker, Theodore L.; Wehman, Thomas C.; Kucklick, Theodore; Skalnyi, Eugene, Vascular sealing device with microwave antenna.
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Nash John (Downingtown PA) Evans Douglas (Devon PA) Fleischhacker John J. (Minnetonka MN), Vessel position locating device and method of use.
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Clark Jeffrey G. (Raleigh NC) Spranger Douglas M. (New York NY) Mulhauser Paul J. (New York NY) Lacotta Paul R. (Oradell NJ), Wound closure means and method using flowable adhesive.
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Weldon Thomas D. (Gainesville GA) Larsen Charles E. (Cumming GA) Rosen Jonathan J. (Alpharetta GA), Wound treating device and method for treating wounds.
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Weldon Thomas D. (Aguadilla PRX) Larsen Charles (Aguadilla PRX), Wound treating device and method of using same.
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IPC	Description
A	생활필수품
A62	인명구조; 소방(사다리 E06C)
A62B	인명구조용의 기구, 장치 또는 방법(특히 의료용에 사용되는 밸브 A61M 39/00; 특히 물에서 쓰이는 인명구조 장치 또는 방법 B63C 9/00; 잠수장비 B63C 11/00; 특히 항공기에 쓰는 것, 예. 낙하산, 투출좌석 B64D; 특히 광산에서 쓰이는 구조장치 E21F 11/00)
A62B-1/08	.. 윈치 또는 풀리에 제동기구가 있는 것

내보내기 구분	파일저장 인쇄 메일전송
구성항목	기본정보 상세정보 관리번호, 국가코드, 자료구분, 상태, 출원번호, 출원일자, 공개번호, 공개일자, 등록번호, 등록일자, 발명명칭(한글), 발명명칭(영문), 출원인(한글), 출원인(영문), 출원인코드, 대표IPC 관리번호, 국가코드, 자료구분, 상태, 출원번호, 출원일자, 공개번호, 공개일자, 공고번호, 공고일자, 등록번호, 등록일자, 발명명칭(한글), 발명명칭(영문), 출원인(한글), 출원인(영문), 출원인코드, 대표출원인, 출원인국적, 출원인주소, 발명자, 발명자E, 발명자코드, 발명자주소, 발명자 우편번호, 발명자국적, 대표IPC, IPC코드, 요약, 미국특허분류, 대리인주소, 대리인코드, 대리인(한글), 대리인(영문), 국제공개일자, 국제공개번호, 국제출원일자, 국제출원번호, 우선권, 우선권주장일, 우선권국가, 우선권출원번호, 원출원일자, 원출원번호, 지정국, Citing Patents, Cited Patents
저장형식	Text(ASCII format) Excel format PIAS분석(.xls)
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

연합인증

Biomaterials for track and puncture closure 원문보기

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Biomaterials for track and puncture closure 원문보기

초록

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