[특허]Treatment for dopaminergic disorders

Treatment for dopaminergic disorders 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	A61K-031/4439 A61K-031/135
출원번호	US-0253528 (2014-04-15)
등록번호	US-9463186 (2016-10-11)
발명자 / 주소	Surmeier, Dalton J. Sanchez, Javier Guzman, Jaime Zampese, Enrico Galtieri, Daniel Ilijic, Ema
출원인 / 주소	Northwestern University
대리인 / 주소	Casimir Jones, S.C.
인용정보	피인용 횟수 : 0 인용 특허 : 46

초록 ▼

The present invention provides systems, compositions and methods for treatment of dopaminergic disorders (e.g., Parkinson's disease) using the combination of a first compound that inhibits a voltage-gated calcium channel of the type Cav1.3 (e.g., a dihydropyridine such as isradipine), and a second compound that is monoamine oxidase inhibitor and/or is a nitric oxide synthase inhibitor (e.g., rasagiline or derivative thereof).

대표청구항 ▼

1. A method of treatment for Parkinson's disease comprising: administering to a human subject having Parkinson's disease i) a first compound that comprises isradipine, andii) a second compound that comprises rasagiline,wherein said administering provides at least 0.5 mg, and no more than 5 mg, of said isradipine per day, andwherein said administering is repeated for multiple days. 2. The method of claim 1, wherein said administering provides about 0.5 to about 2 mg of said rasagiline per day to said subject. 3. The method of claim 1, wherein said administering provides about 2 mg of said rasagiline per day to said subject. 4. The method of claim 1, wherein said administering provides no more than 3 mg of said isradipine per day. 5. The method of claim 1, wherein said first compound is in a controlled release formulation. 6. A composition comprising: i) a first compound that comprises isradipine, wherein said isradipine is present in said first composition between 0.5 mg and 5 mg, andii) a second compound that comprises rasagiline. 7. The composition of claim 6, wherein said rasagiline is present in said second composition between about 0.5 to about 2 mg. 8. The composition of claim 6, wherein said rasagiline is present in said second composition at about 2 mg. 9. The composition of claim 6, wherein said first composition contains no more than 3 mg of said isradipine. 10. The composition of claim 6, wherein said first compound is in a controlled release formulation within said composition. 11. A kit comprising: i) a first composition comprising a first compound that comprises isradipine, wherein said isradipine is present in said first composition between 0.5 mg and 5 mg, andii) a second composition comprising a second compound that comprises rasagiline. 12. The kit of claim 11, wherein said rasagiline is present in said second composition between about 0.5 to about 2 mg. 13. The kit of claim 11, wherein said rasagiline is present in said second composition at about 2 mg. 14. The kit of claim 11, wherein said first composition contains no more than 3 mg of said isradipine.

이 특허에 인용된 특허 (46)

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