초록 ▼

The present disclosure relates to methods of reducing the onset of allergies. In certain embodiments, the method includes administering to an infant a nutritional composition that includes a fat or lipid source, a carbohydrate source, a protein source comprising whey and casein proteins and, optiona

The present disclosure relates to methods of reducing the onset of allergies. In certain embodiments, the method includes administering to an infant a nutritional composition that includes a fat or lipid source, a carbohydrate source, a protein source comprising whey and casein proteins and, optionally, a probiotic. In certain embodiments, the whey:casein ratio in the protein source is from about 50:50 to about 70:30 and the degree of hydrolysis of the proteins included in the protein source is from about 4% to about 10%.

대표청구항 ▼

1. A method of increasing the concentration of fecal secretory IgA in a child having an allergic reaction to at least one antigen, wherein the child is at least two years of age or older, the method comprising the steps of: exposing the child, when the child is an infant, to the at least one antigen

1. A method of increasing the concentration of fecal secretory IgA in a child having an allergic reaction to at least one antigen, wherein the child is at least two years of age or older, the method comprising the steps of: exposing the child, when the child is an infant, to the at least one antigen, wherein the at least one antigen is selected from the group consisting of cow's milk, egg, soy, house dust, and mites; andadministering to the child, when the child is an infant, a nutritional composition comprising from 3 g/100 kcal to 7 g/100 kcal of a fat or lipid source; from 8 g/100 kcal to 12 g/100 kcal of a carbohydrate source, wherein the carbohydrate source comprises between 15% and 55% lactose by weight; a probiotic source comprising Lactobacillus rhamnosus GG; a non-human lactoferrin; a prebiotic source comprising galactooligosaccharide and polydextrose, wherein the prebiotic source is present in the nutritional composition in an amount of from 0.1 g/100 kcal to 1 g/100 kcal; and a protein source comprising whey and casein proteins, wherein the protein source is present in the nutritional composition in an amount of from 1 g/100 kcal to 5 g/100 kcal, further wherein the ratio of whey to casein proteins in the protein source is from 50:50 to 70:30 by weight and wherein the degree of hydrolysis of the whey and casein proteins included in the protein source is from 4% to 10%. 2. The method according to claim 1, wherein the probiotic source further comprises a probiotic selected from the group consisting of Lactobacillus species, Bifidobacterium species, Bifidobacterium longum, Bifidobacterium animalis subsp. lactis BB-12, and combinations thereof. 3. The method according to claim 1, wherein the child has a family history of allergies. 4. The method according to claim 1, wherein the degree of hydrolysis of the whey and casein proteins included in the protein source is from 6% to 9%. 5. The method according to claim 1, wherein the whey and casein proteins in the protein source have the following molecular weight distribution: Molar Mass% Molecular Weight(in Daltons)Distribution 5000 2-11. 6. The method according to claim 1, wherein the whey and casein proteins in the protein source have the following molecular weight distribution: Molar Mass% Molecular Weight(in Daltons)Distribution 5000 2.8. 7. The method of claim 1, wherein the nutritional composition further comprises TGF-β. 8. The method of claim 1, wherein the child was born as a preterm infant. 9. The method of claim 1, wherein the nutritional composition is an infant formula. 10. The method of claim 1, wherein the child has a family history of allergies. 11. A method of inducing oral tolerance in a child having an allergic reaction to at least one antigen, wherein the child is at least two years of age or older, the method comprising the steps of: exposing the child, when the child is an infant, to the at least one antigen, wherein the at least one antigen is selected from the group consisting of cow's milk, egg, soy, house dust, and mites; andadministering to the child, when the child is an infant, a nutritional composition comprisingfrom 3 g/100 kcal to 7 g/100 kcal of a fat or lipid source;from 8 g/100 kcal to 12 g/100 kcal of a carbohydrate source, wherein the carbohydrate source comprises between 15% and 55% lactose by weight;a probiotic source comprising Lactobacillus rhamnosus GG;a non-human lactoferrin;a prebiotic source comprising galactooligosaccharide and polydextrose, wherein the prebiotic source is present in the nutritional composition in an amount of from 0.1 g/100 kcal to 1 g/100 kcal; and aprotein source comprising whey and casein proteins, wherein the protein source is present in the nutritional composition in an amount of from 1 g/100 kcal to 5 g/100 kcal, further wherein the ratio of whey to casein proteins in the protein source is from 50:50 to 70:30 by weight and wherein the degree of hydrolysis of the whey and casein proteins included in the protein source is from 4% to 10%. 12. The method according to claim 11, wherein the probiotic source further comprises a probiotic selected from the group consisting of Lactobacillus species, Bifidobacterium species, Bifidobacterium longum, Bifidobacterium animalis subsp. lactis BB-12, and combinations thereof. 13. The method according to claim 11, wherein the child has a family history of allergies. 14. The method according to claim 11, wherein the degree of hydrolysis of the whey and casein proteins included in the protein source is from 6% to 9%. 15. The method according to claim 11, wherein the whey and casein proteins in the protein source have the following molecular weight distribution: Molar Mass % Molecular Weight(in Daltons)Distribution 5000  2-11. 16. The method according to claim 11, wherein the whey and casein proteins in the protein source have the following molecular weight distribution: Molar Mass% Molecular Weight(in Daltons)Distribution 50002.8. 17. The method of claim 11, wherein the nutritional composition further comprises TGF-β. 18. The method of claim 11, wherein the child was born as a preterm infant. 19. The method of claim 11, wherein the nutritional composition is an infant formula. 20. A method of inducing oral tolerance in a child having an allergy to at least one antigen, wherein the child is at least two years of age or older, the method comprising the steps of: exposing the child, when the child is an infant, to the at least one antigen, wherein the at least one antigen is selected from the group consisting of cow's milk, egg, soy, house dust, and mites; andadministering to the child, when the child is an infant, a nutritional composition comprising from 3 g/100 kcal to 7 g/100 kcal of a fat or lipid source;from 8 g/100 kcal to 12 g/100 kcal of a carbohydrate source, wherein the carbohydrate source comprises between 15% and 55% lactose by weight;a probiotic source comprising Lactobacillus rhamnosus GG;lactoferrin from a non-human source;a prebiotic source comprising galactooligosaccharide and polydextrose, wherein the prebiotic source is present in the nutritional composition in an amount of from 0.1 g/100 kcal to 1 g/100 kcal; and aprotein source comprising whey and casein proteins, wherein the protein source is present in the nutritional composition in an amount of from 1 g/100 kcal to 5 g/100 kcal, further wherein the ratio of whey to casein proteins in the protein source is from 50:50 to 70:30 by weight and wherein the degree of hydrolysis of the whey and casein proteins included in the protein source is from 4% to 10%; andsubsequently exposing the child to the at least one antigen.