[특허]Mineralization and biological modification of biomaterial surfaces

Mineralization and biological modification of biomaterial surfaces 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	A61L-027/00 A61L-027/18 A61L-027/50 A61L-027/44 A61L-027/56 A61L-027/58
출원번호	US-0724206 (2015-05-28)
등록번호	US-9480773 (2016-11-01)
발명자 / 주소	Murphy, William L. Peters, Martin C. Mooney, David J.
출원인 / 주소	THE REGENTS OF THE UNIVERSITY OF MICHIGAN
대리인 / 주소	Marshall, Gerstein & Borun LLP
인용정보	피인용 횟수 : 0 인용 특허 : 41

초록 ▼

Disclosed are advantageous methods for patterning and/or mineralizing biomaterial surfaces. The techniques described are particularly useful for generating three-dimensional or contoured bioimplant materials with patterned surfaces or patterned, mineralized surfaces. Also provided are various methods of using the mineralized and/or patterned biomaterials in tissue engineering, such as bone tissue engineering, providing more control over ongoing biological processes, such as mineralization, growth factor release, cellular attachment and tissue growth.

대표청구항 ▼

1. A method for controlling mineralization of a biomaterial surface, comprising: (a) functionalizing at least a first surface of a biomaterial; and(b) contacting the functionalized biomaterial surface with an amount of a mineral-containing solution effective to form a mineralized biomaterial,wherein (i) the mineralized biomaterial comprises an extended, mineral coating at the functionalized biomaterial surface and is degradable over a controllable time scale; and(ii) the biomaterial comprises at least a first porous, biodegradable polymer portion having an interconnected pore structure and further comprises at least a first portion that is prepared by a process comprising heating a biodegradable polymer. 2. The method of claim 1 wherein heating the biodegradable polymer in a heat pressing process. 3. The method of claim 1 wherein the polymer portion of the biomaterial is a poly(alpha-hydroxy acid). 4. The method of claim 1 wherein the functionalizing of at least a first surface of a biomaterial creates a plurality of polar oxygen groups on the biomaterial surface. 5. The method of claim 1 wherein said mineral coating is osteoconductive. 6. The method of claim 1 wherein the biomaterial is associated with a biologically effective amount of at least a first bioactive substance or biological cell. 7. A method for controlling mineralization of a biomaterial surface, said method comprising: (a) forming a biomaterial by heating a biodegradable polymer, said biomaterial comprising at least a first porous, biodegradable polymer portion that has an interconnected pore structure;(b) functionalizing a first surface of said biomaterial; and(c) contacting the functionalized biomaterial surface with an amount of a mineral-containing solution effective to form a mineralized biomaterial that comprises an extended, mineral coating at the functionalized biomaterial surface. 8. The method of claim 7 wherein the forming a biomaterial by heating a biodegradable polymer comprises heat pressing. 9. The method of claim 7 wherein said biodegradable polymer is a poly(alpha-hydroxy) acid. 10. The method of claim 7 wherein the functionalizing a first surface of said biomaterial creates a plurality of polar oxygen groups on the biomaterial surface. 11. The method of claim 7 wherein said mineral coating is osteoconductive. 12. The method of claim 7 wherein the biomaterial is associated with a biologically effective amount of at least a first bioactive substance or biological cell. 13. A method for generating an extended, osteoconductive mineral coating on a surface of a porous, biodegradable polymer biomaterial, comprising: contacting a surface of said porous, biodegradable polymer biomaterial with an amount of a mineral-containing solution effective to form an extended, osteoconductive mineral coating on said surface, wherein said porous, biodegradable polymer biomaterial has an interconnected pore structure and is degradable over a controllable time scale; andsaid biomaterial comprises at least a first portion that is prepared by a process comprising heating a biodegradable polymer. 14. The method of claim 13 wherein heating is heat pressing. 15. The method of claim 13 wherein the biodegradable polymer is poly(alpha-hydroxy acid). 16. The method of claim 13 further comprising exposing at least a first surface of said biomaterial to a functionalizing pre-treatment to create a functionalized biomaterial surface prior to contacting the biomaterial surface with an amount of a mineral-containing solution. 17. The method of claim 16, wherein the functionalized biomaterial surface is contacted with said mineral-containing solution for a time effective to form discrete mineral islands that expand to form a substantially homogeneous, osteoconductive mineral coating. 18. The method of claim 13 wherein the biomaterial surface is part of a 3-dimensional biomaterial scaffold. 19. The method of claim 13 wherein the biomaterial is associated with a biologically effective amount of at least a first bioactive substance or biological cell. 20. The method of claim 16 wherein said biodegradable polymer biomaterial is a poly(alpha-hydroxy) acid.

이 특허에 인용된 특허 (41)

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Boyce Todd M. ; Shimp Lawrence A. ; Manrique Albert, Load-bearing osteoimplant, method for its manufacture and method of repairing bone using same.
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IPC	Description
A	생활필수품
A62	인명구조; 소방(사다리 E06C)
A62B	인명구조용의 기구, 장치 또는 방법(특히 의료용에 사용되는 밸브 A61M 39/00; 특히 물에서 쓰이는 인명구조 장치 또는 방법 B63C 9/00; 잠수장비 B63C 11/00; 특히 항공기에 쓰는 것, 예. 낙하산, 투출좌석 B64D; 특히 광산에서 쓰이는 구조장치 E21F 11/00)
A62B-1/08	.. 윈치 또는 풀리에 제동기구가 있는 것

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연합인증

Mineralization and biological modification of biomaterial surfaces 원문보기

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Mineralization and biological modification of biomaterial surfaces 원문보기

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