$\require{mediawiki-texvc}$

연합인증

연합인증 가입 기관의 연구자들은 소속기관의 인증정보(ID와 암호)를 이용해 다른 대학, 연구기관, 서비스 공급자의 다양한 온라인 자원과 연구 데이터를 이용할 수 있습니다.

이는 여행자가 자국에서 발행 받은 여권으로 세계 각국을 자유롭게 여행할 수 있는 것과 같습니다.

연합인증으로 이용이 가능한 서비스는 NTIS, DataON, Edison, Kafe, Webinar 등이 있습니다.

한번의 인증절차만으로 연합인증 가입 서비스에 추가 로그인 없이 이용이 가능합니다.

다만, 연합인증을 위해서는 최초 1회만 인증 절차가 필요합니다. (회원이 아닐 경우 회원 가입이 필요합니다.)

연합인증 절차는 다음과 같습니다.

최초이용시에는
ScienceON에 로그인 → 연합인증 서비스 접속 → 로그인 (본인 확인 또는 회원가입) → 서비스 이용

그 이후에는
ScienceON 로그인 → 연합인증 서비스 접속 → 서비스 이용

연합인증을 활용하시면 KISTI가 제공하는 다양한 서비스를 편리하게 이용하실 수 있습니다.

Ultra-sensitive detection of molecules or particles using beads or other capture objects

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • G01N-033/543
출원번호 US-0530979 (2012-06-22)
등록번호 US-9482662 (2016-11-01)
발명자 / 주소
  • Duffy, David C.
  • Rissin, David M.
  • Walt, David R.
  • Fournier, David
  • Kan, Cheuk
출원인 / 주소
  • Quanterix Corporation
대리인 / 주소
    Wolf, Greenfield & Sacks, P.C.
인용정보 피인용 횟수 : 5  인용 특허 : 105

초록

The present invention relates to systems and methods for detecting analyte molecules or particles in a fluid sample and in some cases, determining a measure of the concentration of the molecules or particles in the fluid sample. Methods of the present invention may comprise immobilizing a plurality

대표청구항

1. A method for determining a measure of the concentration of a plurality of types of analyte molecules or particles, said plurality including at least a first type of analyte molecules or particles and a second type of analyte molecules or particles in a fluid sample, comprising: providing a substr

이 특허에 인용된 특허 (105)

  1. Gelfand, David Harrow; Reichert, Fred Lawrence; Bodepudi, Veeraiah; Gupta, Amar; Will, Stephen; Myers, Thomas, 2'-terminator nucleotide-related methods and systems.
  2. Boisde Gilbert (Bures Sur Yvette FRX) Perez Jean-Jacques (Chattillon FRX), Active chemical transducer with optical fibres and reagent supporting means.
  3. Ivarsson, Bengt, Analytical method and apparatus.
  4. Southern Edwin (Oxford GB2), Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays.
  5. Allen Fritz S. (Corrales NM) Bustamante Carlos (Albuquerque NM) Niemczyk Thomas M. (Albuquerque NM) Dorman Burton P. (Berkeley CA), Area-modulated luminescence (AML).
  6. Dickinson, Todd A.; Meade, Shawn; Barnard, Steven M.; Czarnik, Anthony W.; Bierle, James; Kermani, Bahram G.; Chee, Mark S., Array compositions for improved signal detection.
  7. Seul,Michael; Li,Alice Xiang, Array cytometry.
  8. Fodor Stephen P. A. (Palo Alto CA) Pirrung Michael C. (Durham NC) Read J. Leighton (Palo Alto CA) Stryer Lubert (Stanford CA), Array of oligonucleotides on a solid substrate.
  9. Babson Arthur L. ; Palmieri Thomas ; Montalbano Anthony P. ; Montalbano Chris P. ; Montalbano Greg A. ; Fleischer Eric C., Automated immunoassay analyzer.
  10. Nova Michael P. ; Lillig John E. ; Karunaratne Kanchana Sanjaya Gunesekera ; Ewing William ; Satoda Yozo ; Potash Hanan, Automated sorting system for matrices with memory.
  11. Lough David M.,DEX ; Koster Hubert, Bead linkers for immobilizing nucleic acids to solid supports.
  12. Koster Hubert ; Lough David M.,GBX, Beads bound to a solid support and to nucleic acids.
  13. David R. Walt ; Laura C. Taylor, Biosensor array comprising cell populations confined to microcavities.
  14. Fujimoto Edward K. (Rockford IL), Biotin containing heterobifunctional cleavable compounds.
  15. Bouanani, Majida; Kamal, Nadia; Larue, Catherine Christianne Marie; Pau, Bernard Christian; Siohan, Elisabeth, C-peptide specific assay procedure.
  16. Bobrow Mark Norman ; Litt Gerald Joseph, Catalyzed reporter deposition.
  17. Kameda Naomi (Woodside CA) Rowley Gerald L. (San Jose CA), Cleavable labels for use in binding assays.
  18. Chee, Mark; Walt, David R., Combinatorial decoding of random nucleic acid arrays.
  19. Winkler, James L.; Fodor, Stephen P. A.; Buchko, Christopher J.; Ross, Debra A.; Aldwin, Lois; Modlin, Douglas N., Combinatorial strategies for polymer synthesis.
  20. Chee, Mark S.; Auger, Steven R.; Stuelpnagel, John R., Composite arrays utilizing microspheres.
  21. Walt,David R.; Schauer,Caroline L.; Steemers,Frank J., Cross-reactive sensors.
  22. McDevitt, John T.; Anslyn, Eric V.; Shear, Jason B.; Neikirk, Dean P., Detection system based on an analyte reactive particle.
  23. Buechler Kenneth Francis, Diagnostic devices and apparatus for the controlled movement of reagents without membranes.
  24. Robinson David (Folkestone GB2) Bate Ernest (Great Chart GB2) Kellard Simon (Ashford GB2) Watson Mark (Ashford MA GB2) Mahan Donald E. (Grafton MA) Shimei Thomas M. (Franklin MA) Kearney Kevin R. (Wo, Diagnostics instrument.
  25. Allen Fritz (Corrales NM) Niemczyk Thomas (Albuquerque NM), Digital analyte detection system.
  26. Allen Fritz (Corrales NM) Niemczyk Thomas (Albuquerque NM), Digital analyte detection system.
  27. Walt,David R.; Szunerits,Sabine, Electro-optical stimulation/measurement.
  28. Hammock Bruce D. ; Moghaddam Mehran F. ; Cheek Jeffrey M. ; Borhan Babak ; Fergusson James ; Grant David F. ; Greene Jessica F. ; Matoba Kazuhiko,JPX ; Zheng Jiang ; Sisemore Marlene F., Epoxide hydrolase inhibitor methods.
  29. Zhong William J. S. (Stamford CT) Williams John A. (Monroe CT), Etchable core glass compositions and method for manufacturing a high performance microchannel plate.
  30. Walt, David R.; Barnard, Steven M., Fiber optic array sensors, apparatus, and methods for concurrently visualizing and chemically detecting multiple analytes of interest in a fluid sample.
  31. David R. Walt ; Brian G. Healey, Fiber optic biosensor for selectively detecting oligonucleotide species in a mixed fluid sample.
  32. David R. Walt ; Brian G. Healey, Fiber optic biosensor for selectively detecting oligonucleotide species in a mixed fluid sample.
  33. Peterson John I. (Falls Church VA) Goldstein Seth R. (Bethesda MD), Fiber optic pH probe.
  34. Walt David R. ; Tabacco Mary Beth ; Uttamlal Mahesh,GBX, Fiber optic sensor for long-term analyte measurements in fluids.
  35. Walt David R. ; Michael Karri Lynn, Fiber optic sensor with encoded microspheres.
  36. Walt David R. ; Michael Karri Lynn, Fiber optic sensor with encoded microspheres.
  37. Walt David R. (Lexington MA) Bernard Steven M. (Basel CHX), Fiber optic sensor, apparatus, and methods for detecting an organic analyte in a fluid or vapor sample.
  38. Wlodarczyk Marek T. (Birmingham MI) Coletta Luciano (Ypsilanti MI) Campbell James A. (Ann Arbor MI) Tomasko Douglas G. (Ypsilanti MI), Fiber optic sensors.
  39. Walt David R. (Lexington MA), Fiber optic sensors, apparatus, and detection methods using controlled release polymers and reagent formulations held wi.
  40. Pinkel Daniel (Walnut Creek CA) Gray Joe (San Francisco CA), High density array fabrication and readout method for a fiber optic biosensor.
  41. Walt,David R., High density optical data storage.
  42. Goix, Philippe J.; Puskas, Robert; Todd, John; Livingston, Richard A.; Held, Douglas; Wu, Alan, Highly sensitive system and methods for analysis of troponin.
  43. Walt David R. (Lexington MA) Barnard Steven M. (Medford MA), Imaging fiber optic array sensors, apparatus, and methods for concurrently detecting multiple analytes of interest in a.
  44. Nelson Robert J. ; Hooper Herbert H. ; Hauser Alan K. ; Sassi Alexander P., Integrated microfluidic devices.
  45. Marquiss, Samuel A.; Cesar, Christopher G.; Petersen, Jon F.; Stumbo, David P.; El-Hage, Amer; Edwards, Glenn R.; Modlin, Douglas N.; Leytes, Ley J.; Burd, Samuel, Integrated sample-processing system.
  46. Pirrung Michael C. (Durham NC) Read J. Leighton (Palo Alto CA) Fodor Stephen P. A. (Palo Alto CA) Stryer Lubert (Stanford CA), Large scale photolithographic solid phase synthesis of an array of polymers.
  47. Albrecht Glenn ; Brenner Sydney,GBX ; DuBridge Robert B. ; Lloyd David H. ; Pallas Michael C., Massively parallel signature sequencing by ligation of encoded adaptors.
  48. Houghten Richard A. (Solana Beach CA), Means for sequential solid phase organic synthesis and methods using the same.
  49. Bisconte Jean-Claude (Vaucresson FRX), Means to automatically hold, process, store and analyze biological samples.
  50. John R. Stuelpnagel ; Mark S. Chee ; Richard J. Pytelewski ; Todd Alan Dickinson ; Gan G. Wang, Method and apparatus for retaining and presenting at least one microsphere array to solutions and/or to optical imaging systems.
  51. Singh Sharat (San Jose CA) Switchenko Arthur C. (Palo Alto CA) Lin Cheng-I (Cupertino CA) Kurn Nurith (Palo Alto CA) Ullman Edwin F. (Atherton CA), Method and kits for determining peroxidatively active catalysts.
  52. Bobrow Mark N. (Woburn MA) Litt Gerald J. (Wellesley MA), Method for detection or quantitation of an analyte using an analyte dependent enzyme activation system.
  53. Jett James H. (Los Alamos NM) Keller Richard A. (Los Alamos NM) Martin John C. (Los Alamos NM) Moyzis Robert K. (Los Alamos NM) Ratliff Robert L. (Los Alamos NM) Shera E. Brooks (Los Alamos NM) Stewa, Method for rapid base sequencing in DNA and RNA.
  54. Bobrow Mark N. (Woburn MA) Litt Gerald J. (Wellesley MA), Method for the detection or quantitation of an analyte using an analyte dependent enzyme activation system.
  55. Berkey George E. (Pine City NY), Method of enlarging end of capillary tube bore.
  56. Chee,Mark S.; Stuelpnagel,John R.; Czarnik,Anthony W., Method of making and decoding of array sensors with microspheres.
  57. Walt David R. (Lexington MA) Barnard Steven M. (Medford MA), Method of making imaging fiber optic sensors to concurrently detect multiple analytes of interest in a fluid sample.
  58. Brown James F. ; Silver Jonathan E. ; Kalinina Olga V.,CAX, Method of sampling, amplifying and quantifying segment of nucleic acid, polymerase chain reaction assembly having nanoliter-sized sample chambers, and method of filling assembly.
  59. Rothberg,Jonathan M.; Bader,Joel S.; Dewell,Scott B.; McDade,Keith; Simpson,John W.; Berka,Jan; Colangelo,Christopher M., Method of sequencing a nucleic acid.
  60. Rothberg,Jonathan M.; Bader,Joel S.; Dewell,Scott B.; McDade,Keith; Simpson,John W.; Berka,Jan; Colangelo,Christopher M., Method of sequencing a nucleic acid.
  61. Rothberg,Jonathan M.; Bader,Joel S.; Dewell,Scott B.; McDade,Keith; Simpson,John W.; Berka,Jan; Colangelo,Christopher M., Method of sequencing a nucleic acid.
  62. Peter Eriksson SE; Owe Orwar SE; Daniel T. Chiu, Method, apparatus and flow cell for high-sensitivity detection of fluorescent molecules.
  63. Cargill John ; Armstrong Robert W., Methods and apparatus for synthesizing labeled combinatorial chemistrylibraries.
  64. Walt, David R.; Rissin, David M., Methods and arrays for detecting cells and cellular components in small defined volumes.
  65. Walt, David R.; Rissin, David M.; Gorris, Hans-Heiner, Methods and arrays for target analyte detection and determination of reaction components that affect a reaction.
  66. Walt, David R.; Rissin, David M., Methods and arrays for target analyte detection and determination of target analyte concentration in solution.
  67. Rissin, David M.; Fournier, David; Duffy, David C., Methods and systems for extending dynamic range in assays for the detection of molecules or particles.
  68. Rissin, David M.; Fournier, David; Duffy, David C., Methods and systems for extending dynamic range in assays for the detection of molecules or particles.
  69. Brown Patrick O. ; Shalon Tidhar Dari, Methods for fabricating microarrays of biological samples.
  70. Mark A. Gallop ; Eric Gordon ; Zhi-Jie Ni ; Derek MacLean ; Christopher Holmes ; William Fitch ; Nikhil Shah, Methods for hard-tagging an encoded synthetic library.
  71. Rava Richard P. (San Jose CA) Fodor Stephen P. A. (Palo Alto CA) Trulson Mark (San Jose CA), Methods for making a device for concurrently processing multiple biological chip assays.
  72. Gert Blankenstein DE, Micro-flow system for particle separation and analysis.
  73. Anderson, Norman G.; Anderson, N. Leigh, Microarrays and their manufacture.
  74. Bamdad Cynthia C. (Sharon MA) Sigal George B. (Arlington MA) Strominger Jack L. (Lexington MA) Whitesides George M. (Newton MA), Molecular recognition at surfaces derivatized with self-assembled monolayers.
  75. Ichikawa Takanori (Takasaki JPX) Kuwaki Tomoaki (Maebashi JPX) Matsuki Shigeru (Takasaki JPX) Tachibana Katsumi (Maebashi JPX), Monoclonal antibodies and method for the determination of human G-CSF.
  76. Chandler Van S. ; Fulton R. Jerrold ; Chandler Mark B., Multiplexed analysis of clinical specimens apparatus and methods.
  77. Fodor, Stephen P.A.; Solas, Dennis W.; Dower, William J.; Huang, Xiaohua C., Oligonucleotides.
  78. Walt,David R.; Weissman,Irving L.; Biran,Israel; Tam,Jenny, Optical array device and methods of use thereof for screening, analysis and manipulation of particles.
  79. Walt David R. ; Taylor Laura, Optical fiber biosensor array comprising cell populations confined to microcavities.
  80. Walt, David R.; Taylor, Laura, Optical fiber biosensor array comprising cell populations confined to microcavities.
  81. Allen Fritz S. (Corrales) Bustamante Carlos (Albuquerque) Niemczyk Thomas M. (Albuquerque NM) Dorman Burton P. (Berkeley CA), Optical method for measuring an analyte using area-modulated luminescence.
  82. Walt David R. ; Michael Karri L ; Chadha Suneet, Optical sensor apparatus for far-field viewing and making optical analytical measurements at remote locations.
  83. Walt David R. (Lexington MA) Kauer John S. (Weston MA), Optical sensor, optical sensing apparatus, and methods for detecting an analyte of interest using spectral recognition p.
  84. Song, Xuedong; Wei, Ning; Sayre, Curt, Polyelectrolytic internal calibration system of a flow-through assay.
  85. Hurni William M. (North Wales PA) Miller William J. (North Wales PA), Radio-immuno assay for hepatitis B virus PreS2 antibodies.
  86. Carlsson Jan P. E. (Upsala SEX) Axen Rolf E. A. V. (Blinge SEX) Drevin Hakan N. Y. (Brunna SEX), Reagent for use in immunochemical assay methods.
  87. Monforte, Joseph A.; Becker, Christopher H.; Pollart, Daniel J.; Shaler, Thomas A., Releasable nonvolatile mass label molecules.
  88. Love, J. Christopher; Ploegh, Hidde L.; Ronan, Jehnna, Screening assays and methods.
  89. Walt,David R.; Dickinson,Todd A., Self-encoding fiber optic sensor.
  90. Walt,David R.; Dickinson,Todd A., Self-encoding sensor with microspheres.
  91. Allen Fritz S. (Corrales NM), Sensitive light detection system.
  92. Bergeron Michel G.,CAX ; Ouellette Marc,CAX ; Roy Paul H.,CAX, Species specific and universal DNA probes and amplification primers to rapidly detect and identify common bacterial pathogens and associated antibiotic resistance genes from clinical specimens for ro.
  93. Walt David R. (Lexington MA) Pantano Paul (Everett MA), Superresolution imaging fiber for subwavelength light energy generation and near-field optical microscopy.
  94. Allawi, Hatim Taysir; Elagin, Vecheslav A.; Lyamichev, Victor A.; Wu, Kwok; Iszczyszyn, Walter; Fleming, Chris; Chehak, LuAnne; Law, Scott M., T-structure invasive cleavage assays, consistent nucleic acid dispensing, and low level target nucleic acid detection.
  95. Walt David R. ; Michael Karri L., Target analyte sensors utilizing Microspheres.
  96. Walt, David R.; Michael, Karri L., Target analyte sensors utilizing microspheres.
  97. Walt David R. (Lexington MA) Bronk Karen S. (Somerville MA), Thin film fiber optic sensor array and apparatus for concurrent viewing and chemical sensing of a sample.
  98. Buechler Kenneth F. (Santee CA) Valkirs Gunars E. (Escondido CA) Anderson Richard R. (Encinitas CA), Threshold ligand-receptor assay.
  99. Buechler Kenneth F. (Santee CA) Valkirs Gunars E. (Escondido CA) Anderson Richard R. (Encinitas CA), Threshold ligand-receptor assay.
  100. Caplen, Julie E.; deSandro, Jean-Philippe J.; Koh, Joohyun, Two step etching process for an optical fiber preform.
  101. Astle, Thomas W., Ultra high throughput bioassay screening system.
  102. Duffy, David C.; Ferrell, Evan; Randall, Jeffrey D.; Rissin, David M.; Walt, David R., Ultra-sensitive detection of molecules on single molecule arrays.
  103. Duffy, David C.; Ferrell, Evan; Randall, Jeffrey D.; Rissin, David M.; Walt, David R., Ultra-sensitive detection of molecules on single molecule arrays.
  104. Duffy, David C.; Rissin, David M.; Walt, David R.; Fournier, David; Kan, Cheuk, Ultra-sensitive detection of molecules or particles using beads or other capture objects.
  105. Duffy, David C.; Rissin, David M.; Walt, David R.; Fournier, David; Kan, Cheuk, Ultra-sensitive detection of molecules or particles using beads or other capture objects.

이 특허를 인용한 특허 (5)

  1. Duffy, David C.; Song, Linan; Shan, Dandan; Zhao, Mingwei, Detection of DNA or RNA using single molecule arrays and other techniques.
  2. Walt, David R.; Rissin, David M., Methods and arrays for target analyte detection and determination of target analyte concentration in solution.
  3. Rissin, David M.; Fournier, David; Duffy, David C., Methods and systems for extending dynamic range in assays for the detection of molecules or particles.
  4. Walt, David R.; Rissin, David M., Methods for determining the concentration of an analyte in solution.
  5. Fournier, David; Campbell, Todd; Kan, Cheuk; Lawson, John; Rivnak, Andrew; Kagan, Michael; Duffy, David C., Systems, devices, and methods for ultra-sensitive detection of molecules or particles.
섹션별 컨텐츠 바로가기

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

AI-Helper 아이콘
AI-Helper
안녕하세요, AI-Helper입니다. 좌측 "선택된 텍스트"에서 텍스트를 선택하여 요약, 번역, 용어설명을 실행하세요.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.

선택된 텍스트