Provided is a coated implantable medical device, comprising: a substrate; and a coating disposed on said substrate, wherein said coating comprises at least one polymer and at least one pharmaceutical agent in a therapeutically desirable morphology and/or at least one active biological agent and opti
Provided is a coated implantable medical device, comprising: a substrate; and a coating disposed on said substrate, wherein said coating comprises at least one polymer and at least one pharmaceutical agent in a therapeutically desirable morphology and/or at least one active biological agent and optionally, one or more pharmaceutical carrying agents; wherein substantially all of pharmaceutical agent and/or active biological agent remains within said coating and on said substrate until the implantable device is deployed at an intervention site inside the body of a subject and wherein upon deployment of said medical device in the body of said subject a portion of said pharmaceutical agent and/or active biological agent is delivered at said intervention site along with at least a portion of said polymer and/or a at least a portion of said pharmaceutical carrying agents.
대표청구항▼
1. A medical device comprising: a substrate; anda coating on at least a portion of said substrate,wherein the coating comprises a plurality of layers, wherein at least one layer comprises a pharmaceutical agent that is crystalline,wherein the device is adapted to free at least a portion of the coati
1. A medical device comprising: a substrate; anda coating on at least a portion of said substrate,wherein the coating comprises a plurality of layers, wherein at least one layer comprises a pharmaceutical agent that is crystalline,wherein the device is adapted to free at least a portion of the coating from the substrate upon stimulation of the coating,wherein the coating comprises at least one of a non-absorbable polymer and a bioabsorbable polymer, and wherein the portion of the coating freed from the device comprises the at least one of the non-absorbable polymer and the bioabsorbable polymer, andwherein at least about 35% of the coating is adapted to be freed from the substrate upon stimulation that lasts at most 20 seconds. 2. The device of claim 1, wherein the crystalline pharmaceutical agent is not a microcapsule. 3. The device of claim 1, wherein the substrate comprises a balloon. 4. The device of claim 1, wherein the pharmaceutical agent and a polymer are in the same layer, in separate layers, or form overlapping layers. 5. The device of claim 1, wherein the plurality of layers comprise five layers deposited as follows: a first polymer layer, a first pharmaceutical agent layer, a second polymer layer, a second pharmaceutical agent layer and a third polymer layer. 6. The device of claim 1, wherein the pharmaceutical agent comprises a macrolide immunosuppressive drug. 7. The device of claim 6, wherein the macrolide immunosuppressive drug comprises one or more of rapamycin, 40-0-(2-Hydroxyethyl)rapamycin (everolimus), 40-0-Benzyl-rapamycin, 40-0-(4′-Hydroxymethyl)benzyl-rapamycin, 40-0-[4′-(1,2-Dihydroxyethyl)]benzyl-rapamycin, 40-0-Allyl-rapamycin, 40-0-[3′-(2,2-Dimethyl-1,3-dioxolan-4(S)-yl)-prop-2′-en-1′-yl]-rapamycin, (2′:E,4′S)-40-0-(4′,5′-Dihydroxypent-2′-en-1′-yl)-rapamycin 40-0-(2-Hydroxy)ethoxycar-bonylmethyl-rapamycin, 40-0-(3-Hydroxy)propyl-rapamycin, 40-0-(6-Hydroxy)hexyl-rapamycin, 40-0-[2-(2-Hydroxy)ethoxy]ethyl-rapamycin, 40-0-[(3S)-2,2-Dimethyldioxolan-3-yl]methyl-rapamycin, 40-0-[(2S)-2,3-Dihydroxyprop-1-yl]-rapamycin, 40-0-(2-Acetoxy)ethyl-rapamycin, 40-0-(2-Nicotinoyloxy)ethyl-rapamycin, 40-0-[2-(N-Morpholino)acetoxy]ethyl-rapamycin, 40-0-(2-N-Imidazolylacetoxy)ethyl-rapamycin, 40-0-[2-(N-Methyl-N′-piperazinyl)acetoxy]ethyl-rapamycin, 39-0-Desmethyl-39,40-0,0-ethylene-rapamycin, (26R)-26-Dihydro-40-0-(2-hydroxy)ethyl-rapamycin, 28-0-Methyl-rapamycin, 40-0-(2-Aminoethyl)-rapamycin, 40-0-(2-Acetaminoethyl)-rapamycin, 40-0-(2-Nicotinamidoethyl)-rapamycin, 40-0-(2-(N-Methyl-imidazo-2′-ylcarbethoxamido)ethyl)-rapamycin, 40-0-(2-Ethoxycarbonylaminoethyl)-rapamycin, 40-0-(2-Tolylsulfonamidoethyl)-rapamycin, 40-0-[2-(4′,5′-Dicarboethoxy-1′,2′,3′-triazol-1′-yl)-ethyl]-rapamycin, 42-Epi-(tetrazolyl)rapamycin (tacrolimus), and 42-[3-hydroxy-2-(hydroxymethyl)-2-methylpropanoate]rapamycin (temsirolimus). 8. The device of claim 1, wherein the pharmaceutical agent is rapamycin. 9. The device of claim 1, wherein the pharmaceutical agent is at least 50% crystalline. 10. The device of claim 1, wherein the pharmaceutical agent is at least 75% crystalline. 11. The device of claim 1, wherein the pharmaceutical agent is at least 90% crystalline. 12. The device of claim 1, wherein the coating is formed on said substrate by a process comprising at least one of: depositing a polymer by an e-RESS, an e-SEDS, or an e-DPC process, and depositing the pharmaceutical agent by an e-RESS, an e-SEDS, or an e-DPC process. 13. The device of claim 12, wherein the process of forming the coating provides improves adherence of the coating to the substrate prior to deployment of the device and facilitates dissociation of said coating from said substrate upon stimulation. 14. The device of claim 1, wherein the device is adapted to transfer less than about 10% of the coating absent stimulation of the coating. 15. The device of claim 1, wherein the coating comprises a bioabsorbable polymer. 16. The device of claim 15, wherein the bioabsorbable polymer comprises at least one of: Polylactides (PLA); PLGA (poly(lactide-co-glycolide); Polyanhydrides; Polyorthoesters; Poly(N-(2-hydroxypropyl) methacrylamide); DLPLA-poly(dl-lactide); LPLA-poly(l-lactide); PGA-polyglycolide; PDQ-poly(dioxanone); PGA-TMC-poly(glycolide-co-trimethylene carbonate); PGA-LPLA-poly(l-lactide-co-glycolide); PGA-DLPLA-poly(dl-lactide-co-glycolide); LPLA-DLPLA-poly(l-lactide-co-dl-lactide); and PDO-PGA-TMC-poly(glycolide-co-trimethylene carbonate-co-dioxanone), and combinations, copolymers, and derivatives thereof. 17. The device of claim 15, wherein the bioabsorbable polymer comprises between 1% and 95% glycolic acid content PLGA-based polymer. 18. The device of claim 1, wherein at least about 50% of the coating is adapted to be freed from the substrate upon stimulation. 19. The device of claim 1, wherein the device is adapted to free all of the coating upon a single stimulation of the coating.
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