Methods of using adipose tissue-derived cells in the treatment of the lymphatic system and malignant disease
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
C12N-005/00
A61K-035/28
A61K-035/35
C12N-005/078
C12N-005/071
A61K-045/06
A61K-035/12
출원번호
US-0336755
(2014-07-21)
등록번호
US-9486484
(2016-11-08)
발명자
/ 주소
Alfonso, Zeni
Fraser, John K.
출원인 / 주소
Cytori Therapeutics, Inc.
대리인 / 주소
Knobbe Martens Olson & Bear LLP
인용정보
피인용 횟수 :
0인용 특허 :
117
초록▼
Aspects of the invention provides methods for preparing and using adipose-tissue-derived stem and progenitor cells, adipose-tissue-derived lymphatic endothelial cells, and cells capable of differentiating into lymphatic endothelial cells to treat disorders of the lymphatic system and to modulate exp
Aspects of the invention provides methods for preparing and using adipose-tissue-derived stem and progenitor cells, adipose-tissue-derived lymphatic endothelial cells, and cells capable of differentiating into lymphatic endothelial cells to treat disorders of the lymphatic system and to modulate expansion, repair, and/or regeneration of the lymphatic system. The invention further provides using adipose-tissue-derived lymphatic endothelial cells and cells capable of differentiating into lymphatic endothelial cells for delivery of therapeutic agents to tumor cells as a means for treating malignant disease, and assays to screen for drugs that modulate lymphatic system expansion, repair or regeneration.
대표청구항▼
1. A method of treating edema in a subject in need thereof, comprising: identifying a subject having edema; andadministering to said subject an isolated population of adipose-derived cells comprising lymphatic endothelial cells (LECs) and pre-LECs, wherein greater than 5% of said population of adipo
1. A method of treating edema in a subject in need thereof, comprising: identifying a subject having edema; andadministering to said subject an isolated population of adipose-derived cells comprising lymphatic endothelial cells (LECs) and pre-LECs, wherein greater than 5% of said population of adipose-derived cells express FLT-4. 2. The method of claim 1, wherein the edema is lymphedema. 3. The method of claim 1, wherein said subject has a wound. 4. The method of claim 3, wherein said wound is a burn. 5. The method of claim 3, wherein said wound is a skin wound following grafting. 6. The method of claim 3, wherein said wound is a radiation wound. 7. The method of claim 1, wherein said isolated population of adipose-derived cells comprising lymphatic endothelial cells (LECs) and pre-LECs is administered by injection into a lymph node. 8. The method of claim 1, wherein said isolated population of adipose-derived cells comprising lymphatic endothelial cells (LECs) and pre-LECs is administered by injection into lymphatic vessels. 9. The method of claim 1, wherein said isolated population of adipose-derived cells comprising lymphatic endothelial cells (LECs) and pre-LECs is administered by injection into tissue space. 10. The method of claim 1, wherein greater than 5% of said population of adipose-derived cells also express CD45. 11. The method of claim 1, wherein greater than 5% of said population of adipose-derived cells also express CD34. 12. The method of claim 1, wherein greater than 5% of said population of adipose-derived cells also express CD14. 13. The method of claim 1, wherein said isolated population of adipose-derived cells is mixed with an additive prior to administering the adipose-derived cells to the subject. 14. The method of claim 13, wherein said additive is selected from the group consisting of an anti-apoptosis agent, a growth factor, a tissue graft, a portion of unprocessed adipose tissue, a population of adipose-derived stem cells, a population of adipose-derived endothelial cells, population of adipose-derived progenitor cells, a cell differentiation factor. 15. The method of claim 1, wherein said identification comprises examination of a tissue biopsy, fluorescence micorlymphangiography, computed tomography, X-ray lymphography, dual0site fluorescence angiography, isotope lymphography, laser-Doppler analysis, magnetic resonance imaging, ultrasonography, or any combination thereof. 16. The method of claim 1, wherein said isolated population of adipose-derived cells is not cultured prior to providing the isolated population of adipose-derived cells to the subject. 17. The method of claim 1, wherein said isolated population of adipose-derived cells is cultured in vitro prior to providing the isolated population of adipose-derived cells to the subject. 18. The method of claim 1, wherein said isolated population of adipose-derived cells is obtained by processing adipose tissue in a cell processing device configured to maintain a closed pathway. 19. The method of claim 1, further comprising analyzing said edema following the administration of said isolated population of adipose-derived cells. 20. The method of claim 1, wherein the isolated population of adipose-derived cells comprising LECs and pre-LECs is cryopreserved.
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