Methods of using regenerative cells to treat a burn
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-045/00
A61K-035/28
A61K-035/12
C12N-005/0775
C12N-005/071
A61K-035/36
A61K-035/44
A61K-038/18
A61K-045/06
출원번호
US-0180589
(2014-02-14)
등록번호
US-9492483
(2016-11-15)
발명자
/ 주소
Fraser, John K.
Hedrick, Marc H.
Daniels, Eric
출원인 / 주소
Cytori Therapeutics, Inc.
대리인 / 주소
Knobbe Martens Olson & Bear LLP
인용정보
피인용 횟수 :
0인용 특허 :
116
초록▼
Cells present in adipose tissue are used to promote wound healing in a patient. Methods of treating patients include processing adipose tissue to deliver a concentrated amount of regenerative cells obtained from the adipose tissue to a patient. The methods may be practiced in a closed system so that
Cells present in adipose tissue are used to promote wound healing in a patient. Methods of treating patients include processing adipose tissue to deliver a concentrated amount of regenerative cells obtained from the adipose tissue to a patient. The methods may be practiced in a closed system so that the regenerative cells are not exposed to an external environment prior to being administered to a patient. Accordingly, in a preferred method, cells present in adipose tissue are placed directly into a recipient along with such additives necessary to promote, engender or support a therapeutic benefit.
대표청구항▼
1. A method of treating a burn in a subject in need thereof, comprising: identifying a subject with a burn; andadministering a therapeutically effective amount of a concentrated population of adipose-derived regenerative cells comprising adipose-derived stem cells and endothelial progenitor cells to
1. A method of treating a burn in a subject in need thereof, comprising: identifying a subject with a burn; andadministering a therapeutically effective amount of a concentrated population of adipose-derived regenerative cells comprising adipose-derived stem cells and endothelial progenitor cells to said subject sufficient to accelerate the healing of said burn wherein said concentrated population of adipose-derived regenerative cells is obtained by acquiring an adipose tissue sample, separating away adipocytes and connective tissue, and washing and concentrating said adipose-derived regenerative cells. 2. The method of claim 1, wherein the concentrated population of adipose-derived regenerative cells has not been cultured. 3. The method of claim 1, wherein the concentrated population of adipose-derived regenerative cells is obtained from adipose tissue of the subject to whom the cells are administered. 4. The method of claim 1, wherein said administering step comprises applying the concentrated population of adipose-derived regenerative cells directly to the burn. 5. The method of claim 1, wherein said administering step comprises subcutaneous delivery. 6. The method of claim 1, wherein said administering step comprises dermal delivery. 7. The method of claim 1, wherein said administering step comprises intravascular delivery. 8. The method of claim 1, wherein said administration step comprises administering multiple doses of said concentrated population of adipose-derived regenerative cells. 9. The method of claim 1, further comprising: providing adipose tissue to a self-contained adipose tissue processing unit comprising: a tissue collecting container configured to receive and fully or partially disaggregate adipose tissue, wherein said tissue collecting container is coupled to a cell collection container wherein said coupling defines a closed system in which said fully or partially disaggregated adipose tissue directed from tissue collecting container to cell collection container is not exposed to the external environment; and wherein said cell collection container, further comprises a cell concentrator that facilitates separation of the cells in a suspension; andan outlet that is structured to permit said concentrated population of adipose-derived regenerative cells comprising stem and progenitor to be removed from said adipose tissue processing unit; andobtaining the concentrated population adipose-derived regenerative cells from said self-contained adipose tissue processing unit. 10. The method of claim 1, wherein the therapeutically effective amount of the concentrated population of adipose-derived regenerative cells comprises a minimum concentration of between 1×105 and 1×107 adipose-derived stem cells. 11. The method of claim 1, wherein the concentrated population of adipose-derived regenerative cells further comprises an additive. 12. The method of claim 10, wherein said additive is selected from the group consisting of a cell differentiation factor, a growth promoter, an immunosuppressive agent, a medical device, or a combination thereof. 13. The method of claim 10, wherein said additive is selected from the group consisting of other cells, tissue, and tissue fragments. 14. The method of claim 10, wherein said additive comprises an angiogenic factor, or an arteriogenic factor. 15. The method of claim 1, wherein said concentrated population of adipose-derived regenerative cells further comprises endothelial precursor cells. 16. The method of claim 1, wherein said concentrated population of adipose-derived regenerative cells is applied to a biocompatible matrix. 17. The method of claim 1, wherein said concentrated population of adipose-derived regenerative cells applied to a bandage. 18. The method of claim 1, further comprising: performing excisional lipectomy to obtain adipose tissue from said subject; andprocessing said adipose tissue to obtain said concentrated population of adipose-derived regenerative cells. 19. The method of claim 1, further comprising: performing lipoaspiration to obtain adipose tissue from said subject; andprocessing said adipose tissue to obtain said concentrated population of adipose-derived regenerative cells. 20. The method of claim 1, wherein said concentrated population of adipose-derived regenerative cells is cryopreserved. 21. The method of claim 16, wherein the biocompatible matrix comprises a synthetic or biological scaffold. 22. The method of claim 1, wherein said concentrated population of adipose-derived cells is administered via an artificial or natural tissue scaffold. 23. The method of claim 1, wherein said concentrated population of adipose-derived regenerative cells in not exposed to the external environment prior to the administration step.
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