Modular biocompatible materials for medical devices and uses thereof
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
C01B-021/26
A61K-033/00
A61L-027/54
A61L-029/16
A61L-031/16
C01B-021/24
A61L-029/06
A61L-031/06
A61L-029/14
A61L-031/14
출원번호
US-0192691
(2014-02-27)
등록번호
US-9493352
(2016-11-15)
발명자
/ 주소
Reynolds, Melissa M.
Reynolds, Benjamin P.
출원인 / 주소
COLORADO STATE UNIVERSITY RESEARCH FOUNDATION
대리인 / 주소
Faegre Baker Daniels LLP
인용정보
피인용 횟수 :
0인용 특허 :
8
초록▼
The present disclosure is directed to a method of producing nitric oxide comprising (i) providing a composition comprising a metal-organic framework, and (ii) exposing the composition to a nitric oxide-releasing compound. The disclosure also is directed to compositions, coatings, and medical devices
The present disclosure is directed to a method of producing nitric oxide comprising (i) providing a composition comprising a metal-organic framework, and (ii) exposing the composition to a nitric oxide-releasing compound. The disclosure also is directed to compositions, coatings, and medical devices comprising a metal-organic framework.
대표청구항▼
1. A method of producing nitric oxide comprising: exposing a composition to a physiological fluid including a nitric oxide-release compound, the composition comprising a three dimensional metal-organic framework; andcontinuously producing nitric oxide from the nitric oxide-releasing compound via a c
1. A method of producing nitric oxide comprising: exposing a composition to a physiological fluid including a nitric oxide-release compound, the composition comprising a three dimensional metal-organic framework; andcontinuously producing nitric oxide from the nitric oxide-releasing compound via a catalytic reaction catalyzed by the three dimensional metal-organic framework, wherein the three dimensional metal-organic framework comprises Cu(1,3,5-benzenetristetrazolate). 2. The method of claim 1, wherein the metal-organic framework has a porous structure. 3. The method of claim 1, wherein the metal-organic framework has a porous structure comprising pores having an average size of about 5 Å to about 500 Å in diameter. 4. The method of claim 1, wherein the nitric oxide-releasing compound comprises a functional group selected from the group consisting of S-nitrosothiol, diazeniumdiolate, nitrate, nitrite, nitroso, and nitrosyl. 5. The method of claim 1, wherein the exposing step comprises contacting the composition with fluids, tissues, or cells. 6. The method of claim 1, wherein the exposing step comprises contacting the composition with blood. 7. The method of claim 1, wherein the nitric oxide-releasing compound is present in fluids, tissues, or cells. 8. The method of claim 1, wherein the nitric oxide-releasing compound is present in blood. 9. The method of claim 1, wherein the composition comprises a therapeutic agent. 10. The method of claim 1, wherein the composition comprises a therapeutic agent selected from the group consisting of anti-thrombotic agents and antimicrobial agents. 11. The method of claim 1, wherein the composition comprises a polymer. 12. The method of claim 1, wherein the composition comprises a polymer selected from the group consisting of polyurethane (PU), polyesters, polyethers, silicones, silicates, poly(vinyl chloride) (PVC), acrylates, methacylates, dextran, synthetic rubber (cis-polyisoprene), polyvinyl acetate, Bakelite, polychloroprene (neoprene), nylon, polystyrene, polyethylene, polypropylene, polyacrylonitrile, polyvinyl butyral (PVB), poly(vinylidene chloride), fluorinated polymers, polytetrafluoroethylene (PTFE), and mixtures and copolymers thereof.
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이 특허에 인용된 특허 (8)
Reynolds, Melissa M.; Reynolds, Benjamin P., Biocompatible materials for medical devices.
Fitzhugh, Anthony L.; Cheng, Peiwen; Saavedra, Joseph; Cafferata, Robert; Hendriks, Marc; Keefer, Larry K.; Tedeschi, Eugene; Verhoeven, Michel I. P. M., Nitric oxide-releasing metallic medical devices.
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