Compounds and methods for preventing or treating sensory hair cell death
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
C07D-455/04
C07D-495/18
A61K-031/439
A61K-031/7036
출원번호
US-0017472
(2016-02-05)
등록번호
US-9493482
(2016-11-15)
발명자
/ 주소
Simon, Julian
Johnson, Graham
Rubel, Edwin
Raible, David
Gonzalez, Mario D.
Meltzer, Peter C.
Miao, Weishi
출원인 / 주소
University of Washington
대리인 / 주소
Wilson Sonsini Goodrich & Rosati
인용정보
피인용 횟수 :
0인용 특허 :
23
초록▼
Disclosed herein are compounds, and pharmaceutical compositions that include such compounds, for preventing or treating hearing loss. The compounds and pharmaceutical compositions described herein prevent or treat hair cell death. In addition, the compounds and pharmaceutical compositions described
Disclosed herein are compounds, and pharmaceutical compositions that include such compounds, for preventing or treating hearing loss. The compounds and pharmaceutical compositions described herein prevent or treat hair cell death. In addition, the compounds and pharmaceutical compositions described herein protect against kidney damage in an individual receiving an aminoglycoside antibiotic. Methods of using the compounds, alone or in combination with other therapeutic agents, are also disclosed.
대표청구항▼
1. A compound having the structure of Formula (I): Formula (I); wherein:R1 is aryl or heteroaryl, wherein aryl and heteroaryl are optionally substituted with one or more R4;R2 is H, C1-C6alkyl, C1-C6alkyl-OR6, C1-C6alkylC3-C6cycloalkyl, C1-C6alkylC2-C7heterocycloalkyl, C1-C6alkyl-CO2R6, optionally
1. A compound having the structure of Formula (I): Formula (I); wherein:R1 is aryl or heteroaryl, wherein aryl and heteroaryl are optionally substituted with one or more R4;R2 is H, C1-C6alkyl, C1-C6alkyl-OR6, C1-C6alkylC3-C6cycloalkyl, C1-C6alkylC2-C7heterocycloalkyl, C1-C6alkyl-CO2R6, optionally substituted C1-C6alkylaryl, or optionally substituted C1-C6alkylheteroaryl;each R4 is independently selected from F, Cl, Br, I, —CN, —NO2, —CF3, —OR9, —OCF3,—NR8R9, —C(O)R10, —CO2R9, —C(O)NR8R9, —N(R8)C(O)R10, —N(R8)CO2R10, —NHS(O)2R10, —S(O)2NR8R9, C1-C6alkyl, C3-C6cycloalkyl, C1-C6heteroalkyl, C1-C6haloalkyl, C2-C7heterocycloalkyl, aryl, and heteroaryl;R6 is H, or C1-C6alkyl;R8 is H, or C1-C6alkyl;R9 is H, C1-C6alkyl, C3-C6cycloalkyl, C2-C7heterocycloalkyl, aryl, heteroaryl, C1-C6alkylaryl, or C1-C6alkylheteroaryl;R10 is C1-C6alkyl, C3-C6cycloalkyl, C2-C7heterocycloalkyl, aryl, heteroaryl, C1-C6alkylaryl, or C1-C6alkylheteroaryl;R11 is H, C1-C6alkyl, C1-C6haloalkyl, C3-C6cycloalkyl, C2-C7heterocycloalkyl, aryl, heteroaryl, C1-C6alkylC3-C6cycloalkyl, C1-C6alkylaryl, or C1-C6alkylheteroaryl; andR12 is H, C1-C6alkyl, C1-C6haloalkyl, C3-C6cycloalkyl, C2-C7heterocycloalkyl, aryl, heteroaryl, C1-C6alkylC3-C6cycloalkyl, C1-C6alkylaryl, or C1-C6alkylheteroaryl; or R11 and R12 together with the nitrogen to which they are attached form an optionally substituted C2-C7heterocycloalkyl ring; or a pharmaceutically acceptable salt thereof. 2. The compound of claim 1 wherein R11 and R12 are each H. 3. The compound of claim 2 wherein R1 is aryl optionally substituted with one or more R4. 4. The compound of claim 3 wherein R1 is phenyl optionally substituted with one or more R4. 5. The compound of claim 4 wherein R1 is phenyl substituted with one or more R4, wherein each R4 is independently selected from F, Cl, Br, I, —CN, —NO2, —CF3, —OR9, —OCF3, —NR8R9, —C(O)R10, —CO2R9, C1-C6alkyl, and C1-C6haloalkyl. 6. The compound of claim 5 wherein R1 is phenyl substituted with one R4, wherein R4 is selected from F, Cl, Br, I, —CN, —CF3, —OR9, —OCF3, —C(O)R10, —CO2R9, and C1-C6alkyl. 7. The compound of claim 6 wherein R1 is 4-chlorophenyl. 8. The compound of claim 7 wherein R2 is H. 9. The compound of claim 7 wherein R2 is C1-C6alkyl. 10. The compound of claim 9 wherein R2 is —CH3. 11. The compound of claim 1 having the structure: or a pharmaceutically acceptable salt thereof. 12. A pharmaceutical composition comprising a therapeutically effective amount of a compound of claim 1, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient. 13. The pharmaceutical composition of claim 12 further comprising an aminoglycoside antibiotic.
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