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Human antigen binding proteins that bind β-klotho, FGF receptors and complexes thereof

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-039/395
  • C07K-016/40
  • C07K-014/71
  • C07K-016/18
  • C07K-016/28
  • A61K-039/00
출원번호 US-0012939 (2016-02-02)
등록번호 US-9493577 (2016-11-15)
발명자 / 주소
  • Hu, Shaw-Fen Sylvia
  • Foltz, Ian Nevin
  • King, Chadwick Terence
  • Li, Yang
  • Arora, Taruna
출원인 / 주소
  • Hu, Shaw-Fen Sylvia
인용정보 피인용 횟수 : 0  인용 특허 : 67

초록

The present invention provides compositions and methods relating to or derived from antigen binding proteins activate FGF21-mediated signaling. In embodiments, the antigen binding proteins specifically bind to (i) β-Klotho; (ii) FGFR1c, FGFR2c, FGFR3c or FGFR4; or (iii) a complex comprising β-Klotho

대표청구항

1. A method of treating a condition in a subject in need thereof comprising administering a therapeutically effective amount of an antigen binding protein that induces FGF21-mediated signaling and comprises a heavy chain variable region comprising complementarity determining regions (CDRs) comprisin

이 특허에 인용된 특허 (67)

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