Method of vaccine delivery via microneedle arrays
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-039/02
A61K-039/00
A61K-039/07
A61B-017/20
A61K-009/00
A61M-037/00
출원번호
US-0549442
(2014-11-20)
등록번호
US-9498524
(2016-11-22)
발명자
/ 주소
Ghartey-Tagoe, Esi
Wendorf, Janet
Williams, Steve
Singh, Parminder
Worsham, Robert Wade
Trautman, Joseph C.
Bayramov, Danir
Bowers, Danny Lee
Klemm, Andrew Richard
Klemm, Steven Richard
Chen, Guohua
출원인 / 주소
Corium International, Inc.
대리인 / 주소
Mahoney, Jacqueline F.
인용정보
피인용 횟수 :
3인용 특허 :
232
초록▼
A microprojection array is provided, comprising an approximately planar base and a plurality of microprojections, wherein the array comprises a vaccine and a polymeric material. The array may have multiple layers. The vaccine may be placed in only one layer. In another embodiment of the invention, a
A microprojection array is provided, comprising an approximately planar base and a plurality of microprojections, wherein the array comprises a vaccine and a polymeric material. The array may have multiple layers. The vaccine may be placed in only one layer. In another embodiment of the invention, a method of preventing a disease is provided, comprising insertion into the skin of a patient an array of microprojections comprising a layer which comprises a vaccine for that disease and a polymer.
대표청구항▼
1. A method of preventing a disease, comprising insertion into the skin of a patient an array of microprojections comprising a layer which comprises a vaccine for that disease and a polymer. 2. The method of claim 1, wherein the vaccine is directed against anthrax, diphtheria/tetanus/pertussis, hepa
1. A method of preventing a disease, comprising insertion into the skin of a patient an array of microprojections comprising a layer which comprises a vaccine for that disease and a polymer. 2. The method of claim 1, wherein the vaccine is directed against anthrax, diphtheria/tetanus/pertussis, hepatitis A, hepatitis B, Haemophilus influenzae type b, human papillomavirus, influenza, Japanese encephalitis, measles/mumps/rubella, meningococcal diseases, pneumococcal diseases, polio, rabies, rotavirus, shingles, smallpox, tetanus/diphtheria, tetanus/diphtheria/pertussis, typhoid, varicella, or yellow fever. 3. The method of claim 1, wherein the vaccine lacks an adjuvant. 4. The method of claim 1, wherein the microprojections are biodegradable at least in part. 5. The method of claim 1, wherein the microprojections are left in the skin for no more than 30 minutes. 6. The method of claim 1, wherein the array is applied to the patient's skin by means of an applicator. 7. The method of claim 6, wherein the applicator is spring-loaded. 8. A method of preventing a disease, comprising introducing into the skin at least about 50 discrete deposits comprising a vaccine for that disease and a polymer. 9. The method of claim 8, wherein the discrete deposits are projections which form part of an array. 10. The method of claim 9, wherein the projections detach from the array. 11. The method of claim 8, wherein each discrete deposit comprises at least about 0.05 ng of said vaccine. 12. The method of claim 8, where the initial concentration of said vaccine in each discrete deposit is at least about 0.5% by weight. 13. The method of claim 8, wherein where the initial concentration of said vaccine in each discrete deposit is at least about 5% by weight. 14. The method of claim 8, wherein the polymer and the vaccine are mixed together within each deposit. 15. The method of claim 8, wherein the discrete deposits are at a density no lower than about 50 deposits per cm2 of skin surface.
연구과제 타임라인
LOADING...
LOADING...
LOADING...
LOADING...
LOADING...
이 특허에 인용된 특허 (232)
Laura Graves Spalding VanRijswijck ; Gretchen Louise Elder ; Donald Carroll Roe, Absorbent articles having cuffs and topsheet with skin care composition(s) disposed thereon.
Fishman Henry (5173 Linnean Ter. NW. Washington DC 20008) Johnson Gary D. (New York NY) Smith Jeffrey T. (Arlington VA) Holtz Leonard (Oceanside NY), Allergy testing apparatus and method.
Drelich Arthur (Plainfield NJ) Bassett Alton H. (Princeton NJ) James William (East Windsor NJ) Kennette John W. (Somerville NJ) McMeekin Linda J. (Bound Book NJ), Apertured non-woven fabric.
Trautman, Joseph C.; Keenan, Richard L.; Samiee, Ahmad P.; Lin, WeiQi; Cormier, Michel J. N.; Matriano, James A.; Daddona, Peter E., Apparatus and method for piercing skin with microprotrusions.
Trautman,Joseph C.; Keenan,Richard L.; Samiee,Ahmad P.; Lin,WeiQi; Cormier,Michel J. N.; Matriano,James A.; Daddona,Peter E., Apparatus and method for piercing skin with microprotrusions.
Trautman,Joseph C.; Keenan,Richard L.; Samiee,Ahmad P.; Lin,WeiQi; Cormier,Michel J. N.; Matriano,James A.; Daddona,Peter E., Apparatus and method for piercing skin with microprotrusions.
Yuzhakov Vadim Vladimirovich ; Sherman Faiz Feisal ; Owens Grover David ; Gartstein Vladimir, Apparatus and method for using an intracutaneous microneedle array.
Hofmann Gunter A. ; Dev Sukhendu B. ; Dimmer Steven C. ; Levatter Jeffrey I. ; Nanda Gurvinder S., Apparatus for addressing needle array electrodes for electroporation therapy.
Saito Shiro (Tokoname) Kawamoto Ryuichi (Tokoname) Kondo Mineharu (Tokoname) Sakakibara Shigeru (Tokoname JPX), Apparatus for detecting ingredient in urine, a toilet stool equipped with a urine detecting device and a room for urine.
Trautman, Joseph C.; Worsham, Robert Wade; Bayramov, Danir F.; Bowers, Danny Lee; Klemm, Steven Richard; Singh, Parminder, Applicators for microneedles.
Gelfer Ala (600 S. Curson #326 Los Angeles CA 90036) Gelfer Arkadiy (600 S. Curson #326 Los Angeles CA 90036) Gelfer Stan (1022 N. Vista St. #5 Los Angeles CA 90046), Body treatment pad having a multiple number of sharpened skin-penetration protuberances.
Chester Martin H. (25310 Tierra Grande Dr. Carmel CA 93921) Norman Cary A. (440 Juniper Ave. Pacific Grove CA 93950), Clamp-on nerve stimulator and locator.
Lastovich, Alexander G.; Fentress, James K.; Griggs, Julia; Pettis, Ronald J.; Sutter, Diane; Martin, Frank E.; Haider, M. Ishaq, Device and method for delivering or withdrawing a substance through the skin.
Cormier,Michel J. N.; Neukermans,Armand P.; Block,Barry; Theeuwes,Felix T.; Amkraut,Alfred A., Device and method for enhancing transdermal flux of agents being delivered or sampled.
Prausnitz, Mark R.; Allen, Mark G.; Henry, Sebastien; McAllister, Devin V.; Ackley, Donald E.; Jackson, Thomas, Devices and methods for enhanced microneedle penetration of biological barriers.
Wong Ooi (Fremont CA) Nguyen Thuytien N. (Hayward CA), Enhancement of transdermal drug delivery using monoalkyl phosphates and other absorption promoters.
Lum Paul ; Leonard Leslie A. ; Verdonk Edward D. ; Freeman Dominique M. ; Greenstein Michael ; Keely-Templin Catherine, Extraction and transportation of blood for analysis.
Bishop Delmar J. (Hamilton OH), Film forming structure for uniformly debossing and selectively aperturing a resilient plastic web and method for its con.
Cusack Robert F. (Edison NJ) Mintz Michael D. (Edison NJ), Fluid sample collection and delivery system and methods particularly adapted for body fluid sampling.
Safabash Jason H. ; McConnell Susan M. ; Adair Randy W. ; Funderburk Jeffery V. ; Marano April A. ; Field Jeffrey F., Insertion device for an insertion set and method of using the same.
Ahr Nicholas A. (Cincinnati OH) Louis Paul R. (Cincinnati OH) Mullane ; Jr. William I. (Cincinnati OH) Ouellette William R. (Cincinnati OH), Macroscopically expanded three-dimensional plastic web exhibiting non-glossy visible surface and cloth-like tactile impr.
Gore Gerald W. (Placentia CA) Milner ; Jr. Philip H. (Newport Beach CA) Petersen Gordon A. (Fountain Valley CA), Method for making perforated articles.
Sherman, Faiz Feisal; Gartstein, Vladimir, Method for manufacturing microstructures having hollow microelements using fluidic jets during a molding operation.
Calanchi Massimo,ITX ; Zema Marco,ITX ; Brunetti Gabriele,ITX ; Giorgetti Enzo,ITX, Method for targeted and controlled release of drugs in the intestinal tract and more particularly in the colon.
Guy Richard ; Rao Girish ; Glikfeld Peretz,ILX ; Cullander Christopher ; Hinz Robert S., Method for the iontophoretic non-invasive determination of the in vivo concentration level of glucose.
Guy Richard (San Francisco CA) Rao Girish (San Francisco CA), Method for the iontophoretic non-invasive-determination of the in vivo concentration level of an inorganic or organic su.
Bracht Stefan,DEX, Method for the low-waste manufacture of diskoid moulded bodies containing active ingredients, and transdermal therapeutic systems containing same.
Rowland William P. (Southington CT) Martin David C. (Berlin CT), Method of casting a microstructure sheet having an array of prism elements using a reusable polycarbonate mold.
Turi Mordechai (Princeton Junction NJ) DeRossett Edmund Z. (Mercerville NJ) Yang Ching-Yun M. (Princeton Junction NJ), Method of forming textile-like apertured plastic films.
Hofmann Gunter A. ; Dev Sukhendu B. ; Dimmer Steven C. ; Levatter Jeffrey I. ; Nanda Gurvinder S., Method of programming an array of needle electrodes for electroporation therapy of tissue.
Ivanov Konstantin ; Reinhardt William ; Routh Shakti ; Pohle Michael, Microbial barrier vented package for sterile medical devices and method of packaging.
Yuzhakov, Vadim Vladimirovich; Gartstein, Vladimir; Owens, Grover David, Microneedle apparatus used for marking skin and for dispensing semi-permanent subcutaneous makeup.
Delmore, Michael D.; Fleming, Patrick R.; Huntley, Douglas A.; Keister, Jamieson C.; Thomas, Cristina U.; Ferber, Richard H., Microneedle arrays and methods of manufacturing the same.
Hofmann Gunter A. ; Dev Sukhendu B. ; Dimmer Steven C. ; Levatter Jeffrey I. ; Nanda Gurvinder S., Minimally invasive apparatus and method to electroporate drugs and genes into tissue.
Curro John J. (Cincinnati OH) Baird James C. (Cincinnati OH) Gerth Donald L. (Cincinnati OH) Vernon George M. (West Chester OH) Linman E. Kelly (Cincinnati OH), Multi-phase process for debossing and perforating a polymeric web to coincide with the image of one or more three-dimens.
Ginaven Robert O. (Encinitas CA) Facciotti Daniel (Davis CA), Needle array and method of introducing biological substances into living cells using the needle array.
Lee Abraham P. (1428 Whitecliff Way Walnut Creek CA 94596) Northrup M. Allen (923 Creston Rd. Berkeley CA 94708) Ahre Paul E. (1299 Gonzaga Ct. Livermore CA 94550) Dupuy Peter C. (1736 Waldo Ct. Mode, Polymer micromold and fabrication process.
Curro John J. (Cincinnati OH) Trusty Alan J. (Bethel OH) Vernon George M. (West Chester OH), Production of formed material by solid-state formation with a high-pressure liquid stream.
Lothar W. Kleiner ; Robert M. Gale ; Randall G. Berggren ; Gilbert T. Tong ; Guohua Chen ; Keith E. Dionne ; Paul R. Houston, Rate controlling membranes for controlled drug delivery devices.
Turner Josephine S. (Kettleby CAX) Murray D. Gary (Willowdale CAX) Zuccolin John D. (Stouffville CAX) Li Ruey S. (Thornhill CAX), Substance transfer system for topical application.
Lyons Julie W. (North Bend OH) Battrell Charles F. (Cincinnati OH) Ouellette William R. (Cincinnati OH) Curro John J. (Cincinnati OH), Substantially fluid-impervious microbubbled polymeric web exhibiting low levels of noise when subjected to movement.
Allison Kenneth C. (Crystal Lake IL) Allison Roger D. (Bensenville IL) Allison Charlotte C. (Crystal Lake IL), Trans-dermal medication application cell.
Lee Hai Bang (Taejeon KRX) Shin Bung Chul (Taejeon KRX), Transdermal administration method of protein or peptide drug and its administration device thereof.
Santus Giancarlo (Milan CA ITX) Kim Aeri (Mountain View CA) Francoeur Michael L. (Los Altos CA) Bremer Ulrike (Menlo Park CA), Transdermal delivery of alpha adrenoceptor blocking agents.
Cartmell James V. (Xenia OH) Sturtevant Wayne R. (Centerville OH) Bausmith ; III William E. (Batavia OH) Wolf Michael L. (West Milton OH), Wound dressing product containing a porous layer.
Singh, Parminder; Worsham, Robert Wade; Trautman, Joseph C.; Bayamov, Danir; Bowers, Danny Lee; Klemm, Andrew Richard; Klemm, Steven Richard; Chen, Guohua, Solvent-cast microprotrusion arrays containing active ingredient.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.