Methods of manufacture and use of implantable pressure-actuated drug delivery systems
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-009/52
A61F-002/82
A61K-009/00
A61L-031/16
A61M-031/00
출원번호
US-0179835
(2014-02-13)
등록번호
US-9504586
(2016-11-29)
발명자
/ 주소
Hwang, Chao-Wei
Tomey, Hala J.
Resar, Jon R.
Matteson, III, Robert C.
Coles, Jr., George L.
Benkoski, Jason J.
Trexler, Morgana M.
출원인 / 주소
The Johns Hopkins University
대리인 / 주소
Hayward, Noah J.
인용정보
피인용 횟수 :
0인용 특허 :
17
초록▼
Implantable pressure-actuated systems to deliver a drug and/or other substance in response to a pressure difference between a system cavity and an exterior environment, and methods of fabrication and use. A pressure-rupturable membrane diaphragm may be tuned to rupture at a desired rupture threshold
Implantable pressure-actuated systems to deliver a drug and/or other substance in response to a pressure difference between a system cavity and an exterior environment, and methods of fabrication and use. A pressure-rupturable membrane diaphragm may be tuned to rupture at a desired rupture threshold, rupture site, with a desired rupture pattern, and/or within a desired rupture time. Tuning may include material selection, thickness control, surface patterning, substrate support patterning. The cavity may be pressurized above or evacuated below the rupture threshold, and a diaphragm-protective layer may be provided to prevent premature rupture in an ambient environment and to dissipate within an implant environment. A drug delivery system may be implemented within a stent to release a substance upon a decrease in blood pressure. The cavity may include a thrombolytic drug to or other substance to treat a blood clot.
대표청구항▼
1. A method of using a pressure-actuated substance delivery system, wherein the pressure-actuated substance delivery system includes a substrate, a substance within a pressurized cavity of the substrate, a frangible layer disposed over a surface of the substrate, including over an opening to the cav
1. A method of using a pressure-actuated substance delivery system, wherein the pressure-actuated substance delivery system includes a substrate, a substance within a pressurized cavity of the substrate, a frangible layer disposed over a surface of the substrate, including over an opening to the cavity, and a substantially non-frangible layer of an implant-environment-dissipative material disposed over the frangible layer, wherein the frangible layer has a rupture threshold within a range of approximately 200 millimeters of mercury (mmHg) to 1200 mmHg, and a rupture time of at least 15 seconds and wherein the pressurized cavity is pressurized to a pressure that exceeds the rupture threshold by a rupture pressure within a range of approximately 20 mmHg to 50 mmHg relative to one atmosphere to cause the frangible layer to rupture when implant environment pressure falls below and remains below the rupture pressure for at least 15 seconds, the method comprising: introducing the pressure-actuated substance delivery system within an implant environment such that the substantially non-frangible layer contacts an implant environment fluid, wherein the substantially non-frangible layer is dissipated within the implant environment in response to contacting the implant environment fluid, and the frangible layer is exposed to the implant environment such that the frangible layer is exposed to the implant environment pressure in response to the substantially non-frangible layer being dissipated,wherein the frangible layer ruptures within the implant environment in response to a difference in pressure between the implant environment and the cavity that exceeds a rupture threshold of the frangible layer; andwherein the substance is released from the cavity into the implant environment through the opening in response to rupturing of the frangible layer. 2. The method of claim 1, wherein a stent containing the substance delivery system is received within a vascular implant environment, including one or more of a coronary blood vessel and a peripheral blood vessel. 3. The method of claim 1, wherein the substance includes a drug that includes at least one of a thrombolytic, a plasminogen, a plasmin, a heparin, an anti-thrombotic agent, an antiplatelet agent, an anti-inflammatory agent, an immunomodulator, an enzyme, a protein, DNA, RNA, mRNA, genetic material, virus particles, cells, small molecules, anti-lipid agent, or medication. 4. The method of claim 1, wherein the cavity houses one or more of a hydrogel and a sensory agent to invoke a sensory perception in a patient, and wherein release of the substance from the cavity into the implant environment through the opening in response to rupturing of the frangible layer includes one or more of: contacting an implant environment fluid with the hydrogel subsequent to rupturing of the frangible layer, and absorbing the implant environment fluid within the hydrogel to expand the hydrogel within the cavity; andreleasing the sensory agent into the implant environment through the opening subsequent to rupturing of the frangible layer. 5. The method of claim 1, wherein rupturing of the frangible layer is accomplished without external sensory or control intervention. 6. The method of claim 1, wherein rupturing of the frangible layer i-s-occurs in response to a change in implant environment pressure external to the frangible layer exceeding the rupture threshold. 7. The method of claim 6, wherein the change in implant environment pressure is a change in blood pressure. 8. A method of using a pressure-actuated drug delivery system, wherein the pressure-actuated drug delivery system includes a substrate, a drug within a pressurized cavity of the substrate, a frangible layer disposed over a surface of the substrate, including over an opening to the cavity, and a substantially non-frangible layer of an implant-environment-dissipative material disposed over the frangible layer, wherein the frangible layer has a rupture threshold within a range of approximately 200 millimeters of mercury (mmHg) to 1200 mmHg, and a rupture time of at least 15 seconds and wherein the pressurized cavity is pressurized to a pressure that exceeds the rupture threshold by a rupture pressure within a range of approximately 20 mmHg to 50 mmHg relative to one atmosphere to cause the frangible layer to rupture when implant environment pressure falls below and remains below the rupture pressure for at least 15 seconds, the method comprising: introducing the pressure-actuated drug delivery system within an implant environment such that the substantially non-frangible layer contacts an implant environment fluid, wherein the substantially non-frangible layer is dissipated within the implant environment in response to contacting the implant environment fluid, and the frangible layer is exposed to the implant environment such that the frangible layer is exposed to the implant environment pressure in response to the substantially non-frangible layer being dissipated,wherein the frangible layer ruptures within the implant environment in response to a difference in pressure between the implant environment and the cavity that exceeds a rupture threshold of the frangible layer; andwherein the drug is released from the cavity into the implant environment through the opening in response to rupturing of the frangible layer. 9. The method of claim 8, wherein a stent containing the drug delivery system is received within a vascular implant environment, including one or more of a coronary blood vessel and a peripheral blood vessel. 10. The method of claim 8, wherein the drug includes a thrombolytic drug. 11. The method of claim 8, wherein the cavity houses one or more of a hydrogel and a sensory agent to invoke a sensory perception in a patient, and wherein release of the drug from the cavity into the implant environment through the opening in response to rupturing of the frangible layer includes one or more of: contacting an implant environment fluid with the hydrogel subsequent to rupturing of the frangible layer, and absorbing the implant environment fluid within the hydrogel to expand the hydrogel within the cavity; andreleasing the sensory agent into the implant environment through the opening subsequent to rupturing of the frangible layer. 12. The method of claim 8, wherein rupturing of the frangible layer is accomplished without external sensory or control intervention. 13. The method of claim 8, wherein rupturing of the frangible layer i-s occurs in response to a change in implant environment pressure external to the frangible layer exceeding the rupture threshold. 14. The method of claim 13, wherein the change in implant environment pressure is a change in blood pressure.
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