Methods of using regenerative cells in the treatment of stroke and related diseases and disorders
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-035/12
A61K-035/28
C12N-005/0775
C12N-005/071
A61K-035/36
A61K-035/44
A61K-038/18
A61K-045/06
출원번호
US-0586735
(2012-08-15)
등록번호
US-9511094
(2016-12-06)
발명자
/ 주소
Fraser, John K.
Hedrick, Marc H.
Strem, Brian M.
출원인 / 주소
Cytori Therapeutics, Inc.
대리인 / 주소
Knobbe Martens Olson & Bear LLP
인용정보
피인용 횟수 :
1인용 특허 :
116
초록▼
Cells present in adipose tissue are used to stroke and stroke related diseases and disorders in a patient. Methods of treating patients include processing adipose tissue to deliver a concentrated amount of regenerative cells obtained from the adipose tissue to a patient. The methods may be practiced
Cells present in adipose tissue are used to stroke and stroke related diseases and disorders in a patient. Methods of treating patients include processing adipose tissue to deliver a concentrated amount of regenerative cells obtained from the adipose tissue to a patient. The methods may be practiced in a closed system so that the regenerative cells are not exposed to an external environment prior to being administered to a patient. Accordingly, in a preferred method, cells present in adipose tissue are placed directly into a recipient along with such additives necessary to promote, engender or support a therapeutic benefit.
대표청구항▼
1. A method of alleviating at least one adverse effect of stroke in a patient in need of an increased blood flow to an ischemic region comprising: identifying a patient in need of an increased blood flow to an ischemic region, wherein said patient has at least one symptom of stroke; andproviding to
1. A method of alleviating at least one adverse effect of stroke in a patient in need of an increased blood flow to an ischemic region comprising: identifying a patient in need of an increased blood flow to an ischemic region, wherein said patient has at least one symptom of stroke; andproviding to said patient an amount of an autologous, concentrated, heterogeneous population of cells comprising adipose-derived stem cells and progenitor cells sufficient to increase blood flow to said ischemic region and alleviate said symptom of stroke wherein said concentrated, heterogeneous population of cells comprising adipose-derived stem cells and progenitor cells has not been cultured. 2. The method of claim 1, wherein the autologous, concentrated, heterogeneous population of cells comprising adipose-derived stem cells is provided by intravenous infusion. 3. The method of claim 1, wherein the autologous, concentrated, heterogeneous population of cells comprising adipose-derived stem cells provided is within a range of about 1×105 cells/ml to about 1×107 cells/ml. 4. The method of claim 1, further comprising performing a neurologic examination of said patient. 5. The method of claim 1, further comprising performing an MRI on said patient. 6. The method of claim 1, further comprising performing doppler imaging on said patient. 7. The method of claim 1, wherein said stroke is an ischemic stroke. 8. The method of claim 1, wherein said autologous concentrated, heterogeneous population of cells comprising adipose-derived stem cells and progenitor cells further comprises an additive selected from the group consisting of bFGF, HGF, IL-6, and IL-13. 9. The method of claim 1, wherein said autologous concentrated, heterogeneous population of cells comprising adipose-derived stem cells and progenitor cells further comprises a cellular re-aggregation inhibitor or a disaggregation agent. 10. The method of claim 1, wherein the autologous concentrated, heterogeneous population of cells comprising adipose-derived stem cells and progenitor cells are provided via a subcutaneous, intra-carotid artery, intra-arterial, intrathecal or intra-parenchymal delivery route. 11. The method of claim 1, wherein the autologous, concentrated, heterogeneous population of cells comprising adipose-derived stem cells and progenitor cells are administered in a bolus. 12. The method of claim 1, wherein the autologous, concentrated, heterogeneous population of cells comprising adipose-derived stem cells and progenitor cells are administered in multiple doses. 13. The method of claim 1, wherein the autologous, concentrated, heterogeneous population of cells comprising adipose-derived stem cells and progenitor cells are separated from mature adipocytes and connective tissue. 14. The method of claim 1, wherein the autologous, concentrated, heterogeneous population of cells comprising adipose-derived stem cells and progenitor cells further comprises a neurogenic factor. 15. The method of claim 1, wherein the autologous, concentrated, heterogeneous population of cells comprising adipose-derived stem cells and progenitor cells is cryopreserved.
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