Pore structures for reduced pressure aerosolization
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
B05B-001/08
A61M-015/00
출원번호
US-0157134
(2014-01-16)
등록번호
US-9511199
(2016-12-06)
발명자
/ 주소
Patel, Rajesh S.
Srinivasan, Sudarsan
출원인 / 주소
Aradigm Corporation
대리인 / 주소
Borden, Paula A.
인용정보
피인용 횟수 :
0인용 특허 :
29
초록▼
A nozzle comprising a thin, flexible substantially planar polymeric film having a plurality of pores with structures allowing for generation of an aerosol at reduced extrusion pressure is disclosed. The pores can comprise at least two sections, or steps, in which the thickness of the membrane is red
A nozzle comprising a thin, flexible substantially planar polymeric film having a plurality of pores with structures allowing for generation of an aerosol at reduced extrusion pressure is disclosed. The pores can comprise at least two sections, or steps, in which the thickness of the membrane is reduced in stepwise fashion, or the pores can be tapered. Nozzles formed comprising pores having such structures permit aerosol generation at lower extrusion pressures, thereby allowing for decreased weight of aerosolization devices, increased efficiency, increased portability and increased battery life. The pore structures also allow for the use of thicker, more easily processed polymeric films in manufacturing while having a thinner, more efficient aerosolization area. The use of decreased extrusion pressures also results in increased uniformity in aerosol generation and improved reliability of other components.
대표청구항▼
1. An aerosol delivery device, comprising a) a sheet, said sheet having a plurality of pores, wherein each of said pores has an entrance aperture size and an exit aperture size, and wherein the ratio of said entrance aperture size to said exit aperture size is at least about 10:1; andb) a container
1. An aerosol delivery device, comprising a) a sheet, said sheet having a plurality of pores, wherein each of said pores has an entrance aperture size and an exit aperture size, and wherein the ratio of said entrance aperture size to said exit aperture size is at least about 10:1; andb) a container with a flowable liquid formulation, wherein said sheet has an entrance side to which said formulation is applied. 2. The device of claim 1, wherein the amount of liquid formulation in the container is from about 10 microliters to about 100 milliliters. 3. The device of claim 2, wherein the amount of liquid is from about 10 milliliters to about 90 milliliters. 4. The device of claim 2, wherein the amount of liquid is from about 20 microliters to about 100 microliters. 5. The device of claim 1, wherein the sheet is rigid. 6. The device of claim 1, wherein the sheet is a flexible membrane. 7. The device of claim 1, wherein the container is refillable. 8. The device of claim 1, wherein the container is disposable. 9. The device of claim 1, wherein the formulation is applied to the entrance side of the sheet by the application of a force to at least one wall of the container. 10. The device of claim 9, wherein the force leads to a pressure inside the container of less than about 725 psi. 11. The device of claim 1, wherein there is a low resistance filter positioned between the sheet and the container. 12. The device of claim 11, wherein the filter has a porosity such that the presence of the filter does not substantially increase the pressure required to generate an aerosol. 13. The device of claim 1, wherein the exit apertures of the pores are surrounded by elevated areas. 14. The device of claim 1, wherein the container includes an opening which leads to an open channel which channel includes a peelable seal which is peeled open upon the application of a force which is created by formulation being forced from the container. 15. A method of delivery of a drug to a patient, comprising: inhaling from the device of claim 1.
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이 특허에 인용된 특허 (29)
Carter Robert E. (Auburndale MA) Murphy Donald R. (Wellesley MA), Aerosol dispenser.
Lloyd Lester J. (Orinda CA) Lloyd Peter M. (Oakland CA) Rubsamen Reid M. (Berkeley CA), Disposable package for intrapulmonary delivery of aerosolized formulations.
Eichelberger Charles W. (Schenectady NY) Wojnarowski Robert J. (Ballston Lake NY) Welles ; II Kenneth B. (Scotia NY), Laser beam scanning method for forming via holes in polymer materials.
Nakayama Tetsuo,JPX ; Kishima Koichiro,JPX ; Ando Makoto,JPX ; Murakami Takaaki,JPX, Method for forming a hole and method for forming nozzle in orifice plate of printing head.
Asakawa Stuart D. (San Diego CA) McClelland Paul H. (Monmouth OR) Tappon Ellen R. (Corvallis OR) Vandepoll Richard R. (Vancouver WA) Trueba Kenneth E. (Corvallis OR) Chen Chien-Hua (Corvallis OR), Method for forming tapered inkjet nozzles.
Patel, Rajesh S.; Srinivasan, Sudarsan; Pon, Russell M.; Schuster, Jeffrey A.; Gonda, Igor, Method of fabricating porous membrane with unique pore structure for aerosolized delivery of drugs.
Rubsamen Reid ; Gonda Igor ; Farr Stephen ; Cipolla David, Prefilter for prevention of clogging of a nozzle in the generation of an aerosol and prevention of administration of und.
Patel Rajesh S. ; Srinivasan Sudarsan, Reactive ion etching method of fabricating nozzles for aerosolized delivery of therapeutic or diagnostic agents.
Lloyd Lester J. (Orinda CA) Lloyd Peter M. (Oakland CA) Rubsamen Reid M. (Berkeley CA) Schuster Jeffrey A. (Berkeley CA), Systems for the intrapulmonary delivery of aerosolized aqueous formulations.
Lloyd Lester John (Orinda CA) Lloyd Peter M. (Oakland CA) Rubsamen Reid M. (Berkeley CA) Schuster Jeffrey Arthur (Berkeley CA), Systems for the intrapulmonary delivery of aerosolized aqueous formulations.
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