Conversion of nitrogen dioxide (NO2) to nitric oxide (NO)
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61M-016/12
A61M-016/10
C01B-021/24
A61D-007/04
A61M-016/00
A61M-015/00
출원번호
US-0107629
(2013-12-16)
등록번호
US-9522249
(2016-12-20)
발명자
/ 주소
Rounbehler, David P.
Fine, David H.
출원인 / 주소
GENO LLC
대리인 / 주소
Steptoe & Johnson LLP
인용정보
피인용 횟수 :
0인용 특허 :
56
초록▼
Inhalation of low levels of nitric oxide can rapidly and safely decrease pulmonary hypertension in mammals. A nitric oxide delivery system that converts nitrogen dioxide to nitric oxide employs a surface-active material, such as silica gel, coated with an aqueous solution of antioxidant, such as asc
Inhalation of low levels of nitric oxide can rapidly and safely decrease pulmonary hypertension in mammals. A nitric oxide delivery system that converts nitrogen dioxide to nitric oxide employs a surface-active material, such as silica gel, coated with an aqueous solution of antioxidant, such as ascorbic acid.
대표청구항▼
1. An apparatus for converting nitrogen dioxide to nitric oxide suitable for delivery to a human comprising a receptacle including an inlet a cartridge comprising a permeable support comprising vitamin C or Vitamin E, and an outlet, and wherein the inlet is configured to receive a gas flow comprisin
1. An apparatus for converting nitrogen dioxide to nitric oxide suitable for delivery to a human comprising a receptacle including an inlet a cartridge comprising a permeable support comprising vitamin C or Vitamin E, and an outlet, and wherein the inlet is configured to receive a gas flow comprising nitrogen dioxide and fluidly communicate the gas flow through the receptacle to the outlet, such that the gas flow contacts the vitamin inside the receptacle, and the vitamin converts substantially all of the nitrogen dioxide in the gas flow to nitric oxide. 2. The apparatus of claim 1, wherein the permeable support comprises a substrate that retains water. 3. The apparatus of claim 1, wherein the permeable support comprises a silica gel. 4. The apparatus of claim 1, wherein the vitamin includes ascorbic acid, alpha tocopherol or gamma tocopherol. 5. An apparatus for generating a therapeutic gas including nitric oxide comprising: a permeation cell having liquid nitrogen dioxide and capable of diffusing gaseous nitrogen dioxide into a gas flow; anda receptacle including an inlet, an outlet and disposed within said receptacle a vitamin C or vitamin E, wherein the inlet is configured to receive the gas flow comprising nitrogen dioxide and fluidly communicate the gas flow through the receptacle to the outlet, such that the gas flow contacts the vitamin inside the receptacle, and the vitamin converts substantially all of the nitrogen dioxide in the gas flow to nitric oxide, thereby generating a therapeutic gas including nitric oxide. 6. The apparatus of claim 5, wherein the receptacle is a first receptacle, the apparatus further comprising a second receptacle including a second inlet, a second outlet and a second vitamin, wherein the second inlet is configured to receive the gas flow comprising nitrogen dioxide and fluidly communicate the gas flow through the receptacle to the second outlet, such that the gas flow contacts the second vitamin inside the second receptacle, and the second vitamin converts substantially all of the nitrogen dioxide in the gas flow to nitric oxide. 7. The apparatus of claim 6, wherein the vitamin in the first receptacle and the second vitamin are the same. 8. The apparatus of claim 5, wherein the receptacle further comprises a permeable support for the vitamin. 9. The apparatus of claim 8, wherein the permeable support for the vitamin comprises a substrate that retains water. 10. The apparatus of claim 9, wherein the permeable support for the vitamin comprises a silica gel. 11. The apparatus of claim 6, wherein the second receptacle further comprises a permeable support for the second vitamin. 12. The apparatus of claim 11, wherein the permeable support for the vitamin in the first receptacle and the permeable support for the second vitamin are the same. 13. The apparatus of claim 5, further comprising an air pump capable of generating the gas flow, wherein the permeation cell is configured to receive the gas flow generated by the air pump. 14. The apparatus of claim 13, wherein the air pump is portable. 15. The apparatus of claim 5, further comprising an oxygen-enrichment device capable of supplying oxygen in the gas flow, wherein the permeation cell is configured to receive the gas flow enriched by the oxygen-enrichment device. 16. The apparatus of claim 5, wherein the vitamin comprises ascorbic acid, alpha tocopherol or gamma tocopherol. 17. The apparatus of claim 6, further comprising a flexible bag operable to inflate and deflate as a mammal receiving the therapeutic gas breathes, and wherein the second receptacle is positioned between the flexible bag and a point at which the therapeutic gas flow including nitric oxide is delivered to the mammal.
Bullens Valere G. J. (Eindhoven NLX) Pauw Hermanus (Eindhoven NLX) Falkenburg Rudy A. (Eindhoven NLX), Device for the quantitative reduction of nitrogen dioxide in gas mixtures.
Olsson Sven-Gunnar (Arloev SEX) Rydgren Goeran (Bunkeflostrand SEX) Larsson Anders (Kaevlinge SEX) Brauer Stefan (Sodra Sandby SEX) Linge Anders (Kaevlinge SEX), Gas mixture and device for delivering the gas mixture to the lungs of a respiratory subject.
Keefer Larry K. (Bethesda MD) Hrabie Joseph A. (Frederick MD), Implants, prostheses, and stents comprising polymer-bound nitric oxide/nucleophile adducts capable of releasing nitric o.
Loscalzo, Joseph; Vita, Joseph A.; Loberg, Michael D.; Worcel, Manuel, Methods of treating vascular diseases characterized by nitric oxide insufficiency.
Bathe Duncan P. L. (Madison WI) Kohlmann Thomas S. (McFarland WI) Pinkert John R. (Madison WI) Tham Robert Q. (Middleton WI), Nitric oxide delivery system.
Fitzhugh Anthony L. ; Cheng Peiwen ; Saavedra Joseph ; Cafferata Robert ; Hendriks Marc,NLX ; Keefer Larry K. ; Tedeschi Eugene ; Verhoeven Michel L. P. M.,NLX, Nitric oxide-releasing metallic medical devices.
Keefer Larry K. (Bethesda MD) Hrabie Joseph A. (Frederick MD) Saavedra Joseph E. (Thurmont MD), Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions incorporating same and methods o.
Sheu Lien-Lung (Scotch Plains NJ) Ramachandran Ramakrishnan (Allendale NJ) Galica Theodore R. (Glen Gardner NJ), Process for the purification of nitric oxide.
Kleiner,Bela, Reverse Kleiner method for manufacturing nitrogen dioxide, nitric oxide, nitric acid, metallic ascorbates and alkyl ascorbates of vitamin C.
Arnold, Ernst V.; Doletski, Blaine G.; Dunn, Thomas M.; Raulli, Robert E.; Mueller, Edward P.; Benedek, Karen R.; Murville, Marie-Louise, Sterilization system and device.
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