According to an aspect of the invention, injectable polymeric particles are provided that contain a copolymer that contains a hydroxy-acid-based repeat unit selected from a mono(hydroxy acid) unit and a poly(hydroxy acid) unit, an alkyl-ether-based repeat unit selected from a mono(alkyl ether) unit
According to an aspect of the invention, injectable polymeric particles are provided that contain a copolymer that contains a hydroxy-acid-based repeat unit selected from a mono(hydroxy acid) unit and a poly(hydroxy acid) unit, an alkyl-ether-based repeat unit selected from a mono(alkyl ether) unit and a poly(alkyl ether) unit, and an acid-based repeat unit selected from a unit comprising multiple carboxylic acid groups and a derivative thereof. Other aspects of the invention pertain to methods of making such particles. Still other aspects of the invention pertain to injectable compositions that comprise such particles and to methods of treatment that employ such injectable compositions.
대표청구항▼
1. Injectable polymeric particles comprising a copolymer that comprises (a) a hydroxy-acid-based repeat unit selected from a mono(hydroxy acid) unit and a poly(hydroxy acid) unit,(b) an alkyl-ether-based repeat unit selected from a mono(alkyl ether) unit and a poly(alkyl ether) unit, and(c) an acid-
1. Injectable polymeric particles comprising a copolymer that comprises (a) a hydroxy-acid-based repeat unit selected from a mono(hydroxy acid) unit and a poly(hydroxy acid) unit,(b) an alkyl-ether-based repeat unit selected from a mono(alkyl ether) unit and a poly(alkyl ether) unit, and(c) an acid-based repeat unit selected from a unit comprising multiple carboxylic acid groups, a unit comprising multiple acid chloride groups, and a cyclic acid anhydride unit, wherein 95 vol % of the particles have a longest linear cross-sectional dimension between 40 μm and 5000 μm. 2. The injectable polymeric particles of claim 1, wherein said alkyl-ether-based repeat unit comprises one or more alkyl ether monomers selected from ethylene oxide, propylene oxide and butylene oxide. 3. The injectable polymeric particles of claim 1, wherein said alkyl-ether-based repeat unit is of the formula R1—On, where in the preceding formula R1 is C1-C10 linear or branched alkyl and n is an integer of 1 or more. 4. The injectable polymeric particles of claim 1, wherein said hydroxy-acid-based repeat unit comprises one or more hydroxy acid monomers selected from branched and unbranched C1-C10 hydroxy acids. 5. The injectable polymeric particles of claim 1, wherein said hydroxy-acid-based repeat unit comprises one or more hydroxy acid monomers selected from glycolic acid and lactic acid. 6. The injectable polymeric particles of claim 1, wherein said hydroxy-acid-based repeat unit is of the formula, where in the preceding formula R2 is H or C1-C10 linear or branched alkyl and n is an integer of 1 or more. 7. The injectable polymeric particles of claim 1, wherein said acid-based repeat unit is selected from dicarboxylic acids, tricarboxylic acids, dicarboxylic acid chlorides, tricarboxylic acid chlorides, and cyclic acid anhydrides. 8. The injectable polymeric particles of claim 1, wherein said acid-based repeat unit is of the formula, where in the preceding formula n is one and R3 is selected from (a) a bond and (b) C1-C10 linear or branched alkyl, which may be either unsubstituted or substituted with one or more halogen atoms. 9. The injectable polymeric particles of claim 8, wherein said one or more halogen atoms comprise bromine atoms, iodine atoms, or a combination thereof. 10. The injectable polymeric particles of claim 1, wherein said particles do not contain an ionic or covalent cross-linking agent. 11. The injectable polymeric particles of claim 1, wherein said copolymer further comprises bromine atoms, iodine atoms or a combination thereof. 12. The injectable polymeric particles of claim 1, wherein said injectable particles are spherical. 13. The injectable polymeric particles of claim 1, wherein said particles are porous particles. 14. The injectable polymeric particles of claim 1, wherein 95 vol % of said particles have a longest linear cross-sectional dimension between 100 and 1200 μm. 15. The injectable polymeric particles of claim 1, wherein said copolymer further comprises a group that chelates a charged radioisotope. 16. The injectable polymeric particles of claim 1, further comprising a therapeutic agent selected from toxins, thrombogenic agents, antineoplastic agents, ablation agents, proinflammatory agents and sclerosing agents. 17. The injectable polymeric particles of claim 1, further comprising a therapeutic agent that non-covalently binds to the particles by electrostatic interactions with binding groups in the particles. 18. The injectable polymeric particles of claim 17, wherein said therapeutic agent is a charged radioisotope and said particles comprise ligands that form coordination complexes with the charged radioisotope. 19. The injectable particles of claim 1, wherein said hydroxy-acid-based repeat unit:alkyl-ether-based repeat unit:acid-based repeat unit ratio is 1:1:1. 20. The injectable particles of claim 1, wherein said hydroxy-acid-based repeat unit:alkyl-ether-based repeat unit:acid-based repeat unit ratio is 2:1:1. 21. An injectable medical composition comprising the particles of claim 1. 22. The injectable medical composition of claim 21, comprising a tonicity adjusting agent. 23. The injectable medical composition of claim 21, wherein said injectable medical composition is disposed within a glass container or a preloaded medical device. 24. A method of embolization comprising injecting the injectable medical composition of claim 21 into a patient. 25. A method of tissue bulking comprising injecting the injectable medical composition of claim 21 into a patient.
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이 특허에 인용된 특허 (5)
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