초록

Cross-linked peptides related to human p53 and bind to HMD2 or a family member of HDM2 useful for promoting apoptosis, e.g., in the treatment of and identifying therapeutic agents that binding to HMD2 or a family member of HDM2.

대표청구항 ▼

1. A peptide of Formula (I), or a pharmaceutically acceptable salt thereof, wherein: each R1 and R2 is independently H, alkyl, alkenyl, alkynyl, arylalkyl, cycloalkylalkyl, heteroarylalkyl, or heterocyclylalkyl;each R3 is independently alkyl, alkenyl, alkynyl, or [R4—K—R4′]n, each of which is indep

1. A peptide of Formula (I), or a pharmaceutically acceptable salt thereof, wherein: each R1 and R2 is independently H, alkyl, alkenyl, alkynyl, arylalkyl, cycloalkylalkyl, heteroarylalkyl, or heterocyclylalkyl;each R3 is independently alkyl, alkenyl, alkynyl, or [R4—K—R4′]n, each of which is independently substituted with 0-6 R5;each R4 and R4′ is independently alkylene, alkenylene or alkynylene;each R5 is independently halo, alkyl, OR6, N(R6)2, SR6, SOR6, SO2R6, CO2R6, R6, a fluorescent moiety, or a radioisotope;each K is independently O, S, SO, SO2, CO, CO2, CONR6, or each R6 is independently H, alkyl, or a therapeutic agent;each n is independently an integer from 1-4;each x is 6;each y is independently an integer from 0-100;each w is independently an integer from 0-100;z is an integer from 1-10; andeach Xaa is independently an amino acid;wherein the peptide comprises 8 contiguous amino acid residues, wherein the 8 contiguous amino acid residues comprise Phe, Leu, and Trp, wherein the peptide exhibits a binding affinity for HDM2 that is from about 0.75 nM to about 110 nM, wherein [Xaa]x prises the Leu and the Trp. 2. The peptide of claim 1, wherein the peptide binds to HDM2. 3. The peptide of claim 1, wherein each R3 is independently an alkenylene group. 4. The peptide of claim 1, wherein each R3 is independently an alkylene group. 5. The peptide of claim 1, wherein each R1 and each R2 is independently alkyl. 6. The peptide of claim 1, wherein each R1 and each R2 is methyl. 7. The peptide of claim 1, wherein each R1 and each R2 is H. 8. The peptide of claim 1, wherein z is 1. 9. The peptide of claim 1, wherein each w is independently an integer from 3 to 15. 10. The peptide of claim 1, wherein each y is independently an integer from 3 to 15. 11. The peptide of claim 1, wherein the peptide is permeable to a cell membrane. 12. The peptide of claim 1, wherein the peptide comprises a helix. 13. The peptide of claim 1, wherein the peptide comprises an α-helix. 14. The peptide of claim 13, wherein R3 extends across the length of one helical turn. 15. The peptide of claim 13, wherein R3 extends across the length of two helical turns.