A modified starch material for biocompatible hemostasis, biocompatible adhesion prevention, tissue healing promotion, absorbable surgical wound sealing and tissue bonding, when applied as a biocompatible modified starch to the tissue of animals. The modified starch material produces hemostasis, redu
A modified starch material for biocompatible hemostasis, biocompatible adhesion prevention, tissue healing promotion, absorbable surgical wound sealing and tissue bonding, when applied as a biocompatible modified starch to the tissue of animals. The modified starch material produces hemostasis, reduces bleeding of the wound, extravasation of blood and tissue exudation, preserves the wound surface or the wound in relative wetness or dryness, inhibits the growth of bacteria and inflammatory response, minimizes tissue inflammation, and relieves patient pain. Any excess modified starch not involved in hemostatic activity is readily dissolved and rinsed away through saline irrigation during operation. After treatment of surgical wounds, combat wounds, trauma and emergency wounds, the modified starch hemostatic material is rapidly absorbed by the body without the complications associated with gauze and bandage removal.
대표청구항▼
1. A method of reducing adhesion between a wounded tissue and an other tissue of an animal, comprising: applying, directly onto the wounded tissue of the animal, a powder consisting essentially of biocompatible modified starch particles that are non-porous, characterized in that the non-porous modif
1. A method of reducing adhesion between a wounded tissue and an other tissue of an animal, comprising: applying, directly onto the wounded tissue of the animal, a powder consisting essentially of biocompatible modified starch particles that are non-porous, characterized in that the non-porous modified starch particles are substantially devoid of a microporous surface, and optionally an antibiotic, such that the applied powder forms an adhesion barrier in form of a matrix on said wounded tissue, thereby reducing adhesion between the wounded tissue and the other tissue. 2. The method of claim 1, wherein the biocompatible modified starch particles have a grain diameter of 1 to 1000 μm. 3. The method of claim 1, wherein the biocompatible modified starch particles have a molecular weight of 15,000 daltons or more. 4. The method of claim 1, wherein the biocompatible modified starch particles exhibit water absorbency capacity of at least 1 times its own weight. 5. The method of claim 1, wherein the biocompatible modified starch particles exhibit water absorbency capacity of 2-500 times its own weight. 6. The method of claim 1, wherein the biocompatible modified starch particles exhibit a viscosity of a 6.67% water suspension not lower than 30 mPas at 37° C. 7. The method of claim 1, wherein the biocompatible modified starch particles exhibit an adhesion Work Index at maximum water absorption at room temperature exceeding 40 g·sec (100% saturation) when assayed with a texture analyzer (Stable Micro System, Model TA-XT plus) together with a backforward extrusion probe (A/BE) or a cylindrical probe (P36R). 8. The method of claim 1, wherein the step of applying comprises spraying the powder directly onto the wounded tissue. 9. The method of claim 1, wherein the powder applied is in an aerosol form. 10. The method of claim 1, wherein the biocompatible modified starch particles are etherified starch or esterified starch. 11. The method of claim 10, wherein the biocompatible modified starch particles are carboxymethyl starch. 12. The method of claim 11, wherein the carboxymethyl starch is carboxymethyl Sodium. 13. The method of claim 10, wherein the biocompatible modified starch particles are hydroxyethyl starch. 14. The method of claim 10, wherein the biocompatible modified starch particles are carboxyethyl starch. 15. The method of claim 1, wherein the biocompatible modified starch particles are pre-gelatinized modified starch. 16. The method of claim 1, wherein the biocompatible modified starch particles are cross-linked starch. 17. The method of claim 1, wherein the biocompatible modified starch particles are uncross-linked starch. 18. The method of claim 1, wherein the biocompatible modified starch particles are composite modified starch. 19. The method of claim 1, wherein the biocompatible modified starch particles contain a modified glucose unit having the formula of: 20. The method of claim 19, wherein the modified starch contains a hydrophilic group selected from the group consisting of carboxyethyl, carboxymethyl, hydroxyethyl, and hydroxymethyl. 21. The method of claim 19, wherein the modified starch dissolves or swells in water and forms adhesive gel or adhesive liquid. 22. The method of claim 1, wherein the powder is mixed with one or more of biocompatible carboxymethyl cellulose, chitosan, sodium alginate, and coagulant. 23. The method of claim 1, wherein the biocompatible modified starch particles are agglomerated particles. 24. The method of claim 1, wherein the biocompatible modified starch particles are non-agglomerated particles. 25. The method of claim 1, wherein the step of applying is performed under a surgery. 26. The method of claim 25, wherein the surgery is open surgery, or minimally invasive surgery selected from the group consisting of celioscopy, nasoscopy, laryngoscopy, endoscopy, and laparoscopy. 27. The method of claim 1, wherein the animal is a human. 28. The method of claim 1, wherein the adhesion barrier is biodegradable. 29. The method of claim 1, wherein the adhesion barrier degrades after 24 hours. 30. The method of claim 1, wherein the adhesion barrier is degradable by amylase.
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