Apparatuses and methods for administering a hemostatic agent to the tissue surrounding an opening in a body lumen are disclosed. The apparatus can include a tissue-contacting region and an optional body lumen-penetrating region. At least one hemostatic agent is included as a component of a coating o
Apparatuses and methods for administering a hemostatic agent to the tissue surrounding an opening in a body lumen are disclosed. The apparatus can include a tissue-contacting region and an optional body lumen-penetrating region. At least one hemostatic agent is included as a component of a coating over and/or a mixture with the material of at least a portion of the tissue-contacting region.
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1. An apparatus for administration of at least one hemostatic agent to a tissue surrounding an opening in a wall of a body lumen, the apparatus comprising: an elongate element that includes a proximal end, an open distal end, a lumen extending therebetween, and an outer surface having a tissue conta
1. An apparatus for administration of at least one hemostatic agent to a tissue surrounding an opening in a wall of a body lumen, the apparatus comprising: an elongate element that includes a proximal end, an open distal end, a lumen extending therebetween, and an outer surface having a tissue contacting region and a body lumen-penetrating region; andat least one hemostatic agent disposed on the tissue-contacting region, anda depth indicia configured to designate the tissue-contacting region, the depth indicia includes a first color on the tissue-contacting region and a second color on the body lumen-penetrating region. 2. The apparatus as recited in claim 1, wherein the tissue-contacting region includes at least a portion of the elongate element that is capable of contacting non-vascular tissues surrounding a venous or arterial puncture site without being inserted into or contacting an inside portion of the vein or artery. 3. The apparatus as recited in claim 1, the at least one hemostatic agent is included as a component of a coating over and/or a mixture with a material that defines the tissue-contacting region. 4. An apparatus for administration of at least one hemostatic agent to a tissue surrounding an opening in a wall of a body lumen, the apparatus comprising: an elongate element that includes a tissue-contacting region, a body lumen-penetrating region, a proximal end, a distal end, and a lumen extending therebetween;at least one hemostatic agent disposed on the tissue-contacting region, the body lumen-penetrating region being substantially devoid of the hemostatic agent; anda depth indicia positioned on the elongate element, the depth indicia being configured to designate the tissue-contacting region, wherein the depth indicia includes a first color on the tissue-contacting region and a second color on the body lumen-penetrating region. 5. The apparatus as recited in claim 4, wherein the depth indicia includes at least one radiopaque band. 6. The apparatus as recited in claim 4, wherein the body lumen-penetrating region includes at least a portion of the elongate, substantially cylindrical element that is capable of being inserted into or contacting an inside portion of a vein or artery. 7. The apparatus as recited in claim 6, wherein the body lumen-penetrating region includes a length that is at least partially defined by a diameter of the inside portion of the vein or artery. 8. The apparatus as recited in claim 4, wherein the at least one hemostatic agent is selected from a group consisting of aminocaproic acid, prothrombin, thrombin, thromboxane A2, thromboxane B2, an endothelin, a vasoconstrictor, an adrenergic agent, an angiotensin, lysine, polylysine, tranexamic acid, N-acetyl-lysine-methyl ester, bentonite, collagen, chitosan, cationic polymers, viscosity increasing polymers, anti-fibrinolytic proteins, coagulation catalyzing compounds, coagulation factors, or crosslinkers, derivatives thereof, pharmaceutically acceptable salts thereof, and combinations thereof. 9. An apparatus for administration of at least one hemostatic agent to a tissue surrounding an opening in a wall of a body lumen, the apparatus comprising: an elongate element that includes a tissue-contacting region, a proximal end, a distal end, and a lumen extending therebetween;a depth indicia positioned on the elongate element, the depth indicia being configured to designate the tissue-contacting region, the depth indicia includes a first color on the tissue-contacting region and a second color on the body lumen-penetrating region; andat least one hemostatic agent disposed on the tissue-contacting region, the at least one hemostatic agent being selected from a group including aminocaproic acid, prothrombin, thrombin, thromboxane A2, thromboxane B2, an endothelin, a vasoconstrictor, an adrenergic agent, an angiotensin, lysine, polylysine, tranexamic acid, N-acetyl-lysine-methyl ester, bentonite, collagen, chitosan, cationic polymers, viscosity increasing polymers, anti-fibrinolytic proteins, coagulation catalyzing compounds, coagulation factors, or crosslinkers, derivatives thereof, pharmaceutically acceptable salts thereof, and combinations thereof. 10. The apparatus as recited in claim 9, wherein the at least one hemostatic agent is included as a component of a coating over and/or a mixture with a material that defines the tissue-contacting region. 11. The apparatus as recited in claim 9, wherein the body lumen-penetrating region is substantially devoid of hemostatic agent. 12. The apparatus as recited in claim 9, wherein the depth indicia includes at least one radiopaque band.
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