Personalizing substance for application to the skin or addition to tattoo ink and methods of preparation thereof
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-008/11
A61K-008/60
A61K-008/81
A61Q-001/02
A61K-008/02
출원번호
US-0016864
(2016-02-05)
등록번호
US-9539186
(2017-01-10)
발명자
/ 주소
Duffy, Patrick
Jorgensen, Ellen Dias
Boger, Erich
Mathiowitz, Edith
출원인 / 주소
Chamber Works, LLC
대리인 / 주소
McCarter & English, LLP
인용정보
피인용 횟수 :
0인용 특허 :
8
초록▼
Compositions for delivering materials, such as a biological material, sand, soil, metal, water, sea water, holy water, synthetic or biological polymers, cremated ash, ceramics, animal or plant tissue, or another physiologically compatible component having personal significance to an individual are d
Compositions for delivering materials, such as a biological material, sand, soil, metal, water, sea water, holy water, synthetic or biological polymers, cremated ash, ceramics, animal or plant tissue, or another physiologically compatible component having personal significance to an individual are described herein. The material(s) are encapsulated in an inert, non-bioerodible, hydrophobic, polymeric material. Methods of making microparticles encapsulating the personalizing substance and methods of use are also provided. The personalizing substance may be encapsulated in a polymeric non-bioerodible microparticle. The encapsulated personalizing substance may be combined with a carrier for delivery to an individual's skin. In some embodiments, the personalizing substance is added to a tattoo ink and incorporated in a tattoo created on an individual's skin. Following injection in the skin, the encapsulated material remains in the microparticles, and is not released over time.
대표청구항▼
1. A method of applying an ink tattoo to the skin of an individual comprising injecting into the individual's skin a composition comprising:(i) tattoo ink; and(ii) non-bioerodible microparticles comprising DNA encapsulated in a biocompatible, hydrophobic, non-bioerodible polymer, wherein(a) the micr
1. A method of applying an ink tattoo to the skin of an individual comprising injecting into the individual's skin a composition comprising:(i) tattoo ink; and(ii) non-bioerodible microparticles comprising DNA encapsulated in a biocompatible, hydrophobic, non-bioerodible polymer, wherein(a) the microparticles do not release a detectable amount of the DNA for at least one year after delivery to an individual's skin;(b) the DNA remains at the site of delivery; and(c) the microparticles comprise up to 0.01% (w/w) DNA. 2. The method of claim 1, wherein the injection is made at the site of an existing tattoo. 3. The method of claim 1, further comprising mixing the microparticles with the tattoo ink prior to injection. 4. The method of claim 1, wherein the step of injecting is repeated multiple times at different sites on the skin to form a tattoo design. 5. The method of claim 1, wherein the DNA is in the form of nanoparticles. 6. The method of claim 1, wherein the microparticles have a size ranging from 1 micron to 5 microns. 7. The method of claim 1, wherein the DNA comprises a personal identification characteristic selected from the group consisting of short tandem repeats (STRs), single nucleotide polymorphisms (SNPs), epigenetic markers, and methylated DNA. 8. The method of claim 1, wherein the polymer has a glass transition temperature that is greater than or equal to 60° C. or has a melting point greater than or equal to 50° C. 9. The method of claim 1, wherein the microparticles do not comprise visible pores using scanning electron microscopy (SEM). 10. The method of claim 1, wherein the microparticles do not comprise silica. 11. The method of claim 1, wherein the DNA is isolated from an organism. 12. The method of claim 11, wherein the organism is a human. 13. The method of claim 1, wherein the composition further comprises a carrier suitable for injection into the skin. 14. The method of claim 13, wherein the carrier is selected from the group consisting of ethyl alcohol, isopropyl alcohol, glycerol, and water. 15. The method of claim 13, wherein the carrier is a solution of 60% water, 30% glycerol, and 10% ethanol. 16. The method of claim 1, wherein the polymer is selected from the group consisting of polyvinyl acetate, polyacrylate, polymethacrylate, and copolymers and blends thereof.
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