Adhesive compositions and patches, and associated systems, kits, and methods, are generally described. Certain of the adhesive compositions and patches can be used to treat tissues (e.g., in hemostatic or other tissue treatment applications), according to certain embodiments.
대표청구항▼
1. A method of forming an adhesive matrix, comprising: establishing a mixture comprising a non-aqueous liquid, a first polyacrylic acid crosslinked with pentaerythritol and/or allyl sucrose, and a second polyacrylic acid crosslinked with divinyl glycol on a substrate, wherein the amount of water in
1. A method of forming an adhesive matrix, comprising: establishing a mixture comprising a non-aqueous liquid, a first polyacrylic acid crosslinked with pentaerythritol and/or allyl sucrose, and a second polyacrylic acid crosslinked with divinyl glycol on a substrate, wherein the amount of water in the mixture is less than or equal to about 2 wt. %;applying a non-aqueous polar solvent to the mixture on the substrate, wherein the non-aqueous polar solvent contains at least one of methanol, ethanol, propanol, and butanol; andallowing at least a portion of the non-aqueous liquid and the non-aqueous polar solvent to evaporate to produce the adhesive matrix,wherein, after the evaporation, the sum of the amount of the non-aqueous liquid and the non-aqueous polar solvent in the adhesive matrix is between about 0.001 wt % and about 3 wt %. 2. The method of claim 1, wherein the non-aqueous liquid is selected from the group consisting of ethyl acetate, tetrahydrofuran, diethyl ether, dioxane, pyridine, triethylamine, benzene, p-cresol, toluene, xylene, glycol, petroleum ether, hexane, cyclohexane, pentane, methylene chloride, chloroform, carbon tetrachloride, dimethyl sulfoxide, dimethylformamide, hexamethyl-phosphoric triamide, picoline, and mixtures thereof. 3. The method of claim 1, wherein the adhesive matrix is non-covalently cross-linked. 4. The method of claim 1, wherein the adhesive matrix is self-supporting. 5. The method of claim 1, wherein the first polyacrylic acid and the second polyacrylic acid are hydrogen bonded to one another in the adhesive matrix. 6. The method of claim 1, wherein the mixture further comprises a polyol or a non-ionic surfactant. 7. The method of claim 1, wherein the amount of the non-aqueous polar solvant in the adhesive matrix is between about 0.001 wt. % and 1 wt. %. 8. The method of claim 1, wherein the mixture contains less than or equal to about 0.1 wt. % water. 9. The method of claim 1, wherein the weight percentage of polyacrylic acid in the adhesive matrix is greater than or equal to about 90 wt. %. 10. The method of claim 1, wherein the substrate comprises small intestinal submucosa and/or fibrin. 11. The method of claim 1, wherein the adhesive matrix is a water-activated adhesive matrix. 12. The method of claim 1, wherein the establishing step comprises applying the mixture to the substrate. 13. A tissue adhesive composite, comprising: a tissue adhesive film positioned on at least a portion of a substrate,wherein the tissue adhesive film comprises: a first polyacrylic acid crosslinked with pentaerythritol and/or allyl sucrose;a second polyacrylic acid crosslinked with divinyl glycol; anda liquid comprising at least one of methanol, ethanol, propanol and butanol;wherein: greater than or equal to about 90 wt % of the tissue adhesive film is made up of polyacrylic acid, andless than about 8 wt % of the tissue adhesive film is made up of the liquid. 14. The tissue adhesive composite of claim 13, wherein the tissue adhesive film has a burst strength of at least about 100 mmHg gauge. 15. The tissue adhesive composite of claim 13, wherein the tissue adhesive film has a lap shear adhesive strength of at least about 1.5 pound force. 16. The tissue adhesive composite of claim 13, wherein the thickness of the tissue adhesive film does not vary by more than about 10% across its surface. 17. The tissue adhesive composite of claim 13, wherein an amount of water within the tissue adhesive film is less than or equal to about 0.1 wt. %. 18. The tissue adhesive composite of claim 13, wherein the substrate comprises a material selected from the group consisting of small intestinal submucosa, a fibrin-based substrate, diaphragm, porcine skin, bovine skin, human skin, pericardium, extracellular matrix collagen, and amnion. 19. The tissue adhesive composite of claim 13, wherein the weight percentage of polyacrylic acid in the tissue adhesive film is greater than or equal to about 95 wt %. 20. The tissue adhesive composite of claim 13, wherein the tissue adhesive film is a self-supporting layer. 21. The tissue adhesive composite of claim 13, wherein the first polyacrylic acid and the second polyacrylic acid are hydrogen bonded to one another in the tissue adhesive film. 22. The tissue adhesive composite of claim 13, wherein the liquid comprises ethanol. 23. The method of claim 1, wherein the non-aqueous polar solvent is made up of at least about 90 wt. % ethanol.
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이 특허에 인용된 특허 (136)
Blomback, Birger; Hessel, Birgit; Olsson, Per; Stromberg, Lennart; Swedenborg, Jesper; Stocker, Kurt, Adhesive for the gluing of biological tissues.
Juergensen Kay (Murten CHX) Aeschlimann Daniel (Basel CHX) Hunziker Ernst B. (Riedholz CHX), Biological adhesive composition and method of promoting adhesion between tissue surfaces.
Doggett Roger H. (Natick MA) Buccigross Henry L. (Needham MA), Bonding method employing water-activatable adhesive compositions comprising a plasticizer and an N-sulfohydrocarbon-subs.
Edwardson Peter A. D.,GBX ; Fairbrother John E.,GBX ; Gardner Ronald S.,GBX ; Hollingsbee Derek A.,GBX ; Cederholm-Williams Stewart A.,GBX, Compositions useful as fibrin sealants.
David B. Masters, Drug delivery devices comprising biodegradable protein for the controlled release of pharmacologically active agents and method of making the drug delivery devices.
Li Lehmann K. (Fairfield CT) Warren Russell F. (Greenwich CT) Arnoczky Steven P. (New York NY) Bedard Robert J. (Southbury CT), Fibrin clot delivery device and method.
Edwardson Peter A. D.,GBX ; Fairbrother John E.,GBX ; Gardner Ronald S.,GBX ; Hollingsbee Derek A.,GBX ; Cederholm-Williams Stewart A.,GBX, Fibrin sealant compositions.
Edwardson Peter A. D.,GBX ; Fairbrother John E.,GBX ; Gardner Ronald S.,GBX ; Hollingsbee Derek A.,GBX ; Cederholm-Williams Stewart A.,GBX, Fibrin sealant compositions and methods for utilizing same.
Edwardson Peter A. D.,GBX ; Fairbrother John E.,GBX ; Gardner Ronald S.,GBX ; Hollingsbee Derek A.,GBX ; Cederholm-Williams Stewart A.,GBX, Fibrin sealant compositions and methods for utilizing same.
Edwardson Peter A. D.,GBX ; Fairbrother John E.,GBX ; Gardner Ronald S.,GBX ; Hollingsbee Derek A.,GBX ; Cederholm-Williams Stewart A.,GBX, Fibrin sealant compositions and methods for utilizing same.
Edwardson Peter A. D.,GBX ; Fairbrother John E.,GBX ; Gardner Ronald S.,GBX ; Hollingsbee Derek A.,GBX ; Cederholm-Williams Stewart A.,GBX, Fibrin sealant compositions and methods for utilizing same.
Edwardson Peter A. D.,GBX ; Fairbrother John E.,GBX ; Gardner Ronald S.,GBX ; Hollingsbee Derek A.,GBX ; Cederholm-Williams Stewart A.,GBX, Fibrin sealant compositions and methods for utilizing same.
Edwardson Peter A. D.,GBX ; Fairbrother John E.,GBX ; Gardner Ronald S.,GBX ; Hollingsbee Derek A.,GBX ; Cederholm-Williams Stewart A.,GBX, Fibrin sealant compositions and methods for utilizing same.
Rothwell, Stephen W.; Krishnamurti, Chitra; Reid, III, Thomas J., Fibrinogen bandages and arterial bleeding models and methods of making and using thereof.
Edwardson Peter A. D.,GBX ; Fairbrother John E.,GBX ; Gardner Ronald S.,GBX ; Hollingsbee Derek A.,GBX ; Cederholm-Williams Stewart A.,GBX, Kit for preparing a fibrin sealant.
Seelich,Thomas; Broermann,Ralf, Method for producing a preparation based on fibrinogen and fibronectin as well as protein compositions obtainable according to this method.
de Maat, Monica Petronella Maria; Koolwijk, Pieter, Method for the acceleration or deceleration of angiogenesis using fibrin matrix formed from increased or decreased HMW/LMW fibrinogen ratio.
Edwardson Peter A. D.,GBX ; Fairbrother John E.,GBX ; Gardner Ronald S.,GBX ; Hollingsbee Derek A.,GBX ; Cederholm-Williams Stewart A.,GBX, Method of making a composition comprising a fibrin monomer.
Murray Douglas G. (Willowdale CAX) Smith Dennis C. (Toronto CAX) Guillet James E. (Don Mills CAX), Method of making a hydrogel-forming wound dressing or skin coating material.
Patat Jean-Louis,FRX ; Delmas Olivier,FRX ; Schmitthaeusler Roland,FRX, Method of preparing a biological glue able to coagulate simply by addition of calcium ions.
Burgess, Willson H.; Greisler, Howard P.; Drohan, William N.; Maciag, Thomas; MacPhee, Martin J., Method of preparing a tissue sealant-treated biomedical material.
Edwardson Peter A. D.,GBX ; Fairbrother John E.,GBX ; Gardner Ronald S.,GBX ; Hollingsbee Derek A.,GBX ; Cederholm-Williams Stewart A.,GBX, Methods and compositions using fibrin monomer to make a fibrin sealant.
McKerracher,Lisa, Methods for making and delivering rho-antagonist tissue adhesive formulations to the injured mammalian central and peripheral nervous systems and uses thereof.
Edwardson Peter A. D.,GBX ; Fairbrother John E.,GBX ; Gardner Ronald S.,GBX ; Hollingsbee Derek A.,GBX ; Cederholm-Williams Stewart A.,GBX, Nondynamic fibrin monomer on bandages, sutures, prostheses and dressings.
Heimburger Norbert (Marburg DEX) Fuhge Peter (Lahntal DEX) Ronneberger Hansjrg (Marburg DEX), One-component tissue adhesive and a process for the production thereof.
Antanavich Richard D. (Paso Robles CA) Dorian Randel (Orinda CA), Plasma concentrate and tissue sealant methods and apparatuses for making concentrated plasma and/or tissue sealant.
Heath David,GBX ; Middleton Sarah Margaret,GBX ; Harris Roy,GBX ; Church Nicola Jane,GBX, Platelet substitutes and conjugation methods suitable for their preparation.
Amery, Michael J.; Sibbons, Paul; Burnett, Stuart; Rickets, Sally-Anne; Edwardson, Peter A. D.; Hughes, Jonathan; Hollingsbee, Derek A.; Cederholm-Williams, Stewart A.; Trumbull, Horace R.; Griffin, , Prevention of post surgical adhesions using a fibrin monomer sealant.
Edwardson Peter A. D.,GBX ; Fairbrother John E.,GBX ; Gardner Ronald S.,GBX ; Hollingsbee Derek A.,GBX ; Cederholm-Williams Stewart A.,GBX, Solid compositions of fibrin monomer.
Drohan,William N.; MacPhee,Martin J.; Burgess,Wilson H.; Nunez,Hernan; Singh,Manish; Liau,Gene; Maciag,Thomas, Supplemented and unsupplemented tissue sealants, methods of their production and use.
MacPhee,Martin J.; Drohan,William N.; Liau,Gene; Nunez,Hernan; Burgess,Wilson H.; Hollinger,Jeffrey O.; Maciag,Thomas, Supplemented and unsupplemented tissue sealants, methods of their production and use.
MacPhee,Martin J.; Drohan,William N.; Liau,Gene; Nunez,Hernan; Burgess,Wilson H.; Maciag,Thomas; Singh,Manish, Supplemented and unsupplemented tissue sealants, methods of their production and use.
MacPhee,Martin James; Drohan,William Nash; Liau,Gene; Nunez,Hernan; Burgess,Wilson H.; Maciag,Thomas, Supplemented and unsupplemented tissue sealants, methods of their production and use.
Bass Lawrence S. (Little Neck NY) Libutti Steven K. (Fort Lee NJ) Eaton Alexander M. (Durham NC), Tissue bonding and sealing composition and method of using the same.
Bass Lawrence S. (Little Neck NY) Libutti Steven K. (Lido Beach NY) Eaton Alexander M. (New York NY), Tissue bonding and sealing composition and method of using the same.
Wadstrom Jonas (Dag Hammarskjolds vag 281 S-756 52 Uppsala SEX), Tissue treatment composition comprising fibrin or fibrinogen and biodegradable and biocompatible polymer.
Tse Daphne C. ; Mankarious Samia S. ; Liu Shu Len ; Thomas William R. ; Alpern Melaine ; Enomoto Stanley T. ; Garanchon Cataline M., Topical fibrinogen complex.
Rivlin Jonathan B. (East Brunswick NJ) Vodoor Sam B. (Parlin NJ) Herring William A. (Appelton WI), Water activated adhesive and paper-plastic tape containing same.
Mumper, Russell; Jay, Michael, pH-sensitive mucoadhesive film-forming gels and wax-film composites suitable for topical and mucosal delivery of molecules.
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