[특허]Stirred tank reactor systems and methods of use

Stirred tank reactor systems and methods of use 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	C12M-001/06 B01F-007/00 B01F-007/16 B01F-007/22 B01F-015/00 C12M-001/00
출원번호	US-0109684 (2013-12-17)
등록번호	US-9540606 (2017-01-10)
발명자 / 주소	Kunas, Kurt T. Oakley, Robert V. Hasan, Fauad F. Goodwin, Michael E. Larsen, Jeremy K. Jones, Nephi D.
출원인 / 주소	Life Technologies Corporation
대리인 / 주소	Workman Nydegger
인용정보	피인용 횟수 : 0 인용 특허 : 36

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A method of mixing a fluid includes positioning a flexible bag into the chamber of a support housing, the support housing having a plurality of baffles positioned so that the bag folds around the baffles. A fluid is delivered into a compartment of the flexible bag. A mixing element, such as an impel

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1. A method of mixing a fluid, the method comprising: positioning a flexible bag into a chamber of a support housing;delivering a fluid into a compartment of the flexible bag; andmoving a mixing element within the compartment of the flexible bag so as to mix the fluid therein, the step of moving the mixing element comprising: removably inserting a drive shaft into a tubular connector having a first end and an opposing second end, the first end of the tubular connector being connected to the bag, the second end of the tubular connector being secured to an impeller disposed within the compartment of the flexible bag; androtating the drive shaft so that the impeller rotates relative to the bag. 2. The method as recited in claim 1, wherein the step of delivering the fluid comprises delivering a culture comprising cells or microorganisms. 3. The method as recited in claim 1, further comprising the first end of the tubular connected being rotatably secured to the bag so that rotation of the drive shaft facilitates concurrent rotation of the impeller and the tubular connector. 4. The method as recited in claim 3, further comprising a casing mounted to the flexible bag and a hub rotatably mounted to the casing, the hub having a passageway extending therethrough, the first end of the tubular connector being secured to the hub. 5. The method as recited in claim 4, wherein the drive shaft engages the hub so that rotation of the drive shaft rotates the hub. 6. The method as recited in claim 1, further comprising securing an end of the drive shaft to the impeller. 7. A reactor system comprising: a support housing having an interior surface bounding a chamber;a flexible bag having an interior surface bounding a compartment, the flexible bag being disposed within the chamber of the support housing;an elongated tubular connector disposed within the compartment of the flexible bag, the tubular connector having a first end connected to the bag and an opposing second end disposed within the compartment;a mixing element disposed within the compartment of the flexible bag, the mixing element being coupled with the second end of the tubular connector; anda drive shaft removably received within the tubular connector such that rotation of the drive shaft facilitates rotation of the mixing element. 8. The reactor as recited in claim 7, wherein the mixing element comprises an impeller disposed within the compartment of the flexible bag. 9. The reactor as recited in claim 7, further comprising a rotational assembly which includes a casing mounted to the flexible bag and a hub rotatably mounted to the casing, the hub having a passageway extending therethrough, the first end of the tubular connector being secured to the hub. 10. The reactor system as claimed in claim 9, wherein the drive shaft engages the hub such that rotation of the drive shaft facilitates rotation of the hub. 11. The reactor system as claimed in claim 9, wherein rotation of the drive shaft facilitates rotation of the mixing element, hub, and tubular connector. 12. The reactor system as claimed in claim 7, wherein the tubular connector comprises a flexible tube. 13. The reactor system as recited in claim 7, wherein the first end of the tubular connector is rotatably coupled with the flexible bag. 14. The reactor system as recited in claim 7, further comprising: a housing;a motor mount disposed on the housing and having a passage extending therethrough; anda drive motor coupled with the motor mount for selectively rotating the motor mount relative to the housing, the drive shaft being engaged with the motor mount so that rotation of the motor mount by the drive motor facilitates rotation of the drive shaft.

이 특허에 인용된 특허 (36)

Alexandre Terentiev, Apparatus and method for mixing materials sealed in a container under sterile conditions.
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Todd John J. (61 Sandy Lane Hampshire GBX), Apparatus for the gasification of liquids.
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Matkovich, Vlado Ivan; Bormann, Thomas J.; Delgiacco, Gerard R.; Franovic, Mladen, Connector assemblies, fluid systems, and methods for making a connection.
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Saito Tatsuhiko (Machida JPX) Takabatake Hikaru (Tokyo JPX) Mori Hiroaki (Tokyo JPX) Ida Masahiro (Tokyo JPX) Orii Takeshi (Yachiyo JPX), Continuous flow type homogenizer.
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Pfeifer Arnd,DEX, Device for assembling a servo valve.
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Burris William A. (7 E. Jefferson Cir. Pittsford NY 14534), Diffuser and diffusing method using dual surface tensions.
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Ekambaram Anand ; Radcliff Wendy L. ; Rienstra Mark S. ; Allred Brett L. ; Stewart Doyle W., Disposable storage, transport and resuspension system.
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Bravo Francesco (Montecchio Maggiore ITX), Ellipsoidal pasteurizer for food mixtures.
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Curtis, Wayne R., Growing cells in a reservoir formed of a flexible sterile plastic liner.
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Bacehowski David (Wildwood IL) Bilstad Arnold (Deerfield IL) Keilman Michael R. (Mundelein IL), Large volume flexible containers.
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Curtis Wayne R., Method and apparatus for aseptic growth or processing of biomass.
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Bibbo,Kenneth L.; Elgan,Gregory P.; Goodwin,Michael; Buchanan,Bradley; Austin,Jim, Methods for mixing solutions.
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Renfro,Charles K., Mixing apparatus having rotational and axial motion.
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Terentiev,Alexandre N.; Terentyev,Sergey, Mixing bag with integral sparger and sensor receiver.
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Stewart Doyle W., Mixing block for resuspension system.
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Castillo, Jose; Bosco, Florence; Osumba, Samuel, Mixing system including a flexible bag, specific flexible bag and locating system for the mixing system.
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West, Derik R.; Woods, Whitt F.; Larsen, Jeremy K.; Jones, Nephi D.; Oakley, Robert V.; Kunas, Kurt Thomas; Hasan, Fauad F., Mixing systems and related mixers.
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Bragos Bardia,Ramon; Rosell Ferrer,Javier; Riu Costa,Pere Joan; Godia Casablancas,Francesc; Cairo Badillo,Jordi Joan; Paredes Mu��oz,Carles; Rodriguez Omedes,Ferran, Modular system comprising multiple automated mini-bioreactors for high-throughput screening (HTS) in biotechnology.
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Cummings, Donald D.; Wickens, Geoffrey W.; Lucey, R. Todd; Hockemeyer, Todd M., Mounting system and retractable sensor holder for analytical sensors.
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Schroth Volkmar (Nrnberg DEX) Levin Horst (Lauf DEX), Phase control loop with interrupted control.
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Kunas, Kurt T.; Oakley, Robert V.; Hasan, Fauad F.; Goodwin, Michael E.; Larsen, Jeremy K.; Jones, Nephi D., Probe connector assembly and method of use.
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Vallot Bernard,FRX, Rigid containers for transporting sachets of bio-pharmaceutical fluid products.
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Kennedy Richard B. (519 Branchville Rd. Ridgefield CT 06877), Rotary mixing of two component resins in disposable plastic bag.
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Vallot Bernard,FRX, Sachets for bio-pharmaceutical fluid products.
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Goodwin,Michael E., Sampling ports and related container systems.
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Kunas, Kurt T.; Oakley, Robert V.; Hasan, Fauad F.; Goodwin, Michael E.; Larsen, Jeremy K.; Jones, Nephi D., Stirred tank reactor systems and methods of use.
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Kunas,Kurt T.; Oakley,Robert V.; Hasan,Fauad F.; Goodwin,Michael E.; Larsen,Jeremy K.; Jones,Nephi D., Stirred-tank reactor system.
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Bibbo, Kenneth L.; Elgan, Gregory P.; Goodwin, Michael; Buchanan, Bradley; Austin, Jim; Wages, William; Branch, Claudio; Otto, Jr., Francis J., Systems for mixing liquid solutions and methods of manufacture.
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