Compositions and methods for controlling arthropod parasite and pest infestations
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
C12N-015/113
A01K-051/00
A61K-031/713
A01N-037/46
A01N-063/02
출원번호
US-0532596
(2014-11-04)
등록번호
US-9540642
(2017-01-10)
발명자
/ 주소
Inberg, Alex
Kapoor, Mahak
Evans, Jay
출원인 / 주소
The United States of America, as represented by the Secretary of Agriculture
대리인 / 주소
Carmany-Rampey, Amanda
인용정보
피인용 횟수 :
0인용 특허 :
212
초록▼
This application provides and discloses anti-parasitic, anti-pest or insecticidal nucleic acid molecules and their calmodulin target genes for the control of arthropod parasites and pests. This application further provides methods and compositions for the control and treatment of parasites and pests
This application provides and discloses anti-parasitic, anti-pest or insecticidal nucleic acid molecules and their calmodulin target genes for the control of arthropod parasites and pests. This application further provides methods and compositions for the control and treatment of parasites and pests in Apis mellifera (honey bee) hives.
대표청구항▼
1. A bee-ingestible, bee-absorbable, mite-ingestible, or mite-absorbable composition comprising an excipient and a nucleic acid molecule having a sequence that is at least 96% identical or complementary to at least 21 contiguous nucleotides of SEQ ID NO: 3. 2. The composition of claim 1, wherein sai
1. A bee-ingestible, bee-absorbable, mite-ingestible, or mite-absorbable composition comprising an excipient and a nucleic acid molecule having a sequence that is at least 96% identical or complementary to at least 21 contiguous nucleotides of SEQ ID NO: 3. 2. The composition of claim 1, wherein said nucleic acid sequence is a dsRNA. 3. The composition of claim 1, wherein said excipient is selected from the group consisting of protein, pollen, carbohydrate, polymer, liquid solvent, sugar syrup, sugar solid, and semi-solid feed. 4. The composition of claim 2, wherein said dsRNA is an siRNA. 5. The composition of claim 1, wherein said nucleic acid sequence comprises at least 23 contiguous nucleotides of SEQ ID NO: 3. 6. The composition of claim 2, wherein said dsRNA sequence comprises at least 23 contiguous nucleotides of SEQ ID NO: 3. 7. A nucleic acid construct comprising a nucleic acid that encodes a sequence that is at least 95% identical or complementary to SEQ ID NO: 3 operably linked to a promoter sequence functional in a host cell and capable of producing a dsRNA when introduced into said host cell. 8. The nucleic acid construct of claim 7, further comprising at least one regulatory element selected from the group consisting of translation leader sequences, introns, enhancers, stem-loop structures, repressor binding sequences, termination sequences, pausing sequences, and polyadenylation recognition sequences. 9. The nucleic acid construct of claim 7, wherein said host cell is selected from the group consisting of a bacteria cell and a yeast cell. 10. A method of providing a composition to a honeybee, comprising providing the bee an effective amount of the composition of claim 1, whereby the nucleic acid is present in honeybee tissue. 11. The method of claim 10, wherein said calmodulin gene sequence is a Varroa destructor calmodulin gene sequence. 12. The method of claim 10, wherein said honeybee is a forager or a hive bee. 13. The method of claim 11, wherein said honeybee is a bee of a colony and said providing reduces the susceptibility of said bee colony to Varroa destructor, reduces the parasitation of said bee colony by Varroa destructor, or reduce the parasite load of said bee colony by Varroa destructor. 14. The method of claim 11, wherein said providing reduces the susceptibility of said honeybee to Varroa destructor, reduces the parasitation of said honeybee by Varroa destructor, or reduce the parasite load of said honeybee by Varroa destructor. 15. The composition of claim 1, further comprising one or more nucleic acid molecules having a second nucleic acid sequence that is essentially identical or essentially complementary to a different region of a calmodulin gene sequence.
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Tkachuk Zenovy (Kiev SUX) Kvasyuk Eugeny (Kiev SUX) Matsuka Gennady (Kiev SUX) Mikhailopulo Igor (Kiev SUX), (2′-5′) oligoadenylate analogues useful as inhibitors of host-v5.-graft response.
Suhadolnik Robert J. (Roslyn PA) Pfleiderer Wolfgang (Constance DEX), 2′,5′-phosphorothioate oligoadenylates and their covalent conjugates with polylysine.
Kumakura Manami (Saitama JPX) Kawai Toshikazu (Saitama JPX), Absorption of carbon dioxide gas contained in exhalation of inhalation anesthetic subject.
Summerton James E. (Corvallis OR) Weller Dwight D. (Corvallis OR) Stirchak Eugene P. (Corvallis OR), Alpha-morpholino ribonucleoside derivatives and polymers thereof.
Anderson Paul C. ; Chomet Paul S. ; Griffor Matthew C. ; Kriz Alan L., Anthranilate synthase gene and method of use thereof for conferring tryptophan overproduction.
Cook Phillip D. (Carlsbad CA) Sanghvi Yogesh S. (San Marcos CA) Vasseur Jean J. (San Marcos CA) Debart Francoise (Montpellier FRX), Backbone modified oligonucleotide analogues.
Sanghvi Yogesh S. (San Marcos CA) Cook Phillip D. (Vista CA), Backbone-modified oligonucleotide analogs and preparation thereof through radical coupling.
Felgner Philip L. (Rancho Santa Fe CA) Kumar Raj (San Diego CA) Basava Channa (San Diego CA) Border Richard C. (Poway CA) Hwang-Felgner Jiin-Yu (Rancho Santa Fe CA), Cationic lipids for intracellular delivery of biologically active molecules.
Herrera-Estrella Luis,BEX ; Van Den Broeck Guidi,BEX ; Van Montagu Marc,BEX ; Schreier Peter,DEX ; Schell Josef,DEX ; Bohnert Hans J. ; Cashomore Anthony R. ; Timko Michael P. ; Kausch Albert P., Chimaeric gene coding for a transit peptide and a heterologous polypeptide.
Chaubet Nicole (Strasbourg FRX) Gigot Claude (Strasbourg FRX) Freyssinet Georges (St Cyr au Mont d\Or FRX) Leroux Bernard (Lozanne FRX), Chimeric gene comprising the arabidopsis histone H4 promoter for the transformation of plants.
Pallett, Ken; Derose, Richard; Pelissier, Bernard; Sailland, Alain, Chimeric gene with several herbicide tolerance genes, plant cell and plant resistant to several herbicides.
Boudec, Philippe; Bourdon, Hélène; Dumas, Florence; Rodgers, Matthew; Sailland, Alain, Chimeric hydroxyl-phenyl pyruvate dioxygenase, DNA sequence and method for obtaining plants containing such a gene, with herbicide tolerance.
Ito Kengo (Miyagi JPX) Mizumachi Motohiro (Miyagi JPX) Fujiwara Yoshio (Miyagi JPX) Shinohara Satoru (Miyagi JPX), Composition for fixing water-color ink, cover film for thermal transfer image using composition for fixing water color-i.
Ren, Peifeng; Huang, Xiang; Chaudhuri, Sumita; Talton, Lawrence; McMillan, John, Compositions and methods using RNA interference for control of nematodes.
Volrath Sandra L. ; Johnson Marie A. ; Ward Eric R. ; Heifetz Peter B., DNA molecules encoding plant protoporphyrinogen oxidase and inhibitor-resistant mutants thereof.
Sailland Alain,FRX ; Rolland Anne,FRX ; Matringe Michel,FRX ; Pallett Ken,GBX, DNA sequence of a gene of hydroxy-phenyl pyruvate dioxygenase and production of plants containing a gene of hydroxy-phenyl pyruvate dioxygenase and which are tolerant to certain herbicides.
Baxter Anthony D. (Northwich GB2) Baylis Eric K. (Stockport GB2) Collingwood Stephen P. (Westhoughton GB2) Taylor Roger J. (Stretford GB2) De Mesmaeker Alain (Kanerkinden CHX) Schmit Chantal (Basel C, Dinucleoside phosphinates and their pharmaceutical compositions.
Bouix Herv (Marly le Roi FRX) de Laforcade Vincent (Clamart FRX), Dispensing device for a receptacle containing a product of liquid to pasty consistency.
Le Pennec,Jean Fran��ois; Bruno,Aur��lien; Grisi,Nicolas; Sommerlatt,Jean Marie, Firewall system for interconnecting two IP networks managed by two different administrative entities.
Moriyuki Naosuke (Takasaki JPX) Yamamoto Yoshimasa (Fujioka JPX) Shimosada Hajime (Tokyo JPX), Gas generating agent and gas generator for automobile air bags.
Burle G. Gengenbach ; David A. Somers ; Margaret A. Egli ; Lorelei C. Marshall ; Donald L. Wyse ; Shelia M. Lutz ; Kevin L. Van Dee ; William B. Parker, Gene combinations for herbicide tolerance in corn.
Bartsch Klaus,DEX ; Kriete Guido,DEX ; Broer Inge,DEX ; Puhler Alfred,DEX, Genes coding for amino acid deacetylases with specificity for N-acetyl-L-phosphinothricin, their isolation and their use.
Leemans Jan (Heusden BEX) Botterman Johan (Zwijnaarde BEX) De Block Marc (Gentbrugge BEX) Thompson Charles (Grand Lancy/Genege CHX) Mouva Rao (Genev CHX), Genetically engineered plant cells and plants exhibiting resistance to glutamine synthetase inhibitors, DNA fragments an.
Leemans Jan (Heusden BEX) Botterman Johan (Zwijnaarde BEX) De Block Marc (Gentbrugge BEX) Thompson Charles (Grand Lancy/Genege CHX) Mouva Rao (Geneva CHX), Genetically engineered plant cells and plants exhibiting resistance to glutamine synthetase inhibitors, DNA fragments an.
Leemans Jan (Heusden BEX) Botterman Johan (Zwijnaarde BEX) Thompson Charles (Grand Lancy/Genege CHX) Mouva Rao (Geneva CHX), Genetically engineered plant cells and plants exhibiting resistance to glutamine synthetase inhibitors, DNA fragments an.
Shah Dilip M. (Creve Coeur MO) Rogers Stephen G. (Brussels MO BEX) Horsch Robert B. (St. Louis MO) Fraley Robert T. (St. Louis MO), Glyphosate-resistant plants.
Shah Dilip M. (Creve Coeur MO) Rogers Stephen G. (Chesterfield MO) Horsch Robert B. (both St. Louis MO) Fraley Robert T. (both St. Louis MO), Glyphosate-resistant plants.
Eichholtz David A. (St. Louis MO) Gasser Charles S. (Chesterfield MO) Kishore Ganesh M. (Chesterfield MO), Glyphosate-tolerant 5-enolpyruvyl-3-phosphoshikimate synthases.
Barry Gerard F. (St. Louis MO) Kishore Ganesh M. (Chesterfield MO) Padgette Stephen R. (Grover MO) Stallings William C. (Glencoe MO), Glyphosate-tolerant 5-enolpyruvylshikimate-3-phosphate synthases.
Barry Gerard F. (St. Louis MO) Kishore Ganesh M. (Chesterfield MO) Padgette Stephen R. (Grover MO) Stallings William C. (Glencoe MO), Glyphosate-tolerant 5-enolpyruvylshikimate-3-phosphate synthases.
Barry Gerard Francis ; Kishore Ganesh Murthy ; Padgette Stephen Rogers ; Stallings William Carlton, Glyphosate-tolerant 5-enolpyruvylshikimate-3-phosphate synthases.
Barry Gerard Francis ; Kishore Ganesh Murthy ; Padgette Stephen Rogers ; Stallings William Carlton, Glyphosate-tolerant 5-enolpyruvylshikimate-3-phosphate synthases.
Wands Jack R. (Waban MA) Zurawski ; Jr. Vincent R. (West Chester PA) Schoemaker ; Hubert J. P. (Newton MA), Immunoassay utilizing monoclonal high affinity IgM antibodies.
Cohen Jack S. (Bethesda MD) Neckers Len (Bethesda MD) Stein Cy (Gaithersburg MD) Loke She L. (Wheaton MD) Shinozuka Kazuo (Kazo JPX), Inhibitors for replication of retroviruses and for the expression of oncogene products.
Cohen Jack S. (Bethesda MD) Neckers Len (Bethesda MD) Stein Cy (Gaithersburg MD) Loke She L. (Wheaton MD) Shinozuka Kazuo (Kazo JPX), Inhibitors for replication of retroviruses and for the expression of oncogene products.
Cohen Jack S. (Bethesda MD) Neckers Len (Bethesda MD) Stein Cy (Gaithersburg MD) Loke Shee L. (Wheaton MD) Shinozuka Kazuo (Kazo JPX), Inhibitors for replication of retroviruses and for the expression of oncogene products.
Hemo,Rony; Maoz,Italy; Dloomy,Yarden; Yarden,Gal, Liquid discharge apparatus particularly useful as a portable inoculation gun for anti-virus inoculation of plants.
Haberlein Peter (Reutlingen DEX) Link Hans (Reutlingen DEX), Method and apparatus for adjusting the operating diameter of a probe in a rotating testing head.
Mueller Claus (Kurten DEX) Listner Uwe (Hurth DEX) Schweitzer Martin (Leverkusen DEX), Method and device for the simultaneous dispersion and atomisation of at least two liquids.
Matsunaga Etsuko,JPX ; Kasahara Takehide,JPX ; Sugita Koichi,JPX ; Ebinuma Hiroyasu,JPX, Method for introducing a gene into a plant using an adventitious bud redifferentiation gene under the control of a light-inducible promoter as a selectable marker gene, and vector for introducing a g.
Nakajima,Hiroki; Nagasawa,Akitsu, Method for producing transgenic plants resistant to weed control compounds which disrupt the porphyrin pathways of plants.
Corbin David R. (Chesterfield MO) Greenplate John T. (Manchester MO) Jennings Michael G. (Chesterfield MO) Purcell John P. (Ballwin MO) Sammons Robert D. (Defiance MO), Method of controlling insects.
Smulson Mark E. (Washington DC) Bhatia Kishor (Arbutus MD) Huppi Konrad (Reston VA), Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for hu.
Michael G. Koziel ; Nalini M. Desai ; Kelly S. Lewis ; Vance C. Kramer ; Gregory W. Warren ; Stephen V. Evola ; Lyle D. Crossland ; Martha S. Wright ; Ellis J. Merlin ; Karen L. Launis ; St, Method of producing transgenic maize using direct transformation of commercially important genotypes.
McCutchen, Billy Fred; Chicoine, Timothy K.; Green, Jerry M.; Hazel, Christine B.; Liu, Donglong; Peeples, Kenneth A.; Saunders, David W., Methods and compositions for controlling weeds.
Adams Thomas R. ; Chambers Sheryl A. ; Daines Richard J. ; Gordon-Kamm William J. ; Kausch Albert P. ; Lemaux Peggy G. ; Mackey Catherine J. ; Mangano Mary L. ; O'Brien James V. ; Rice Thomas B. ; Sp, Methods and compositions for the production of stably transformed fertile monocot plants and cells thereof.
Adams Thomas R. ; Chambers Sheryl A. ; Daines Richard J. ; Gordon-Kamm William J. ; Kausch Albert P. ; Lemaux Peggy G. ; Mackey Catherine J. ; Mangano May L. ; O'Brien James V. ; Rice Thomas B. ; Spe, Methods and compositions for the production of stably transformed fertile monocot plants and cells thereof.
Adams Thomas R. (No. Stonington CT) Chambers Sheryl A. (Groton CT) Daines Richard J. (Ledyard CT) Gordon-Kamm William J. (Stonington CT) Kausch Albert P. (Stonington CT) Lemaux Peggy G. (Mystic CT) M, Methods and compositions for the production of stably transformed, fertile monocot plants and cells thereof.
Adams Thomas R. ; Chambers Sheryl A. ; Daines Richard J. ; Gordon-Kamm William J. ; Kausch Albert P. ; Lemaux Peggy G. ; Mackey Catherine J. ; Mangano Mary L. ; O'Brien James V. ; Rice Thomas B. ; Sp, Methods and compositions for the production of stably transformed, fertile monocot plants and cells thereof.
Paul C. Anderson ; Christopher E. Flick ; William J. Gordon-Kamm ; Albert P. Kausch ; Catherine J. Mackey ; Emil M. Orozco ; Peter Orr ; Michael A. Stephens ; David A. Walters ; Donald S. Wa, Methods and compositions for the production of stably transformed, fertile monocot plants and cells thereof.
Baum, James A.; Cajacob, Claire A.; Feldmann, Pascale; Heck, Gregory R.; Nooren, Irene; Plaetinck, Geert; Maddelein, Wendy; Vaughn, Ty T., Methods for genetic control of insect infestations in plants and compositions thereof.
Cheng,Ming; Fry,Joyce E.; Wan,Yeuchun, Methods for the production of stably-transformed, fertile wheat employing agrobacterium-mediated transformation and compositions derived therefrom.
Ward Eric R.,CHX ; Volrath Sandra, Methods of controlling the growth of undesired vegetation with herbicide tolerant plants or plant seeds having altered protoporphyrinogen oxidase activity.
Eichholtz David Alan ; Gasser Charles Scott ; Kishore Ganesh Murthy, Modified gene encoding glyphosate-tolerant 5-enolpruvyl-3-phosphoshikimate synthase.
Matteucci Mark (Burlingame CA) Jones Robert J. (Daly City CA) Munger John (San Francisco CA), Modified internucleoside linkages having one nitrogen and two carbon atoms.
Boudec Philippe,FRX ; Rodgers Matthew,FRX ; Dumas Florence,FRX ; Sailland Alain,FRX ; Bourdon Helene,FRX, Mutated hydroxyphenylpyruvate dioxygenase, DNA sequence and isolation of plants which contain such a gene and which are tolerant to herbicides.
Ts\o Paul O. P. (2117 Folkstone Rd. Lutherville MD 21093) Miller Paul S. (225 Hopkins Rd. Baltimore MD 21212), Nonionic nucleic acid alkyl and aryl phosphonates and processes for manufacture and use thereof.
Bedbrook John R. (Piedmont CA) Chaleff Roy S. (Pennington NJ) Falco Saverio C. (Arden DE) Mazur Barbara J. (Wilmington DE) Somerville Christopher R. (Okemon MI) Yadav Narendra S. (Wilmington DE), Nucleic acid fragment encoding herbicide resistant plant acetolactate synthase.
Bedbrook John R. (Piedmont CA) Chaleff Roy S. (Pennington NJ) Falco Saverio C. (Arden DE) Mazur Barbara J. (Wilmington DE) Somerville Christopher R. (Okemon MI) Yadav Narendra S. (Wilmington DE), Nucleic acid fragment encoding herbicide resistant plant acetolactate synthase.
Bedbrook John R. (Piedmont CA) Chaleff Roy S. (Pennington NJ) Falco Saverio C. (Arden DE) Mazur Barbara J. (Wilmington DE) Somerville Christopher R. (Portola Valley CA) Yadav Narendra S. (Wilmington , Nucleic acid fragment encoding herbicide resistant plant acetolactate synthase.
Bedbrook John R. (Piedmont CA) Chaleff Roy S. (Pennington NJ) Falco Saverio C. (Arden DE) Mazur Barbara J. (Wilmington DE) Somerville Cristopher R. (Okemon MI) Yadav Narendra S. (Wilmington DE), Nucleic acid fragment encoding herbicide resistant plant acetolactate synthase.
Meyer ; Jr. Rich B. (Woodinville WA) Adams A. David (Snohomish WA) Petrie Charles R. (Woodinville WA), Oligo (aa
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Letsinger Robert L. (Wilmette IL) Gryaznov Sergei M. (San Mateo CA), Oligodeoxyribonucleotides including 3′-aminonucleoside-phosphoramidate linkages and terminal 3′-amino groups.
Bischofberger Norbert (San Carlos CA) Kent Ken (Mountain View CA) Wagner Rick (Burlingame CA) Buhr Chris (Daly City CA) Lin Kuei-Ying (Fremont CA), Oligonucleotide analogs capable of passive cell membrane permeation.
Weis Alexander Ludvik (Berwyn PA) Hausheer Frederick Herman (San Antonio TX) Chaturvedula Prasad Venkata Chala (Exton PA) Delecki Daniel Joseph (Radnor PA) Cavanaugh ; Jr. Paul Francis (West Chester , Oligonucleotide analogues containing phosphate diester linkage substitutes, compositions thereof, and precursor dinucleo.
Imbach Jean-Louis (Montpellier FRX) Gosselin Gilles J. M. (Montpellier FRX), Oligonucleotides, a process for preparing the same and their application as mediators of the action of interferon.
Spielvogel Bernard F. (Raleigh NC) Sood Anup (Durham NC) Hall Iris H. (Chapel Hill NC) Shaw Barbara R. (Durham NC), Oligoribonucleoside and oligodeoxyribonucleoside boranophosphates.
Christou Paul (Madison WI) McCabe Dennis (Middleton WI) Swain William F. (Madison WI) Barton Kenneth A. (Middleton WI), Particle-mediated transformation of soybean plants and lines.
Maddry Joseph A. (Birmingham AL) Reynolds Robert C. (Birmingham AL) Secrist John A. (Birmingham AL) Montgomery John A. (Birmingham AL) Crooks Peter A. (Lexington KY), Polynucleotide analogs containing sulfonate and sulfonamide internucleoside linkages.
Caruthers Marvin H. (Boulder CO) Marshall William S. (Boulder CO) Brill Wolfgang (Freiburg DEX) Nielsen John (Horsholm DKX), Polynucleotide phosphorodithioate.
Adams Thomas R. (North Stonington CT) Chambers Sheryl A. (Groton CT) Daines Richard J. (Ledyard CT) Gordon-Kamm William J. (Stonington CT) Kausch Albert P. (Stonington CT) Lemaux Peggy G. (Mystic CT), Process of producing fertile transgenic zea mays plants and progeny comprising a gene encoding phosphinothrici.
Sanders Jan W.,NLX ; Kok Jan,NLX ; Venema Gerard,NLX ; Ledeboer Adrianus M,NLX, Salt-inducible promoter derivable from a lactic acid bacterium, and its use in a lactic acid bacterium for production of a desired protein.
Sandbrink Joseph J. ; Warner James M. ; Wright Daniel R. ; Feng Paul C. C., Sequential application method for treating plants with exogenous chemicals.
Brian J. Martinell ; Lori S. Julson ; Carol A. Emler ; Yong Huang ; Dennis E. McCabe ; Edward J. Williams, Soybean agrobacterium transformation method.
Stadler Joan K. (3313 Oakland St. Ames IA 50010) Antonelli Nunzio M. (via Pezze del Sole ; 24 Bari ITX 70125), Synergistic method for host cell transformation.
Bullitt, Elizabeth; Aylward, Stephen, Systems, methods, and computer program products for analysis of vessel attributes for diagnosis, disease staging, and surgical planning.
Norris James ; Clawson Gary ; Westwater Caroline ; Schofield David ; Schmidt Michael ; Hoel Brian ; Dolan Joseph ; Pan Wei-Hua, Tissue-specific and pathogen-specific toxic agents and ribozymes.
Hibberd Kenneth A. (Falcon Heights MN) Anderson Paul C. (Minneapolis MN) Barker Melanie (Bloomington MN), Tryptophan overproducer mutants of cereal crops.
Summerton James E. (Corvallis OR) Weller Dwight D. (Corvallis OR), Uncharged morpolino-based polymers having phosphorous containing chiral intersubunit linkages.
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