[특허]IRE-1α inhibitors

IRE-1α inhibitors 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	C07D-213/48 C07C-065/30 A61K-031/11 C07D-333/58 C07C-047/55 C07C-047/565 C07C-047/575 C07D-213/64 C07D-213/69 C07D-213/74 C07D-217/16 C07D-231/12 C07D-239/26 C07D-239/54 C07D-261/08 C07D-277/34 C07D-295/192 C07D-307/80 C07D-317/54 C07D-319/18 C07D-321/10 C07D-333/22 C07D-417/10 A61K-031/135 A61K-031/192 A61K-031/357 A61K-031/381 A61K-031/505 A61K-031/5375 A61K-031/5377 C07C-205/44 C07D-295/125 C07C-235/84 C07C-317/24 C07D-215/14 C07D-241/18 C07D-295/15
출원번호	US-0969837 (2015-12-15)
등록번호	US-9546149 (2017-01-17)
발명자 / 주소	Patterson, John B. Lonergan, David G. Flynn, Gary A. Zeng, Qingpeng Pallai, Peter V.
출원인 / 주소	MannKind Corporation
대리인 / 주소	K&L Gates LLP
인용정보	피인용 횟수 : 1 인용 특허 : 98

초록

Compounds which directly inhibit IRE-1α activity in vitro, prodrugs, and pharmaceutically acceptable salts thereof. Such compounds and prodrugs are useful for treating diseases associated with the unfolded protein response and can be used as single agents or in combination therapies.

대표청구항 ▼

1. A compound or a pharmaceutically acceptable salt thereof, which falls within structural formula (A2): wherein: R1 is hydrogen, halogen, or a 5- or 6-membered heterocyclic containing one or two heteroatoms independently selected from nitrogen, oxygen, and sulfur;R3 is hydrogen, halogen, —NO2, C1-C3 linear or branched alkyl, C1-C3 linear or branched alkoxy, C1-C3 linear or branched hydroxyl alkyl, andR4, R5, and R6 are independently selected from C1-C3 linear or branched alkyl, C1-C3 phenylalkyl, C1-C3 alkoxyphenylalkyl, 2. A compound or a pharmaceutically acceptable salt thereof, which falls within structural formula (A3): wherein R1 is hydrogen;R3 is andQ is selected from the group consisting of 3. A compound or a pharmaceutically acceptable salt thereof, which falls within the scope of formula (A4): wherein: R1 is hydrogen;R3 is hydrogen, —F, —NO2, or R8 is or, together with R9 and the nitrogen atom to which they are attached, is and R9 is hydrogen or, together with R8 and the nitrogen atom to which they are attached, is 4. A pharmaceutical composition comprising a compound of claim 1 or a pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable carrier. 5. A pharmaceutical composition comprising a compound of claim 2 or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier. 6. A pharmaceutical composition comprising a compound of claim 3 or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.

이 특허에 인용된 특허 (98)

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IPC	Description
A	생활필수품
A62	인명구조; 소방(사다리 E06C)
A62B	인명구조용의 기구, 장치 또는 방법(특히 의료용에 사용되는 밸브 A61M 39/00; 특히 물에서 쓰이는 인명구조 장치 또는 방법 B63C 9/00; 잠수장비 B63C 11/00; 특히 항공기에 쓰는 것, 예. 낙하산, 투출좌석 B64D; 특히 광산에서 쓰이는 구조장치 E21F 11/00)
A62B-1/08	.. 윈치 또는 풀리에 제동기구가 있는 것

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연합인증

IRE-1α inhibitors 원문보기

초록

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IRE-1α inhibitors 원문보기

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이 특허에 인용된 특허 (98)

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