The invention provides methods and materials for decontamination of surfaces and fabrics, such as non-woven fabrics, that are contaminated with infestations of microorganisms such as bacteria. Biocidal oligomers having conjugated oligo-(aryl/heteroaryl ethynyl) structures and comprising at least one
The invention provides methods and materials for decontamination of surfaces and fabrics, such as non-woven fabrics, that are contaminated with infestations of microorganisms such as bacteria. Biocidal oligomers having conjugated oligo-(aryl/heteroaryl ethynyl) structures and comprising at least one cationic group can be used to decontaminate infested surfaces in the presence of oxygen and, optionally, illumination. Fibers incorporating biocidal oligomers having conjugated oligo-(aryl/heteroaryl ethynyl) structures and comprising at least one cationic group, wherein the oligomer is physically associated with or covalently bonded to, or both, the fiber-forming polymer can be used to form non-woven mats. Biocidal non-woven mats prepared by methods of the invention, incorporating the biocidal oligomers, can be used to suppress bacterial growth in wound and surgical dressings and personal hygiene products.
대표청구항▼
1. A method of making an antimicrobial fiber for a woven or non-woven fabric, the fiber comprising a biocidal oligomer wherein the biocidal oligomer has the structure: wherein Z− is an anion, k=1-6, and n=1-100;the method comprisingcontacting a fiber-forming polymer and an effective amount of the bi
1. A method of making an antimicrobial fiber for a woven or non-woven fabric, the fiber comprising a biocidal oligomer wherein the biocidal oligomer has the structure: wherein Z− is an anion, k=1-6, and n=1-100;the method comprisingcontacting a fiber-forming polymer and an effective amount of the biocidal oligomer; and,spinning a fiber from the fiber-forming polymer, to provide a fiber comprising the polymer and the biocidal oligomer. 2. The method of claim 1 wherein the spinning comprises a step of any one of meltblowing, melt spinning, dry spinning, wet spinning, gel spinning, single head electrospinning, multihead electrospinning, or flash spinning; the method optionally further comprising a step to orient the fibers, stretch the fibers, or both. 3. The method of claim 1, further comprising accumulating the fiber after spinning into a nonwoven mat. 4. The method of claim 1 wherein the polymer and the biocidal oligomer can react to form a covalently coupled biocidal oligomer-polymer composition. 5. The method of claim 1 wherein the polymer is polyester, a polyvinyl alcohol, a polyethylene oxide, a polyolefin, a cellulosic, a chitosan, an alginate, or a gelatin, or any mixture or blend thereof. 6. The method of claim 1 wherein the polymer comprises an azido group, and the biocidal oligomer and the polymer are mutually covalently reacted using click chemistry. 7. The method of claim 1 wherein e spun fiber comprising the biocidal oligomer possesses greater biocidal properties versus microorganisms in the presence of oxygen than does a comparable spun fiber lacking the biocidal oligomer. 8. The method of claim 1 wherein the biocidal properties of the spun fiber versus microorganisms in the presence of oxygen is increased under illumination by visible or ultraviolet light. 9. The method of claim 1, wherein the fiber-forming polymer and the biocidal oligomer are contacted prior to spinning a fiber from the fiber-forming polymer. 10. The method of claim 1, wherein the fiber-forming polymer and the biocidal oligomer are contacted subsequent to spinning a fiber from the fiber-forming polymer. 11. A fiber prepared by the method of claim 1. 12. A non-woven mat comprising the fiber of claim 11. 13. A surgical or wound dressing, a personal hygiene product, or a garment comprising the mat of claim 12. 14. A woven cloth comprising the fiber of claim 11. 15. A surgical or wound dressing, a personal hygiene product, or a garment comprising the woven cloth of claim 14.
Liu Jia M. (Hsinchu RI TWX) Sun Linfeng (Kingston RI) Yang Sze C. (Kingston RI), Molecular complex of conductive polymer and polyelectrolyte; and a process of producing same.
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