Disclosed is a device useful for preserving tissue samples after extraction from human or animal patients. The device includes a circular blade for taking a tissue sample, the blade being coupled to a sealing cap which mates to one end of a container. A retrieval port is also disclosed for extractin
Disclosed is a device useful for preserving tissue samples after extraction from human or animal patients. The device includes a circular blade for taking a tissue sample, the blade being coupled to a sealing cap which mates to one end of a container. A retrieval port is also disclosed for extracting fluids from the container. Methods are also disclosed by which tissue samples may be taken and prepared for storage, processing, culture, or other analysis.
대표청구항▼
1. A tissue extraction vial comprising: a container having a mouth and a retrieval port, wherein the retrieval port has a closure configured to permit access into the container;a cap, anda blade attached to the cap and configured to capture a tissue sample;wherein the cap is adapted to sealingly mat
1. A tissue extraction vial comprising: a container having a mouth and a retrieval port, wherein the retrieval port has a closure configured to permit access into the container;a cap, anda blade attached to the cap and configured to capture a tissue sample;wherein the cap is adapted to sealingly mate with the mouth of the container;wherein the blade is a punch-biopsy blade and has a first end attached to the cap without passing through the closure when the cap is sealingly mated with the mouth of the container;wherein the blade has a second end extending away from the cap and into the container; and wherein the container, closure, blade, and cap are arranged to maintain a fluid-tight seal when the cap is sealingly mated with the mouth of the container with the first end and second end of the blade positioned lateral to the closure. 2. The tissue extraction vial of claim 1 wherein the blade defines an internal lumen. 3. The tissue extraction vial of claim 2 wherein the blade is circular. 4. The tissue extraction vial of claim 3 wherein the circular blade has a diameter between about 2 mm and about 4 mm. 5. The tissue extraction vial as in claim 1 wherein the blade is made of stainless steel. 6. The tissue extraction vial as in claim 1 wherein the blade has a height of about 5 mm. 7. The tissue extraction vial of claim 1 further comprising: a plunger, wherein the plunger is configured to dislodge the tissue sample from the blade. 8. The tissue extraction vial as in claim 1 wherein the closure is a septum that can be pierced by a needle. 9. The tissue extraction vial as in claim 1 further comprising a liquid medium inside the container; wherein the liquid medium is in fluid communication with the blade when the cap is sealingly mated with the mouth of the container, without the blade passing through the closure. 10. The tissue extraction vial as in claim 9 wherein the liquid medium is a solution. 11. The tissue extraction vial as in claim 9 further comprising a chemical preservative capable of preserving the tissue sample inside the container. 12. The tissue extraction vial as in claim 9 further comprising a preservative with a permeable cryoprotectant agent inside the container. 13. The tissue extraction vial as in claim 9 further comprising one of the following preservatives inside the container: dimethyl sulfoxide, ethylene glycol, propylene glycol, or glycerol. 14. The tissue extraction vial as in claim 9 further comprising an enzyme effective to digest a tissue sample inside the container. 15. The tissue extraction vial of claim 1 wherein the retrieval port is at one end of the container, and the mouth is at an other end of the container. 16. A tissue extraction vial comprising: a container having a mouth and defining an interior cavity;a cap configured to fluidly seal the mouth of the container;a blade configured to capture a tissue sample, wherein the blade has a first end attached to the cap and a second end extending away from the cap;a needle-penetrable septum adapted to provide access into the interior cavity of the container; andwherein the blade is a punch-biopsy blade configured to pass through the mouth of the container without passing through the needle-penetrable septum; andwherein the first end and second end of the blade are positionable within the interior cavity of the container and lateral to the needle-penetrable septum. 17. The vial of claim 16 wherein the blade is receivable within the container when the cap is mated to the container. 18. A cap assembly for capping a container, comprising: a cap mateable with a mouth of a container;a needle-penetrable septum mounted in the cap and adapted to provide access through the cap into the container when the cap is mated to the mouth of the container;a blade configured to capture a tissue sample, wherein the blade is a punch-biopsy blade and has a first end attached to the cap adjacent the needle-penetrable septum, and a second end extending away from the needle-penetrable septum and into the container when the cap is mated therewith; andwherein the blade is configured to pass through the mouth of the container without passing through the needle-penetrable septum when the cap is mated with the container; andwherein the cap fluidly seals the mouth of the container when mated with the container. 19. The cap assembly of claim 18, wherein the blade defines an inner lumen having a longitudinal axis, and wherein at least a portion of the septum is aligned with said longitudinal axis. 20. The tissue extraction vial of claim 1, wherein the mouth is at one end of the container and the retrieval port is at another end of the container. 21. The tissue extraction vial of claim 16 wherein the needle-penetrable septum is mounted in the cap. 22. The tissue extraction vial of claim 16 wherein the needle-penetrable septum is mounted in the container. 23. The tissue extraction vial of claim 22, wherein the mouth is at one end of the container and the needle-penetrable septum is at another end of the container. 24. The vial of claim 16, wherein the cap includes a threaded portion arranged to engage a threaded portion of the container. 25. The vial of claim 16, wherein a portion of the cap is received within the container and contacts an inside wall of the container when the cap is engaged with the mouth of the container. 26. The cap assembly of claim 18, wherein the needle-penetrable septum has a distal surface facing away from the container when the cap is mated with the container; and wherein the needle-penetrable septum is distal the first end of the blade and the first end of the blade is distal of the second end of the blade. 27. A tissue extraction vial, comprising: a container defining an interior cavity and having a mouth opening to the interior cavity;a cap configured to sealingly mate with the mouth of the container;a retrieval port having a closure configured to permit access to the interior cavity of the container;a blade having a first end terminating in a material of the cap and a second end of the blade extending away from the cap and into the interior cavity of the container when the cap is sealingly mated with the mouth of the container, without the blade passing through the closure; andwherein the blade is a punch-biopsy blade and is anchored within the cap so that the blade can be rotated by rotating the cap in the capture of a tissue sample; andwherein the container, the cap, and the blade are arranged to maintain a fluid-tight seal when the cap is sealingly mated with the mouth of the container, with the second end of the blade positioned within the interior of the container. 28. The tissue extraction vial of claim 27, wherein: the retrieval port is mounted in the cap;wherein the retrieval port is aligned with the blade such that a needle inserted through said cap and into an interior of the blade would extend through said retrieval port; andwherein the second end of the blade is suspended in the interior cavity of the container and is above a bottom surface of the container when the cap is sealingly mated with the mouth of the container, without the blade passing through the closure. 29. The tissue extraction vial of claim 27, comprising: a liquid positioned within the interior cavity of the container and in fluid communication with the second end of the blade when the cap is sealingly mated with the mouth of the container, with the second end of the blade positioned within the interior of the container without the blade passing through the closure. 30. The tissue extraction vial of claim 27, wherein: the retrieval port is mounted in the cap. 31. The tissue extraction vial of claim 30, wherein: the retrieval port is aligned with the blade such that a needle inserted through said cap and into an interior of the blade would extend through said retrieval port. 32. The tissue extraction vial of claim 27, wherein: the retrieval port is mounted in the container. 33. The tissue extraction vial of claim 27, wherein: the second end of the blade is suspended in the interior cavity of the container and is above a bottom surface of the container when the cap is sealingly mated with the mouth of the container. 34. The tissue extraction vial of claim 27, wherein the blade includes teeth. 35. The cap assembly of claim 26, wherein the needle-penetrable septum is accessible to be pierced by a needle of a syringe when the cap is mated with the container.
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