초록

A microprotrusion array for use in transport of a material across a biological barrier, wherein said array comprises a plurality of microprotusions composed of a swellable polymer composition.

대표청구항 ▼

1. A microprotrusion array for use in transport of a material across a biological barrier, wherein said array comprises a plurality of microprotrusions composed of a swellable polymer composition which in its dry state is hard and brittle to penetrate the stratum corneum of mammalian skin, wherein t

1. A microprotrusion array for use in transport of a material across a biological barrier, wherein said array comprises a plurality of microprotrusions composed of a swellable polymer composition which in its dry state is hard and brittle to penetrate the stratum corneum of mammalian skin, wherein the microprotrusions are fabricated from at least one polymer selected from poly(methylvinylether/maleic acid), esters thereof and poly (methyl/vinyl ether/maleic anhydride), wherein the polymer is a cross-linked polymer, and using a cross-linker at a polymer-crosslinker ratio of 2:1. 2. The microprotrusion array of claim 1 wherein the microprotrusions can puncture the stratum corneum of mammalian skin and, in use, upon insertion into the skin, the microprotrusions swell. 3. The microprotrusion array of claim 1, wherein the array comprises a plurality of groups of microprotrusions, wherein the microprotrusions of each group differ in size and/or composition from those of each other group. 4. The microprotrusion array of claim 3, wherein the microprotrusions of a first group comprises at least one different cross-linker to the cross-linker of the microprotrusions of a second group. 5. The microprotrusion array of claim 1, wherein the microprotrusions are 1-3000 μm in height. 6. The microprotrusion array of claim 1, wherein the microprotrusions have a diameter of 50-300 μm. 7. The microprotrusion array of claim 1, wherein the polymer is selected from one of poly(methylvinylether/maleic acid) and poly(methyl/vinyl ether/maleic anhydride), cross-linked using a polyhydric alcohol. 8. The microprotrusion array of claim 1, wherein the polymer composition comprises an active agent. 9. A transdermal delivery device comprising a microprotrusion array wherein said array comprises a plurality of microprotrusions composed of a swellable polymer composition which in its dry state is hard and brittle to penetrate the stratum corneum of mammalian skin, wherein the microprotrusions are fabricated from at least one polymer selected from poly(methylvinylether/maleic acid), esters thereof and poly (methyl/vinyl ether/maleic anhydride), wherein the polymer is a cross-linked polymer and comprising a reservoir, wherein said reservoir comprises an active agent. 10. The transdermal delivery device of claim 9 wherein, on insertion of the microprotrusion array into skin, the microprotrusions are adapted to swell to form a swollen matrix and allow diffusion of the active agent stored in the reservoir or matrix through the swollen matrix, providing movement of the active agent through microprotrusions to the skin. 11. The transdermal delivery device of claim 9, wherein the movement active agent moves from the reservoir or matrix through microprotrusions to the skin of the active agent is by iontophoresis. 12. The transdermal delivery device of claim 9, wherein the microprotrusions are fabricated using a cross-linker alcohol at a polymer-crosslinker ratio of 2:1. 13. A microprotrusion array for the administration of an active agent in a reservoir to a tissue of a subject in need thereof, wherein said array comprises a plurality of microprotrusions composed of a swellable polymer composition which in its dry state is hard and brittle to penetrate which in its dry state is hard and brittle to penetrate the stratum corneum of mammalian skin, wherein the microprotrusions are fabricated from at least one polymer selected from poly(methylvinylether/maleic acid), esters thereof and poly (methyl/vinyl ether/maleic anhydride), wherein the polymer is a cross-linked polymer, said administration comprising the steps of: applying the microprotrusion array to the skin such that the microprotrusions protrude through or into the stratum corneum,allowing the microprotrusions to swell, andallowing the active agent to flow from the reservoir through the microprotrusions and into the skin. 14. The microprotrusion array of claim 13, wherein the active agent is a drug, a cosmetic compound or a nutrient. 15. The microprotrusion array of claim 13, wherein the microprotrusions are fabricated using a cross-linker alcohol at a polymer-crosslinker ratio of 2:1. 16. An iontophoretic device comprising a microprotrusion array, wherein said array comprises a plurality of microprotrusions composed of a swellable polymer composition which in its dry state is hard and brittle to penetrate the stratum corneum of mammalian skin, wherein the microprotrusions are fabricated from at least one polymer selected from poly(methylvinylether/maleic acid), esters thereof and poly (methyl/vinyl ether/maleic anhydride), wherein the polymer is a cross-linked polymer, and using a cross-linker at a polymer-crosslinker ratio of 2:1.