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| 국가/구분 | United States(US) Patent 등록 |
|---|---|
| 국제특허분류(IPC7판) |
|
| 출원번호 | US-0153245 (2014-01-13) |
| 등록번호 | US-9555145 (2017-01-31) |
| 발명자 / 주소 |
|
| 출원인 / 주소 |
|
| 인용정보 | 피인용 횟수 : 0 인용 특허 : 418 |
A method for removing biofilm from a lumen of a medical implant is disclosed. The method includes the steps of inserting a plasma applicator into a lumen defined in a medical implant, the lumen having a proximal end portion and a distal end portion having an opening therein, positioning the plasma a
A method for removing biofilm from a lumen of a medical implant is disclosed. The method includes the steps of inserting a plasma applicator into a lumen defined in a medical implant, the lumen having a proximal end portion and a distal end portion having an opening therein, positioning the plasma applicator adjacent a biofilm formation, generating a selectively reactive plasma effluent at the plasma applicator and directing the selectively reactive plasma effluent at the biofilm formation.
1. A method for eliminating biofilm from a lumen of a medical implant, the method comprising: inserting a plasma applicator into a lumen defined in a medical implant, the lumen having a proximal end portion and a distal end portion having an opening defined therein;positioning the plasma applicator
1. A method for eliminating biofilm from a lumen of a medical implant, the method comprising: inserting a plasma applicator into a lumen defined in a medical implant, the lumen having a proximal end portion and a distal end portion having an opening defined therein;positioning the plasma applicator adjacent a biofilm formation;generating a selectively reactive plasma effluent at the plasma applicator;directing the selectively reactive plasma effluent at the biofilm formation;completely blocking the opening of the lumen with a seal prior to generating the selectively reactive plasma effluent; andmoving the seal to open the opening, thereby allowing for air to pass through the lumen after stopping generation of the selectively reactive plasma effluent. 2. A method according to claim 1, wherein positioning the plasma applicator adjacent the biofilm includes selectively deflecting a distal portion of the plasma applicator to direct the distal portion toward the biofilm formation. 3. A method according to claim 1, wherein generating the selectively reactive plasma effluent includes: supplying ionizable media and at least one precursor feedstock to the plasma applicator; andigniting the ionizable media and the at least one precursor feedstock at the plasma applicator to form the selectively reactive plasma effluent. 4. A method according to claim 3, wherein generating the selectively reactive plasma effluent includes selecting the at least one precursor feedstock having higher chemical reactivity with the biofilm formation than with the medical implant. 5. A method according to claim 3, wherein the ionizable media is selected from the group consisting of argon and helium. 6. A method according to claim 1, wherein the reactive plasma effluent has a maximum temperature of about 60° C. 7. A method according to claim 1, further comprising measuring at least one spectrum of the reactive plasma effluent. 8. A method according to claim 7, further comprising determining progression of biofilm removal based on the at least one spectrum. 9. A method according to claim 1, further comprising moving the plasma applicator in a distal direction into engagement with the seal, thereby moving the seal into a position in which the seal is blocking the opening of the lumen. 10. A method for removing biofilm from a lumen of an endotracheal tube, the method comprising: inserting a plasma applicator into a lumen of an endotracheal tube;positioning the plasma applicator within the lumen, the plasma applicator including: a shaft having a proximal portion, a deflectable distal portion, and a lumen defined in the shaft, the lumen terminating in an opening at a distal end of the distal portion, the lumen being in fluid communication with an ionizable media source; andat least one electrode disposed at the distal portion and coupled to a power source;generating a selectively reactive plasma effluent at the plasma applicator;moving the plasma applicator along at least a portion of the lumen to apply the selectively reactive plasma effluent at at least one biofilm formation within the lumen and inactivate dispersed biofilm forming bacteria;blocking the opening of the lumen with a seal prior to generating the selectively reactive plasma effluent, the seal being a solid, uninterrupted surface spanning an entirety of the opening of the lumen; andmoving the seal to open the opening of the lumen, thereby allowing for air to pass through the lumen after stopping generation of the selectively reactive plasma effluent. 11. A method according to claim 10, wherein positioning the plasma applicator within the lumen includes selectively deflecting a distal portion of the plasma applicator to direct the distal portion toward the tissue formation. 12. A method according to claim 10, wherein generating the selectively reactive plasma effluent includes selecting at least one precursor feedstock having higher chemical reactivity with the tissue formation than with the tissue cavity. 13. A method according to claim 10, further comprising measuring at least one spectrum of the reactive plasma effluent. 14. A method according to claim 13, further comprising determining progression of biofilm removal based on the at least one spectrum. 15. A method for removing biofilm from a lumen of an endotracheal tube, the method comprising: inserting a plasma applicator into a lumen defined in an endotracheal tube;positioning the plasma applicator adjacent a biofilm formation;supplying ionizable media and at least one precursor feedstock to the plasma applicator;igniting the ionizable media and the at least one precursor feedstock at the plasma applicator to form a selectively reactive plasma effluent;directing the selectively reactive plasma effluent at the biofilm formation;blocking a distal opening of the lumen with a seal prior to forming the selectively reactive plasma effluent, the seal preventing air from passing through the distal opening along a central axis defined through the lumen; andmoving the seal to open the distal opening of the lumen, thereby allowing for air to pass through the lumen after stopping formation of the selectively reactive plasma effluent. 16. A method according to claim 15, wherein positioning the plasma applicator adjacent the biofilm formation includes selectively deflecting a distal portion of the plasma applicator to direct the distal portion toward the biofilm formation. 17. A method according to claim 15, further comprising measuring at least one spectrum of the reactive plasma effluent. 18. A method according to claim 17, further comprising determining progression of biofilm removal based on the at least one spectrum. 19. A method according to claim 1, further comprising preventing generating the selectively reactive plasma effluent upon a sensor of the plasma applicator sensing that the seal is moved to a position in which the opening is open. 20. A method according to claim 10, further comprising: locking controls of the plasma applicator upon a sensor of the plasma applicator sensing that the seal is moved to a position in which the opening is open such that the selectively reactive plasma effluent is not generated in response to an actuation of the controls; andunlocking controls of the plasma applicator upon the sensor sensing that the seal is blocking the opening such that the selectively reactive plasma effluent is generated in response to an actuation of the controls.
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