Implantable biocompatible polymeric medical devices include a substrate with a plasma-modified surface which is subsequently modified to include click reactive members.
대표청구항▼
1. A medical device having a plasma-treated surface that is functionalized with a click reactive member to provide an activated surface on the medical device. 2. The medical device of claim 1, wherein the medical device comprises a biodegradable polymer selected from collagen, cellulose, poly (amino
1. A medical device having a plasma-treated surface that is functionalized with a click reactive member to provide an activated surface on the medical device. 2. The medical device of claim 1, wherein the medical device comprises a biodegradable polymer selected from collagen, cellulose, poly (amino acids), polysaccharides, hyaluronic acid, gut, copolymers and combinations thereof. 3. The method of claim 1, wherein the medical device comprises a non-degradable polymer selected from fluorinated polymers, polyolefins, nylons, polyamides, polyurethanes, silicones, ultra high molecular weight polyethylene, polybutesters, polyaryletherketone, copolymers and combinations thereof. 4. The medical device of claim 1, wherein the click reactive member is selected from the group consisting of thiols, azides, alkynes and alkenes. 5. The medical device of claim 1, wherein the click reactive member comprises a thiol. 6. The medical device claim 1, wherein the click reactive member comprises an azide. 7. The medical device of claim 1, wherein the click reactive member comprises an alkyne. 8. The medical device of claim 1, wherein the click reactive member comprises an alkene. 9. The medical device of claim 1, wherein the medical device is selected from the group consisting of monofilament sutures, multifilament sutures, surgical meshes, ligatures, sutures, staples, slings, patches, foams, pellicles, films, barriers, stents, catheters, and inflatable balloons. 10. A method of preparing a medical device having an activated surface, the method comprising: plasma treating at least a portion of a surface of an absorbable polymeric medical device; andattaching one or more click reactive members to the plasma treated surface of the absorbable polymeric medical device. 11. The method according to claim 10, wherein the plasma treating provides reactive members on the surface of the medical device. 12. The method according to claim 10, wherein the plasma treating provides a coating on the device, the coating including reactive members on the surface of the medical device. 13. The method according to claim 10, wherein the medical device comprises a natural polymer selected from collagen, cellulose, poly (amino acids), polysaccharides, hyaluronic acid, gut, copolymers and combinations thereof. 14. The method according to claim 10, wherein the click reactive member is selected from the group consisting of thiols, azides, alkynes and alkenes. 15. The method according to claim 10, wherein the click reactive member comprises a thiol. 16. The method according to claim 10, wherein the click reactive member comprises an azide. 17. The method according to claim 10, wherein the click reactive member comprises an alkyne. 18. The method according to claim 10, wherein the click reactive member comprises an alkene. 19. The method according to claim 10, wherein the medical device is selected from the group consisting of monofilament sutures, multifilament sutures, surgical meshes, ligatures, sutures, staples, slings, patches, foams, pellicles, films, barriers, stents, catheters, and inflatable balloons. 20. The method according to claim 10, wherein the medical device comprises a synthetic polymer. 21. The method according to claim 10 wherein the plasma treatment lasts less than 5 minutes. 22. The method according to claim 10 further comprising the step of combining the absorbable polymeric medical device with a drug functionalized with one or more complimentary click reactive members to covalently bond the drug to the surface of the absorbable polymeric substrate for drug delivery.
연구과제 타임라인
LOADING...
LOADING...
LOADING...
LOADING...
LOADING...
이 특허에 인용된 특허 (49)
Paul O. Zamora ; Shigemasa Osaki ; Ray Tsang, Amphipathic coating for modulating cellular adhesion composition and methods.
Rowe Stephen C. (Wellesley MA) Hubbell Jeffrey A. (San Marino CA) Herman Stephen J. (Andover MA) Sun Vae (Palo Alto CA) Lang Michael F. (North Andover MA) Selecman George E. (Marblehead MA) Ahari Fre, Apparatus and method for local application of polymeric material to tissue.
Bennett Steven L. (Southington CT) Jiang Ying (North Haven CT) Gruskin Elliott A. (Killingworth CT) Connolly Kevin M. (Hamden CT), Bioabsorbable branched polymers containing units derived from dioxanone and medical/surgical devices manufactured theref.
Fran.cedilla.ois Regis Ory FR; Michel Therin FR; Philippe Gravagna FR; Jean-Louis Tayot FR, Composite prosthesis for preventing post-surgical adhesions and method for obtaining same.
Hubbell, Jeffrey A.; Elbert, Donald; Schoenmakers, Ronald, Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds.
Tomalia, Donald A.; Swanson, Douglas R.; Huang, Baohua; Pulgam, Veera Reddy, Dendritic polymers with enhanced amplification and interior functionality.
Tomalia, Donald A.; Swanson, Douglas R.; Huang, Baohua; Pulgam, Veera Reddy; Heinzelmann, Joseph R.; Svenson, Sonke; Reyna, Lori A.; Zhuravel, Michael A.; Chauhan, Abhay Singh; DeMattei, Cordell R., Dendritic polymers with enhanced amplification and interior functionality.
Spehar Edward R. (49 Orion Way Neshanic Station NJ 08853) Harkins Bernard F. (2000 Woodland Ave. S. Plainfield NJ 07080) Colin Laurence (Box 301 Cross River NY 10518), Dispensing mixer for the storage and mixing of separate materials.
Tiefenbrun Jonathan (62 Country Rd. Mamaronek NY 10543) Wilk Peter J. (185 W. End Ave. New York NY 10023), Instrument and associated method for applying biologically effective composition during laparoscopic operation.
Pittalis Francesco (Rome ITX) Bartoli Francesco (Rome ITX) Giovannoni Guido (S. Giuliano Milanese ITX), Process for the preparation of chitosan fibers.
Zuccato Alessandro,ITX ; Cella Gian Domenico,ITX ; Perego Gabriele,ITX, Process of surface activation of biocompatible and bioabsorbable aliphatic polyesters and polyesters thus activated.
Wallace Donald G. ; Cruise Gregory M. ; Rhee Woonza M. ; Schroeder Jacqueline Anne ; Coker ; III George T. ; Maroney Marcee M., Rapid gelling biocompatible polymer composition.
Wallace, Donald G.; Cruise, Gregory M.; Rhee, Woonza M.; Schroeder, Jacqueline Anne; Coker, III, George T.; Maroney, Marcee M.; Trollsas, Olof Mikael, Rapid-gelling biocompatible polymer composition and associated methods of preparation and use.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.