System for delivering therapeutic agents into living cells and cells nuclei
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-051/00
C07F-009/06
A61K-049/00
C07F-009/6561
C07J-051/00
C07F-009/09
C12N-015/87
C07H-021/00
C07F-009/24
A61K-047/48
A61K-048/00
A61K-031/66
A61K-031/661
출원번호
US-0690493
(2015-04-20)
등록번호
US-9556210
(2017-01-31)
발명자
/ 주소
Segev, David
출원인 / 주소
SABAG-RFA LTD.
대리인 / 주소
Cohen, Mark S.
인용정보
피인용 횟수 :
0인용 특허 :
27
초록▼
The present invention relates to a novel delivery system for delivering therapeutic agents into living cells, and more particularly, to novel chemical moieties that are designed capable of targeting and/or penetrating cells or other targets of interest and further capable of binding therapeutic agen
The present invention relates to a novel delivery system for delivering therapeutic agents into living cells, and more particularly, to novel chemical moieties that are designed capable of targeting and/or penetrating cells or other targets of interest and further capable of binding therapeutic agents to be delivered to these cells, and to delivery systems containing same.
대표청구항▼
1. A compound represented by the structure of formula XXX: whereinR1 and R2 are each independently selected from a C1-C6 linear or branched alkyl, C3-C7 cycloalkyl, or R1 and R2 are joined together to form a 4-7 membered heterocyclic ring;R3 is a C1-C6 linear or branched alkyl, CH3, CH2CH2CN, CH2CH2
1. A compound represented by the structure of formula XXX: whereinR1 and R2 are each independently selected from a C1-C6 linear or branched alkyl, C3-C7 cycloalkyl, or R1 and R2 are joined together to form a 4-7 membered heterocyclic ring;R3 is a C1-C6 linear or branched alkyl, CH3, CH2CH2CN, CH2CH2SO2Ar or CH2CH2SO2CH3;R4 is an alcohol protecting group, wherein said alcohol protecting group is: trityl (triphenylmethyl, Tr), Methoxytrityl [(4-methoxyphenyl)diphenylmethyl, MMT), Dimethoxytrityl [bis-(4-methoxyphenyl)phenylmethyl] (DMT), Acetyl (Ac), Benzoyl (Bz), Benzyl (Bn, Bul), β-Methoxyethoxymethyl ether (MEM), Methoxymethyl ether (MOM), p-Methoxybenzyl ether (PMB), Methylthiomethyl ether, Pivaloyl (Piv), Tetrahydropyranyl (THP), Silyl ether, methyl ether or ethoxyethyl ether;R5 is an amine protecting group, wherein said amine protecting group is: TFA (trifluoroacetamide), FMOC (9-Fluorenylmethyloxycarbonyl), FMS [(9H-Fluoren-9-yl)methanesulfonyl], acetyl (Ac) or benzoyl (Bz). 2. The compound of claim 1, wherein R1 and R2 are C1-C6 linear or branched alkyl. 3. The compound of claim 1, wherein R3 is CH2CH2CN. 4. The compound of claim 1, wherein R4 is Dimethoxytrityl [bis-(4-methoxyphenyl)phenylmethyl)] (DMT). 5. The compound of claim 1, wherein R5 is trifluoroacetamide (TFA). 6. The compound of claim 1, wherein said compound is represented by the following structure:
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