Intravascular functional element and method of manufacture
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61F-002/86
A61F-002/88
C23C-008/02
C23C-008/52
A61L-031/02
A61L-031/14
A61F-002/90
출원번호
US-0177470
(2014-02-11)
등록번호
US-9561120
(2017-02-07)
우선권정보
DE-10 2013 101 334 (2013-02-11)
발명자
/ 주소
Schüβler, Andreas
Siekmeyer, Gerd
Cattaneo, Giorgio
Mailänder, Werner
출원인 / 주소
ADMEDES INC.
대리인 / 주소
Shakir, Hassan Abbas
인용정보
피인용 횟수 :
0인용 특허 :
7
초록▼
The invention relates to a method of manufacture of an intravascular functional element that can be introduced into a hollow organ and that comprises at least one wire (10) of an alloy having nickel and titanium as alloying elements, with the following steps: preparation of a metal body of the wire
The invention relates to a method of manufacture of an intravascular functional element that can be introduced into a hollow organ and that comprises at least one wire (10) of an alloy having nickel and titanium as alloying elements, with the following steps: preparation of a metal body of the wire (10) with a metallic surface, then formation of a first oxide layer on the metallic surface of the metal body, then performance of a heat treatment of the wire (10) in a nitrogen-containing salt bath for thermal formation of a second mixed oxide layer on the first oxide layer, wherein the total layer thickness is 15 nm to 100 nm and the mixed oxide layer contains TiO2 and at least one nitride, especially titanium oxynitride and/or titanium nitride.
대표청구항▼
1. A method of manufacturing an intravascular functional element, the intravascular functional element for introduction into a hollow organ; the intravascular functional element comprising a wire comprising an alloy of nickel and titanium as alloying elements; anda mixed oxide layer formed on the su
1. A method of manufacturing an intravascular functional element, the intravascular functional element for introduction into a hollow organ; the intravascular functional element comprising a wire comprising an alloy of nickel and titanium as alloying elements; anda mixed oxide layer formed on the surface of the wire, the mixed oxide layer comprising a layer thickness from 15 nm to 100 nm,TiO2, anda nitride, the nitride being a titanium nitride or an titanium oxynitride,wherein the wire forms a wire structure comprising the wire;wherein the wire structure comprises a coil for aneurysm treatment or a braid;wherein the wire structure comprises a contact zone, the contact zone having a plurality of cross-overs of the wire where the wire crosses-over itself ora plurality of self-contact points of the wire where the wire contacts itself; andwherein the mixed oxide layer is homogeneous and has a substantially constant thickness on the wire even at cross-overs or self-contact points;the method comprising the steps of: (a) preparing a metal body of the wire;(b) subsequent to step (a), forming a first oxide layer on the surface of the wire; and(c) subsequent to step (b), heat treating the wire in a nitrogen-containing salt bath for thermal formation of the mixed oxide layer on the first oxide layer. 2. The method according to claim 1, wherein the layer thickness is at least 55 nm. 3. The method according to claim 1, wherein the layer thickness is at most 95 nm. 4. The method according to claim 1, wherein a peak of a oxygen concentration in the mixed oxide layer is formed as a plateau. 5. The method according to claim 4, wherein a ratio of intensities between nitrogen and oxygen comprises a range of 1:2.5 to 1:10 in the plateau, and decreases toward an interior of the wire, wherein the intensities are determined respectively by Auger electron spectroscopy (AES). 6. The method according to claim 1, wherein the nitride extends from an exterior surface of the mixed oxide layer to a depth in the wire of ⅔ of the total thickness of the mixed oxide layer. 7. The method according to claim 1, wherein the mixed oxide layer comprises nickel, the nickel in a region extending from an exterior surface of the mixed oxide layer to a depth of 30% of the total thickness of the mixed oxide layer is at most 6% by weight. 8. The method according to claim 1, further comprising a step of forming an enrichment of nickel oxide in an inner portion of the mixed oxide layer. 9. The method according to claim 1, further comprising a step of forming the contact zone of the wire prior to step (c). 10. The method according to claim 9, wherein the step of forming the contact zone of the wire is performed by braiding the wire. 11. The method according to claim 9, wherein the step of forming the contact zone of the wire is performed by winding the wire into a coil. 12. The method according to claim 1, wherein a contact angle measured with distilled water is smaller than 90° and at least 30°. 13. The method according to claim 1, wherein the salt bath comprises an alkali metal-nitrogen salt, a potassium nitrate, a sodium nitrite, or a mixture of potassium nitrate and sodium nitrite. 14. The method according to claim 13, wherein the content of potassium nitrate is greater than the content of sodium nitrite. 15. A method according to claim 13, wherein the salt bath comprises30-40 wt % KNO325-35 wt % NaNO2rest usual carbon compounds and impurities,wherein a content of potassium nitrate is greater than a content of sodium nitrite. 16. The method according to claim 1, wherein step (c) is performed after performing a step of introducing a functional item, the functional item being a radiologically visible markings, or after performing a step of joining process. 17. The method according to claim 1, wherein step (a) is performed by electro-polishing the wire. 18. An intravascular functional element for introduction into a hollow organ, the intravascular functional element comprises: a wire comprising an alloy of nickel and titanium as alloying elements; anda mixed oxide layer formed on the surface of the wire, the mixed oxide layer comprising a layer thickness from 15 nm to 100 nm,TiO2, anda nitride, the nitride being a titanium nitride or an titanium oxynitride;wherein the wire forms a wire structure comprising the wire;wherein the wire structure comprises a coil for aneurysm treatment or a braid;wherein the wire structure comprises a contact zone, the contact zone having a plurality of cross-overs of the wire where the wire crosses-over itself ora plurality of self-contact points of the wire where the wire contacts itself; andwherein the mixed oxide layer is homogeneous and has a substantially constant thickness on the wire even at cross-overs or self-contact points. 19. A functional element according to claim 18, wherein the mixed oxide layer is disposed in the contact zone. 20. A functional element according to claim 18, wherein the layer thickness is from 15 nm to 60 nm or is from 30 nm to 100 nm. 21. A functional element according to claim 18, wherein the wire structure is non-unitary. 22. A functional element according to claim 18, wherein a peak of a concentration of TiO2 in the mixed oxide layer forms a plateau. 23. A functional element according to claim 22, wherein a ratio of intensities between nitrogen and oxygen comprises a range of 1:2.5 to 1:10 in the plateau, and decreases toward an interior of the wire,wherein the intensities are determined respectively by Auger electron spectroscopy (AES). 24. A functional element according to claim 18, wherein the nitride extends from an exterior surface of the mixed oxide layer to a depth in the wire of ⅔ of the total thickness of the mixed oxide layer. 25. A functional element according to claim 18, wherein the mixed oxide layer comprises nickel, the nickel in a region extending from an exterior surface of the mixed oxide layer to a depth of 30% of the total thickness of the mixed oxide layer is at most 6% by weight. 26. A functional element according to claim 18, wherein an enrichment of nickel oxide is formed in an inner portion of the mixed oxide layer. 27. An intravascular functional element for introduction into a hollow organ, the intravascular functional element comprises: a plurality of wires comprising a first wire and a second wire, each wire comprising an alloy of nickel and titanium as alloying elements; anda mixed oxide layer formed on the surface of each wire, the mixed oxide layer comprising a layer thickness from 15 nm to 100 nm,TiO2, anda nitride, the nitride being a titanium nitride or an titanium oxynitride;wherein the plurality of wires form a non-unitary wire structure;wherein the wire structure comprises a coil for aneurysm treatment or a braid;wherein the wire structure comprising comprises a contact zone, the contact zone having a plurality of wire cross-overs where the first wire crosses-over the second wire ora plurality of wire self-contact point where the first wire contacts the second wire; andwherein the mixed oxide layer is homogeneous and has a substantially constant thickness of each wire even at wire cross-overs or wire self-contact points.
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