Device and implantation system for electrical stimulation of biological systems
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61N-001/36
A61B-005/03
A61N-001/05
A61B-005/145
출원번호
US-0500856
(2014-09-29)
등록번호
US-9561367
(2017-02-07)
발명자
/ 주소
Sharma, Virender K.
Gani, Matt Joseph
Goode, Paul V.
Hogg, Bevil
Miazga, Jay
Policker, Shai
출원인 / 주소
EndoStim, Inc.
대리인 / 주소
Novel IP
인용정보
피인용 횟수 :
0인용 특허 :
144
초록▼
The present specification discloses devices and methodologies for the treatment of transient lower esophageal sphincter relaxations (tLESRs). Individuals with tLESRs may be treated by implanting a stimulation device within the patient's lower esophageal sphincter and applying electrical stimulation
The present specification discloses devices and methodologies for the treatment of transient lower esophageal sphincter relaxations (tLESRs). Individuals with tLESRs may be treated by implanting a stimulation device within the patient's lower esophageal sphincter and applying electrical stimulation to the patient's lower esophageal sphincter, in accordance with certain predefined protocols. The presently disclosed devices have a simplified design because they do not require sensing systems capable of sensing when a person is engaged in a wet swallow and have improved energy storage requirements.
대표청구항▼
1. A method of treating a patient with gastrointestinal reflux disease comprising: implanting an electrical stimulator comprising an energy storage component, a non-volatile memory for storing programmatic code, and a pulse generator in electrical communication with at least one electrode, wherein s
1. A method of treating a patient with gastrointestinal reflux disease comprising: implanting an electrical stimulator comprising an energy storage component, a non-volatile memory for storing programmatic code, and a pulse generator in electrical communication with at least one electrode, wherein said electrode is implanted such that said electrode is configured to be in electrical communication with a lower esophageal sphincter (LES) of the patient; andprogramming said implanted electrical stimulator, wherein said electrical stimulator is programmed such that, when operated, the electrical stimulator generates a pulse stream, wherein said pulse stream comprises a pulse width having a range of 30 μsec to 5 msec, a pulse amplitude having a range of 2 to 15 mAmp, and a pulse frequency having a range of 2 to 80 Hz, wherein values for each of said pulse width, pulse amplitude, and pulse frequency are defined such that swallowing of the patient is not hindered by said stimulation while said stimulation is occurring. 2. The method of claim 1, wherein the electrical stimulator comprises an accelerometer. 3. The method of claim 2, further comprising programming the electrical stimulator to have a stimulation mode adapted to automatically stimulate the LES during time periods in which the patient is in a supine position as determined by said accelerometer. 4. The method of claim 3, wherein said supine position is defined by a level of inclination relative to a vertical baseline and wherein said level is programmable and has a range of 50 to 80 degrees. 5. The method of claim 3, further comprising programming the electrical stimulator such that said automatic stimulation occurs after the patient has been in the supine position for a predetermined period of time and wherein said predetermined period of time has a range of 1 minute to 60 minutes. 6. The method of claim 3, further comprising programming the electrical stimulator such that said automatic stimulation occurs after a minimum percentage of data points occur within a predetermined period of time. 7. The method of claim 1, wherein said electrical stimulator is not in communication with a sensor to determine when the patient is swallowing and does not modify said pulse stream based on said swallowing. 8. A method of treating a patient with gastrointestinal reflux disease comprising: implanting an electrical stimulator comprising an energy storage component, an accelerometer, a non-volatile memory for storing programmatic code, and a pulse generator in electrical communication with at least one electrode, wherein said electrode is implanted such that said electrode is configured to be in electrical communication with a lower esophageal sphincter (LES) of the patient; andprogramming said implanted electrical stimulator, wherein said electrical stimulator is programmed such that, when operated, the electrical stimulator generates a pulse stream, wherein said pulse stream comprises a pulse width having a range of 30 μsec to 5 msec, a pulse amplitude having a range of 2 to 15 mAmp, and a pulse frequency having a range of 2 to 80 Hz, wherein values for each of said pulse width, pulse amplitude, and pulse frequency are defined such that swallowing of the patient is not hindered by said stimulation while said stimulation is occurring. 9. The method of claim 8, further comprising programming the electrical stimulator to automatically stimulate the LES based on whether the patient is in a supine position, as determined by data from said accelerometer. 10. The method of claim 9, wherein said supine position is defined by a level of inclination relative to a vertical baseline and wherein said level is programmable and has a range of 50 to 80 degrees. 11. The method of claim 9, further comprising programming the electrical stimulator such that automatic stimulation occurs after the patient has been in the supine position for a predetermined period of time and wherein said predetermined period of time has a range of 1 minute to 60 minutes. 12. The method of claim 9, further comprising programming the electrical stimulator such that automatic stimulation occurs after a minimum percentage of data points occur within a predetermined period of time.
연구과제 타임라인
LOADING...
LOADING...
LOADING...
LOADING...
LOADING...
이 특허에 인용된 특허 (144)
Wesselink, Wilbert A., Activity sensing for stimulator control.
Stuebe Thomas D. (Littleton CO) Helmstetter Paul M. (Littleton CO) Clark Charles S. (Littleton CO), Apparatus and method for ambulatory reflux monitoring.
Boveja, Birinder R., Apparatus and method for neuromodulation therapy for obesity and compulsive eating disorders using an implantable lead-receiver and an external stimulator.
Boveja, Birinder R., Apparatus and method for treatment of neurological and neuropsychiatric disorders using programmerless implantable pulse generator system.
Sharma, Virender K.; Gani, Matt Joseph; Goode, Paul V.; Hogg, Bevil; Miazga, Jay; Policker, Shai; Raby, Kaila, Device and implantation system for electrical stimulation of biological systems.
Sharma, Virender K.; Gani, Matthew Joseph; Goode, Paul V.; Hogg, Bevil; Miazga, Jay; Policker, Shai; Raby, Kaila, Device and implantation system for electrical stimulation of biological systems.
Sharma, Virender K.; Gani, Matthew Joseph; Goode, Paul V.; Hogg, Bevil; Miazga, Jay; Policker, Shai; Raby, Kaila, Device and implantation system for electrical stimulation of biological systems.
Sharma, Virender K.; Gani, Matthew Joseph; Goode, Paul V.; Hogg, Bevil; Miazga, Jay; Policker, Shai; Raby, Kaila, Device and implantation system for electrical stimulation of biological systems.
Sharma, Virender K.; Gani, Matthew Joseph; Goode, Paul V.; Hogg, Bevil; Miazga, Jay; Policker, Shai; Raby, Kalia, Device and implantation system for electrical stimulation of biological systems.
Sharma, Virender K.; Sofer, Edy; Goode, Paul V.; Hogg, Bevil; Policker, Shai; Gani, Matthew Joseph; Miazga, Jay; Raby, Kaila, Device and implantation system for electrical stimulation of biological systems.
Pasricha Pankaj J. (Columbia MD) Kalloo Anthony N. (Glenndale MD), Device for treating gastrointestinal muscle disorders and other smooth muscle dysfunction.
Boveja, Birinder R., External pulse generator for adjunct (add-on) treatment of obesity, eating disorders, neurological, neuropsychiatric, and urological disorders.
Roline, Glenn M.; Terry, Michael B.; Roberts, Jonathan P.; Reinke, James D.; Corey, Robert A., Fault tolerant implantable pulse generators and implantable cardioverter-defibrillators incorporating physiologic sensors and methods for implementing fault tolerance in same.
Whitehurst,Todd K; McGivern,James P; Mann,Carla M, Fully implantable neurostimulator for autonomic nerve fiber stimulation as a therapy for urinary and bowel dysfunction.
Dinsmoor, David A.; Starkebaum, Warren L., Gastro-electric stimulation for increasing the acidity of gastric secretions or increasing the amounts thereof.
Chen Jian Dez (Edmond OK) McCallum Richard W. (Charlottesville VA) Williams Ronald (Charlottesville VA) Ross Robert (Charlottesville VA) Lin Zhiyue (Charlottesville VA) Tillack Jonathan (Charlottesvi, Gastro-intestinal pacemaker having phased multi-point stimulation.
Houben,Richard P. M.; Christopherson,Mark A.; Donders,Adrianus P.; Leinders,Robert; Deno,Curtis D., Implantable lead-based sensor powered by piezoelectric transformer.
Schulman Joseph H. (Santa Clarita CA) Loeb Gerald E. (Kingston CAX) Gord John C. (Venice CA) Strojnik Primoz (Granada Hills CA), Implantable microstimulator.
Strother, Robert B.; Mrva, Joseph J.; Thrope, Geoffrey B., Implantable pulse generator for providing functional and/or therapeutic stimulation of muscles and/or nerves and/or central nervous system tissue.
Foley, Stephen T., Method and apparatus for intentional impairment of gastric motility and/or efficiency by triggered electrical stimulation of the gastrointestinal tract with respect to the intrinsic gastric electrical activity.
DiLorenzo, Daniel John, Method and apparatus for neuromodulation and physiologic modulation for the treatment of metabolic and neuropsychiatric disease.
Chachques Juan C. (Savigny Sur Orge FRX) Grandjean Pierre A. (Heerlen NLX) Smits Karel (Oirsbeek NLX), Method and apparatus including a sliding insulation lead for cardiac assistance.
Knudson, Mark B.; Wilson, Richard R.; Tweden, Katherine S.; Conrad, Timothy R., Nerve stimulation and blocking for treatment of gastrointestinal disorders.
Douglas Donald D. (2009 Madison Ave. Lewisburg PA 17837), Percutaneously placed electrical gastrointestinal pacemaker stimulatory system, sensing system, and pH monitoring system.
Torgerson Nathan A. ; Prather Jean E. ; Forsberg John W. ; Kinghorn Curtis D., Portable stimulation screening device for screening therapeutic effect of electrical stimulation on a patient user duri.
Cigaina Valerio (Via 4 Novembre 3a 31050 Villorba (Treviso) ITX), Process and device for treating obesity and syndromes related to motor disorders of the stomach of a patient.
Goetz, Steven M.; Stone, Richard T.; Ball, Warren W.; Wahlstrand, Carl D., Programming interface with a concentric axial view of a stimulation lead with complex electrode array geometry.
Goetz, Steven M.; Stone, Richard T.; Ball, Warren W.; Wahlstrand, Carl D., Programming interface with a cross-sectional view of a stimulation lead with complex electrode array geometry.
Goetz, Steven M.; Houchins, Andrew H.; Keacher, Jeffrey T.; King, Gary W.; Heruth, Kenneth T.; Testerman, Roy L.; Lee, Michael T.; Torgerson, Nathan A.; Nolan, Joseph J., Shifting between electrode combinations in electrical stimulation device.
Boveja,Birinder R.; Widhany,Angely R., System and method for providing electrical pulses to the vagus nerve(s) to provide therapy for obesity, eating disorders, neurological and neuropsychiatric disorders with a stimulator, comprising bi-directional communication and network capabilities.
Soffer, Edy E.; Conklin, Jeffrey, Systems and methods for electrically stimulating the lower esophageal sphincter to treat gastroesophageal reflux disease.
Buschman, Hendrik Peter Johan; Burnes, John Edward; Cornelussen, Richard N. M.; Hill, Michael Roland Scott; Kornet, Lilian; Ordelman, Simone Cornelia Maria Anna; Veltink, Petrus Hermanus, Therapy using perturbation and effect of physiological systems.
Buschman, Hendrik Peter Johan; Burnes, John Edward; Cornelussen, Richard N. M.; Hill, Michael Roland Scott; Kornet, Lilian; Ordelman, Simone Cornelia Maria Anna; Veltink, Petrus Hermanus, Therapy using perturbation and effect of physiological systems.
Wernicke Joachim F. (League City TX) Terry ; Jr. Reese S. (Houston TX) Baker ; Jr. Ross G. (Houston TX), Treatment of eating disorders by nerve stimulation.
Wernicke Joachim F. (League City TX) Terry ; Jr. Reese S. (Houston TX) Baker ; Jr. Ross G. (Houston TX), Treatment of eating disorders by nerve stimulation.
Terry ; Jr. Reese S. (Houston TX) Baker ; Jr. Ross G. (Houston TX) Marquette Andre (Stamford CT), Treatment of motility disorders by nerve stimulation.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.