[특허]Fluidics device allowing fluid flow between a plurality of wells

SciKon Innovation, Inc.

검색어에 아래의 연산자를 사용하시면 더 정확한 검색결과를 얻을 수 있습니다.
검색연산자

검색도움말
검색연산자	기능	검색시 예
()	우선순위가 가장 높은 연산자	예1) (나노 (기계 \| machine))
공백	두 개의 검색어(식)을 모두 포함하고 있는 문서 검색	예1) (나노 기계) 예2) 나노 장영실
\|	두 개의 검색어(식) 중 하나 이상 포함하고 있는 문서 검색	예1) (줄기세포 \| 면역) 예2) 줄기세포 \| 장영실
!	NOT 이후에 있는 검색어가 포함된 문서는 제외	예1) (황금 !백금) 예2) !image
*	검색어의 *란에 0개 이상의 임의의 문자가 포함된 문서 검색	예) semi*
""	따옴표 내의 구문과 완전히 일치하는 문서만 검색	예) "Transform and Quantization"

과학기술 지식인프라 ScienceON

연합인증

연합인증 가입 기관의 연구자들은 소속기관의 인증정보(ID와 암호)를 이용해 다른 대학, 연구기관, 서비스 공급자의 다양한 온라인 자원과 연구 데이터를 이용할 수 있습니다.

이는 여행자가 자국에서 발행 받은 여권으로 세계 각국을 자유롭게 여행할 수 있는 것과 같습니다.

연합인증으로 이용이 가능한 서비스는 NTIS, DataON, Edison, Kafe, Webinar 등이 있습니다.

한번의 인증절차만으로 연합인증 가입 서비스에 추가 로그인 없이 이용이 가능합니다.

다만, 연합인증을 위해서는 최초 1회만 인증 절차가 필요합니다. (회원이 아닐 경우 회원 가입이 필요합니다.)

연합인증 절차는 다음과 같습니다.

최초이용시에는
ScienceON에 로그인 → 연합인증 서비스 접속 → 로그인 (본인 확인 또는 회원가입) → 서비스 이용

그 이후에는
ScienceON 로그인 → 연합인증 서비스 접속 → 서비스 이용

연합인증을 활용하시면 KISTI가 제공하는 다양한 서비스를 편리하게 이용하실 수 있습니다.

특허 상세정보

MyON담기

내보내기 페이스북 공유 트위터 공유 카카오톡 공유

Fluidics device allowing fluid flow between a plurality of wells

특허상세정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	B01L-003/00 C12M-001/26 C12M-001/12 C12M-001/32
출원번호	US-0016913 (2013-09-03)
등록번호	US-9573128 (2017-02-21)
발명자 / 주소	McClelland, Randall
출원인 / 주소	SciKon Innovation, Inc.
대리인 / 주소	NK Patent Law, PLLC
인용정보	피인용 횟수 : 0 인용 특허 : 45

초록
▼

Disclosed are fluidics devices and assemblies allowing for fluid flow between a plurality of wells. The fluidics devices and assemblies that are provided mimic in vivo tissue environments by allowing for initially segregated tissue cultures that can then be linked through fluid flow to measure integrated tissue response. The devices and assemblies provide a pumpless system using surface tension, gravity, and channel geometries. By linking human tissue functional systems to better simulate in vivo feedback and response signals between the tissues, the nee...

대표
청구항
▼

1. A fluidics device comprising: a unitarily constructed tray configured to rest on a substantially flat surface including: a dosing well positioned upstream from a plurality of wells aligned in a row for containing a respective host fluid,wherein each of the plurality of wells defines a cavity having a bottom surface, a wall surface extending from the bottom surface and an open side defined by a circumference of the wall surface,wherein, when the tray rests on the flat surface, each of the open sides is in a step-down position relative to the open side of each adjacent upstream well and the wall surface is substantially perpendicular to the flat surface; andone or more channels extending between the open side of adjacent upstream wells and the open side of the adjacent downstream wells to define a channel fluid flow path there between. 2. The fluidics device of claim 1, further comprising a wick downstream from at least a portion of the plurality of wells and in fluid contact with the channel fluid flow path for regulating fluid flow through the plurality of wells. 3. The fluidics device of claim 2, wherein the device and/or the wick comprises one of a polymer, a synthetic polymer, a biodegradable polymer, a plastic, a biodegradable plastic, a thermoplastic, a polystyrene, a polyethylene, a polypropylene, a polyvinyl chloride, a polytetrafluoroethylene, a silicone, a glass, a PYREX, a borosilicate, and combinations thereof. 4. The fluidics device of claim 2, wherein the wick regulates fluid flow through the plurality of wells at a rate ranging from 0.0007 ml/min to 30 ml/min. 5. The fluidics device of claim 1, further comprising a collection well downstream from the plurality of wells to collect the respective host fluid after having flowed through the plurality of wells. 6. The fluidics device of claim 5, further comprising a wick contained in the collection well and the wick in fluid contact with the channel fluid flow path for regulating fluid flow through the plurality of wells. 7. The fluidics device of claim 6, wherein the wick is carried by a shoulder or by one or more posts defined by the collection well such that the wick does not contact a bottom surface of the collection well. 8. The fluidics device of claim 7, wherein the wick defines a gap such that only a portion of an edge of the wick is in fluid contact with the channel fluid flow path. 9. The fluidics device of claim 1, further comprising a dosing well channel extending from a bottom of the dosing well to the channel fluid flow path such that the dosing fluid flows to the respective host fluid of the adjacent downstream well through the dosing well channel and along the channel fluid flow path. 10. The fluidics device of claim 9, further comprising a dosing well channel cover configured to enclose the dosing well channel. 11. The fluidics device of claim 10, wherein the dosing well channel cover comprises one of a polymer, a synthetic polymer, a biodegradable polymer, a plastic, a biodegradable plastic, a thermoplastic, a polystyrene, a polyethylene, a polypropylene, a polyvinyl chloride, a polytetrafluoroethylene, a silicone, a glass, a PYREX, a borosilicate, and combinations thereof. 12. The fluidics device of claim 1, wherein a side of the dosing well defines an angle of greater than 90° extending from a bottom of the dosing well up to the channel fluid flow path of the adjacent well. 13. The fluidics device of claim 5, wherein the collection well has a floor defining a divot, wherein the floor is angled such that the divot is defined at a lower portion of the floor. 14. The fluidics device of claim 5, further comprising a collection well channel extending from the channel fluid flow path to a bottom of the collection well such that the respective host fluid of the adjacent upstream well flows along the channel fluid flow path and through the collection well channel into the collection well. 15. The fluidics device of claim 1, wherein the one or more channels has a width ranging from 10 to 3500 microns and a depth of 10 to 1500 microns. 16. The fluidics device of claim 1, wherein the one or more channels defines a triangular-shape extending between each of the adjacent wells and generally converging at each adjacent downstream well. 17. The fluidics device of claim 16, further comprising 2, 3, or 4 microchannels contiguous with the triangular-shape channel, and each of the microchannels having a width ranging from 200 to 750 microns and a depth of 10 to 1500 microns. 18. The fluidics device of claim 1, further comprising a channel cover configured for engagement on top of the one or more channels extending between the adjacent wells to enclose the channel. 19. The fluidics device of claim 18, wherein the channel cover comprises one of a polymer, a synthetic polymer, a biodegradable polymer, a plastic, a biodegradable plastic, a thermoplastic, a polystyrene, a polyethylene, a polypropylene, a polyvinyl chloride, a polytetrafluoroethylene, a silicone, a glass, a PYREX, a borosilicate, and combinations thereof. 20. The fluidics device of claim 1, comprising 12 wells in a respective row and a total of 8 rows. 21. The fluidics device of claim 1, wherein the plurality of wells contain a respective cell culture such that an effect on the cells of coming into contact with the dosing fluid can be measured. 22. The fluidics device of claim 21, wherein the respective cell culture is a stem cell culture or a progenitor cell culture. 23. The fluidics device of claim 1, wherein a surface of one or more of the plurality of wells is modified with one or both of a chemical layer and a protein layer to support a cell culture. 24. The fluidics device of claim 23, wherein the protein layer comprises one of collagen I, collagen II, collagen III, laminin, fibronection, and combinations thereof. 25. The fluidics device of claim 1, wherein the cavity of each of the downstream wells defines a substantially same volume and the bottom surface of each of the downstream wells defines a substantially same thickness. 26. The fluidics device of claim 1, wherein a dosing fluid deposited into the dosing well flows to the respective host fluid of the adjacent downstream well along the channel fluid flow path there between, and the respective host fluid subsequently flows to each adjacent downstream well along the channel fluid flow path there between. 27. An assembly for allowing fluid flow between a plurality of wells comprising: a first fluidics device comprising: a dosing well positioned upstream from a plurality of wells aligned in a row for containing a respective host fluid,wherein each of the plurality of wells defines a cavity having a bottom surface a wall surface extending from the bottom surface and an open side defined by a circumference of the wall surface,wherein each of the open sides is in a step-down position relative to the open side of each adjacent upstream well; andone or more channels extending between the open side of adjacent upstream wells and the open side of the adjacent downstream wells to define a channel fluid flow path there between; anda reservoir tray configured for nesting engagement on top of the first fluidics device, the reservoir tray comprising: at least one chamber for containing a respective chamber fluid; anda reservoir aperture defined in a floor of the at least one chamber and configured such that the reservoir aperture is positioned above the dosing well of the first fluidics device when in nesting engagement with the first fluidics device, wherein the floor of the at least one chamber is angled and the reservoir aperture is defined at a lower portion of the floor of the at least one chamber such that the chamber fluid flows through the reservoir aperture into the dosing well of the first fluidics device when the reservoir tray and the first fluidics device are nestably engaged. 28. The assembly of claim 27, further comprising a cover tray configured for nesting engagement on top of the reservoir tray or the first fluidics device. 29. The assembly of claim 27, wherein the first fluidics device comprises: a collection well downstream from the plurality of wells to collect the respective host fluid after its having flowed through the plurality of wells, wherein the collection well defines a collection aperture; anda second reservoir tray comprising at least one chamber for containing a respective chamber fluid and configured for nesting engagement underneath the first fluidics device such that fluid from the collection well of the first fluidics device flows through the collection aperture into the chamber of the second reservoir tray when the second reservoir tray and the first fluidics device are nestably engaged. 30. The assembly of claim 27, further comprising a second fluidics device configured for nesting engagement underneath the first fluidics device, wherein the first fluidics device comprises a collection well downstream from the plurality of wells to collect the respective host fluid after its having flowed through the plurality of wells, and wherein the collection well defines a collection aperture such that fluid from the collection well flows through the collection aperture into the dosing well of the second fluidics device when the first and second fluidics devices are nestably engaged. 31. The assembly of claim 30, further comprising one or more additional fluidics devices configured for nesting engagement underneath the second fluidics device, wherein the one or more additional fluidics devices each comprise an additional collection well downstream from a respective plurality of wells to collect the respective host fluid after its having flowed through the respective plurality of wells, and the additional collection well of each of the one or more additional fluidics device defines an additional aperture such that fluid from the additional collection well flows through the additional aperture into the dosing well of another one of the one or more additional fluidics device positioned underneath when the one or more additional fluidics devices are nestably engaged with the second fluidics device. 32. The fluidics device of claim 27, wherein the cavity of each of the downstream wells defines a substantially same volume and the bottom surface of each of the downstream wells defines a substantially same thickness. 33. The assembly of claim 27, wherein a dosing fluid deposited into the dosing well flows to the respective host fluid of the adjacent downstream well along the channel fluid flow path there between, and the respective host fluid subsequently flows to each adjacent downstream well along the channel fluid flow path there between.

이 특허에 인용된 특허 (45)

IPC 상위 출원인

내보내기

상세정보
내보내기 구분	파일저장 인쇄 메일전송
구성항목	관리번호, 국가코드, 자료구분, 상태, 출원번호, 출원일자, 공개번호, 공개일자, 등록번호, 등록일자, 발명명칭(한글), 발명명칭(영문), 출원인(한글), 출원인(영문), 출원인코드, 대표IPC 관리번호, 국가코드, 자료구분, 상태, 출원번호, 출원일자, 공개번호, 공개일자, 공고번호, 공고일자, 등록번호, 등록일자, 발명명칭(한글), 발명명칭(영문), 출원인(한글), 출원인(영문), 출원인코드, 대표출원인, 출원인국적, 출원인주소, 발명자, 발명자E, 발명자코드, 발명자주소, 발명자 우편번호, 발명자국적, 대표IPC, IPC코드, 요약, 미국특허분류, 대리인주소, 대리인코드, 대리인(한글), 대리인(영문), 국제공개일자, 국제공개번호, 국제출원일자, 국제출원번호, 우선권, 우선권주장일, 우선권국가, 우선권출원번호, 원출원일자, 원출원번호, 지정국, Citing Patents, Cited Patents
저장형식	Text(ASCII format) Excel format PIAS분석(.xls)
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	> 총 건의 자료가 검색되었습니다. > 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) > 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. > 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) > 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오 > ~ > Text(ASCII format) Excel format

과학기술 지식인프라 ScienceON

ScienceON Chatbot

연합인증

특허 상세정보

Fluidics device allowing fluid flow between a plurality of wells

초록
▼

대표
청구항
▼

이 특허에 인용된 특허 (45)

IPC 상위 출원인

과제정보

상세정보조회

원문조회

IPC 상세정보(version : 201201)

연구과제 성과물(0)

참여연구원의 다른 문헌(0)

처리중입니다.

잠시만 기다려주세요.

ScienceON Chatbot

연합인증

특허 상세정보

Fluidics device allowing fluid flow between a plurality of wells

초록 ▼

대표청구항 ▼

이 특허에 인용된 특허 (45)

IPC 상위 출원인

과제정보

상세정보조회

원문조회

IPC 상세정보(version : 201201)

연구과제 성과물(0)

참여연구원의 다른 문헌(0)

처리중입니다.

잠시만 기다려주세요.

초록
▼

대표
청구항
▼