Antimicrobial housing and cover for a medical device
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
C08J-009/36
A61L-027/34
A61L-027/50
A61L-027/54
A61L-029/08
A61L-029/14
A61L-029/16
A61L-031/10
A61L-031/14
A61L-031/16
C07D-213/30
A61M-039/04
A61M-039/16
출원번호
US-0802528
(2015-07-17)
등록번호
US-9574060
(2017-02-21)
발명자
/ 주소
Bui, Tuan
Hai, Ton That
Nordhaus, Mark
Sanders, Paul
Jiang, Cong
Lamb, David
Yardimci, Ozlem
Lurvey, Kent L.
Krongauz, Vadim V.
출원인 / 주소
Baxter International Inc.
대리인 / 주소
K&L Gates LLP
인용정보
피인용 횟수 :
0인용 특허 :
65
초록▼
A method for immobilizing dyes and antimicrobial agents on a polymeric cover or housing for a medical device is disclosed and described. The surface may be that of a catheter, a connector, a drug vial spike, a bag spike, a prosthetic device, an endoscope, a surface of an infusion pump, a key pad, a
A method for immobilizing dyes and antimicrobial agents on a polymeric cover or housing for a medical device is disclosed and described. The surface may be that of a catheter, a connector, a drug vial spike, a bag spike, a prosthetic device, an endoscope, a surface of an infusion pump, a key pad, a touch screen or a handle. The surfaces may also be one or more of those associated with a infusion of a medicament or dialysis treatment, such as peritoneal dialysis or hemodialysis, where it is important that the working surface for the dialysis fluid be sterile. These surfaces include connectors for peritoneal dialysis sets or for hemodialysis sets, bag spikes, dialysis catheters, and so forth. A method for determining whether a surface has been sterilized, and a dye useful in so indicating, is also disclosed.
대표청구항▼
1. A polymeric housing for a medical device comprising: a polymer;a plurality of attachment sites on at least an outer surface of the polymer;a plurality of functional groups attached to the attachment sites; anda solvatochromic dye attached to the functional groups, wherein the solvatochromic dye c
1. A polymeric housing for a medical device comprising: a polymer;a plurality of attachment sites on at least an outer surface of the polymer;a plurality of functional groups attached to the attachment sites; anda solvatochromic dye attached to the functional groups, wherein the solvatochromic dye comprises 4,6-dichloro-2-[2-(6-aminohexyl-4-pyridinio)-vinyl]phenolate, and wherein the outer surface is configured to reversibly change from a first appearance to a second appearance when the outer surface is swabbed with a disinfecting solution. 2. The polymeric housing for the medical device according to claim 1, wherein the medical device is selected from the group consisting of a catheter, a drug vial spike, a connector, a vascular access device, a luer access device, an access port, a medication port, a pigtail connector, a prosthetic, an endoscope, a bronchoscope, a stethoscope, an infusion pump. 3. The polymeric housing for the medical device according to claim 1, wherein the polymer is porous and has an index of refraction from about 1.25 to about 1.6. 4. The polymeric housing for the medical device according to claim 1, wherein the polymer is selected from the group consisting of a discrete membrane, a foamed article, a thin film, a casting, a molding, and a coating. 5. The polymeric housing for the medical device according to claim 1 comprising an effective amount of a compound selected from the group consisting of chlorhexidine and its salts, an antimicrobial agent bearing an aminoalkyl group, chloroxyphenol, triclosan, triclocarban, chitosan, and a quaternary ammonium compound. 6. The polymeric housing for the medical device according to claim 1 comprising an effective amount of a material selected from the group consisting of an oligodynamic compound and an antimicrobial compound. 7. A polymeric housing for a medical device comprising: a porous polymeric surface;a plurality of attachment sites on the porous polymeric surface;a plurality of functional groups attached to the attachment sites;a solvatochromic dye directly attached to the functional groups, wherein the solvatochromic dye comprises 4,6-dichloro-2-[2-(6-aminohexyl-4-pyridinio)-vinyl]phenolate, and wherein the porous polymeric surface is configured to reversibly change from a first appearance to a second appearance when the porous polymeric surface is swabbed with a disinfecting solution; andan antimicrobial compound directly attached to the functional groups, wherein the antimicrobial compound is configured to be cidal to, or to resist growth of, microorganisms on the porous polymeric surface. 8. The polymeric housing for the medical device according to claim 7, wherein the medical device is selected from the group consisting of a catheter, a drug vial spike, a connector, a vascular access device, a luer access device, an access port, a medication port, a pigtail connector, a prosthetic, an endoscope, a bronchoscope, a stethoscope, an infusion pump. 9. The polymeric housing for the medical device according to claim 7, wherein the porous polymeric surface has an index of refraction from about 1.25 to about 1.6. 10. The polymeric housing for the medical device of claim 7, wherein the polymer is selected from the group consisting of elastomers, acrylic, COC, nylon, methacrylic, polycarbonate, ABS, polyurethane, polyester, and vinylester. 11. The polymeric housing for the medical device according to claim 7, wherein the attachment sites comprise at least one of carboxyl groups, amine groups, and amide groups. 12. The polymeric housing for the medical device according to claim 7, wherein the polymer is selected from a group consisting of a discrete membrane cut from a sheet, a foamed article, a film, a casting, a molding, and a coating. 13. The polymeric housing for the medical device according to claim 7, wherein the antimicrobial compound comprises an effective amount of a compound selected from the group consisting of chlorhexidine and its salts, an antimicrobial agent bearing an aminoalkyl group, chloroxyphenol, triclosan, triclocarban, chitosan, and a quaternary ammonium compound. 14. The polymeric housing for the medical device according to claim 7, wherein the porous polymeric surface further comprises an effective amount of a material selected from the group consisting of an oligodynamic compound and an antimicrobial compound. 15. A polymeric housing for a medical device comprising: a polymer comprising a porous surface;a plurality of attachment sites on a surface of the polymer;a plurality of functional groups attached to the attachment sites;a solvatochromic dye directly attached to the functional groups, wherein the solvatochromic dye comprises 4,6-dichloro-2-[2-(6-aminohexyl-4-pyridinio)-vinyl]phenolate, and wherein the porous surface is configured to reversibly change from a first appearance to a second appearance when the porous surface is swabbed with a disinfecting solution; andan amino-alkyl containing compound selected from the group consisting of peptides, proteins, Factor VIII or other anti-clotting Factor, polysaccharides, polymyxins, hyaluronic acid, heparin, condroitin sulfate, and chitosan directly attached to the attachment sites. 16. The polymeric housing for the medical device according to claim 15, further comprising an antimicrobial compound, attached to the attachment sites or to the functional groups, wherein the antimicrobial compound is configured to be cidal to, or to resist growth of, microorganisms on the porous surface. 17. The polymeric housing for the medical device according to claim 15, wherein the medical device is selected from the group consisting of a catheter, a drug vial spike, a connector, a vascular access device, a luer access device, an access port, a medication port, a pigtail connector, a prosthetic, an endoscope, a bronchoscope, a stethoscope, an infusion pump.
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