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Small molecule xanthine oxidase inhibitors and methods of use 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-031/11
  • C07C-205/44
  • A61K-031/185
  • A61K-031/277
  • A61K-045/06
  • C07C-255/56
  • C07C-309/44
  • C07C-317/22
  • A61K-031/519
  • C07C-047/544
  • C07C-047/565
  • C07C-255/57
  • C07C-047/54
  • C07C-313/04
  • A61K-009/00
출원번호 US-0483072 (2014-09-10)
등록번호 US-9585847 (2017-03-07)
발명자 / 주소
  • Chen, Changyi
  • Lu, Jian-Ming
  • Yao, Qizhi
출원인 / 주소
  • Baylor College of Medicine
대리인 / 주소
    Foley & Lardner LLP
인용정보 피인용 횟수 : 0  인용 특허 : 74

초록

Small molecule xanthine oxidase inhibitors are provided, as well as methods for their use in treating gout or hyperuricemia.

대표청구항

1. A method for reducing uric acid production in a subject comprising administering to the subject an effective amount of a, compound selected from the group consisting of: or a pharmaceutically acceptable salt thereof. 2. The method of claim 1, wherein the compound is administered orally.

이 특허에 인용된 특허 (74)

  1. Biftu Tesfaye (Parlin NJ) Ponpipom Mitree M. (Branchburg NJ) Girotra Nirindar N. (Old Bridge NJ), 2,5-diaryl tetrahydrofurans and analogs thereof as PAF antagonists.
  2. Baldwin John J. (Lansdale PA) Novello Frederick C. (Berwyn PA), 2-Pyrazinyl-trifluoromethylimidazoles and a method for their preparation.
  3. Kondo Shiro (Hachioji JPX) Fukushima Hisashi (Hino JPX) Hasegawa Masaichi (Hino JPX) Tsuchimoto Masahiro (Hino JPX) Nagata Ikuo (Hino JPX) Osada Yoshio (Hino JPX) Komoriya Keiji (Hachioji JPX) Yamagu, 2-arylthiazole derivatives and pharmaceutical composition thereof.
  4. McCombie Stuart W. (Caldwell NJ), 3-Substituted-1-aryl-2(1H)-quinolones useful as anti-allergy and anti-inflammatory agents.
  5. McCombie Stuart W. (Caldwell NJ), 3-substituted-1-aryl-2(H)-quinolones and their pharmaceutical compositions.
  6. Bacon Edward R. ; Singh Baldev, 6-aryl pyrazolo [3,4-d] pyrimidin-4-ones and compositions and methods of use thereof.
  7. Bacon Edward R. ; Singh Baldev, 6-aryl pyrazolo[3,4-D] pyrimidin-4-ones and compositions and method of use thereof.
  8. Oku Teruo,JPX ; Kayakiri Hiroshi,JPX ; Satoh Shigeki,JPX ; Abe Yoshito,JPX ; Sawada Yuki,JPX ; Inoue Takayuki,JPX ; Tanaka Hirokazu,JPX, 8-substituted quinazolines, quinoxalines and benzopyridazines.
  9. Bundgaard Hans (Horsholm DKX) Falch Erik (Vedbaek DKX), Acyl- or acyloxymethyl-allopurinol prodrugs.
  10. Hemmi Keiji (Tsukuba JPX) Neya Masahiro (Tsuchiura JPX) Marusawa Hiroshi (Yokohama JPX) Watanabe Shinya (Tsuchiura JPX) Hashimoto Masashi (Toride JPX), Amino acid derivatives, a process for the preparation thereof and pharmaceutical composition comprising the same.
  11. Or Yat Sun (Libertyville IL) Luly Jay R. (Libertyville IL), Anaphylatoxin receptor ligands containing lipophilic residues.
  12. Bavetsias Vassilios,GB2 ; Boyle Francis Thomas,GB2 ; Hennequin Laurent Francois Andre,FRX ; Marriott Jonathan Hugh,GB2, Anti-cancer compounds.
  13. Brooks Dee W. (Libertyville IL) Kolasa Teodozy J. (Lake Villa IL), Aryl and heteroarylmethoxyphenyl inhibitors of leukotriene biosynthesis.
  14. Oku Teruo,JPX ; Kayakiri Hiroshi,JPX ; Satoh Shigeki,JPX ; Abe Yoshito,JPX ; Sawada Yuki,JPX ; Inoue Takayuki,JPX ; Tanaka Hirokazu,JPX, Benzimidazole compounds as bradykinin antagonists.
  15. Lauener, Ronald W.; Burgoyne, David L.; Rebstein, Patrick J.; Mackenzie, Lloyd F.; Zhou, Yuanlin; Shen, Yaping, Benzylated PDE4 inhibitors.
  16. Lauener,Ronald W.; Burgoyne,David L.; Rebstein,Patrick J.; Mackenzie,Lloyd F.; Zhou,Yuanlin; Shen,Yaping, Benzylated PDE4 inhibitors.
  17. Lauener,Ronald W; Burgoyne,David L; Rebstein,Patrick J; Mackenzie,Lloyd F; Zhou,Yuanlin; Shen,Yaping, Benzylated PDE4 inhibitors.
  18. Kolasa Teodozyj (Lake Villa IL) Gunn David E. (Waukegan IL) Brooks Clint D. W. (Libertyville IL), Bis-(Heteroarylmethoxyphenyl)cycloalkyl carboxylates as inhibitors of leukotriene biosynthesis.
  19. Oku Teruo (Tsukuba JPX) Kayakiri Hiroshi (Tsukuba JPX) Satoh Shigeki (Tsukuba JPX) Abe Yoshito (Inashiki-gun JPX) Sawada Yuki (Tsukuba JPX) Inoue Takayuki (Tsukuba JPX) Tanaka Hirokazu (Takarazuka JP, Bradykinin antagonist quinolines.
  20. Freidinger Roger M. (Lansdale PA) Pawluczyk Joseph M. (Warminster PA) Pettibone Douglas J. (Shalfont PA) Williams Peter D. (Harleysville PA), Carbostyril oxytocin receptor antagonists.
  21. Nickel Ardie R. (Fishkill NY) Rosenberg Franklin J. (Bethlehem NY) Ackerman James H. (Rensselaer NY), Composition and method for treatment of hyperuricemia.
  22. Seguin Marie-Christine,FRX ; Babizhayev Marc,SUX, Coupling product obtained from histamine and an amino acid.
  23. de Miranda Antonio (Sao Paulo CA BRX) Vale ; Jr. Wylie W. (La Jolla CA) Rivier Jean E. F. (La Jolla CA) Rivier Catherine L. (La Jolly CA), Cyclic CRF analogs.
  24. Thomas Craig E. ; Fevig Thomas L. ; Bowen Stephen M. ; Farr Robert A. ; Carr Albert A. ; Janowick David A., Cyclic nitrones.
  25. Davalian Dariush ; Beresini Maureen H. ; Alexander Svetlana ; Hu Mae Wan-Leng ; Ullman Edwin F., Cyclosporin immunoassay.
  26. Evangelista Ramon A. (Scarborough CAX) Templeton Eva F. G. (Willowdale CAX) Pollak Alfred (Toronto CAX), Enzyme-amplified lanthanide chelate luminescence.
  27. Sakai Yasuyuki (Tokyo JPX) Suzuki Noriyuki (Oita JPX) Kudo Tetsuo (Oita JPX) Marumo Kuniomi (Oita JPX) Aizawa Toshiyuki (Oita JPX) Imamura Kunio (Tokyo JPX) Sugita Shuichi (Tokyo JPX) Kanbayashi Kazu, External application base or auxiliary agent and external application composition for human being or animal containing t.
  28. Sakai Yasuyuki (Tokyo JPX) Suzuki Noriyuki (Oita JPX) Kudo Tetsuo (Oita JPX) Marumo Kuniomi (Oita JPX) Aizawa Toshiyuki (Oita JPX) Imamura Kunio (Tokyo JPX) Sugita Shuichi (Tokyo JPX) Kanbayashi Kazu, External application base or auxiliary agent and external application composition for human being or animal containing t.
  29. Bai, Hao; Bailey, Simon; Bhumralkar, Dilip Ramakant; Bi, Feng C.; Guo, Fengli; He, Mingying; Humphries, Paul Stuart; Ling, Anthony Lai; Lou, Jihong; Nukui, Seiji; Zhou, Ru, Fused phenyl amido heterocyclic compounds.
  30. Oku Teruo,JPX ; Kayakiri Hiroshi,JPX ; Satoh Shigeki,JPX ; Abe Yoshito,JPX ; Sawada Yuki,JPX ; Inoue Takayuki,JPX ; Tanaka Hirokazu,JPX, Heterocyclic compounds.
  31. Oku Teruo,JPX ; Kayakiri Hiroshi,JPX ; Abe Yoshito,JPX ; Sawada Yuki,JPX ; Mizutani Tsuyoshi,JPX, Heterocyclic compounds as bradykinin antagonists.
  32. Oku Teruo,JPX ; Kayakiri Hiroshi,JPX ; Abe Yoshito,JPX ; Sawada Yuki,JPX ; Mizutani Tsuyoshi,JPX, Heterocyclic compounds as bradykinin antagonists.
  33. Braunlich Gabriele,DEX ; Es-Sayed Mazen,DEX ; Fischer Rudiger,DEX ; Fugmann Burkhardt,DEX ; Henning Rolf,DEX ; Sperzel Michael,DEX ; Nielsch Ulrich,DEX ; Sturton Graham,GBX, Heterocyclylcarbonyl substituted benzofuranyl-ureas.
  34. Oku Teruo (Tsukuba JPX) Kayakiri Hiroshi (Tsukuba JPX) Satoh Shigeki (Tsukuba JPX) Abe Yoshito (Inashiki JPX) Sawada Yuki (Tsukuba JPX) Tanaka Hirokazu (Takarazuka JPX), Imidazo [1,2-a]pyridines and their pharmaceutical use.
  35. Angelastro Michael R. (Cincinnati OH) Bey Philippe (Cincinnati OH) Doherty Niall S. (Stonington CT) Janusz Michael J. (Oregonia OH) Mehdi Shujaath (Cincinnati OH) Peet Norton P. (Cincinnati OH), Inhibitors of Cathepsin G and elastase for preventing connective tissue degradation.
  36. Carson Mathew (Nutley NJ) Han Ru-Jen L. (Princeton Junction NJ) LeMahieu Ronald A. (N. Caldwell NJ) Madison Vincent S. (Mountain Lakes NJ), Intermediates for the production of N-substituted anilines, inhibitors of phospholipases A2.
  37. Lee Kuo-Hsiung (Chapel Hill NC) Bastow Kenneth F. (Chapel Hill NC), Mammalian DNA topoisomerase II inhibitor and method.
  38. Lee Kuo-Hsiung (Chapel Hill NC) Bastow Kenneth F. (Chapel Hill NC), Mammalian DNA topoisomerase II inhibitor and method.
  39. Xu Jinzhu (Ivry sur Seine FRX) Yadan Jean-Claude Y. (Paris FRX) Moutet Marc E. (Bagneux FRX) Chaudiere Jean R. (Saint Maur des Fosses FRX), Method for assaying the sod activity by using a self-oxidizable compound necessary for its implementation, self-oxidizab.
  40. Ternansky Robert J. ; Valentino Karen L. ; Karanewsky Donald S., Method of inhibiting NADPH oxidase.
  41. Ternansky Robert J. ; Valentino Karen L. ; Karanewsky Donald S., Method of inhibiting NADPH oxidase.
  42. Oku Teruo,JPX ; Kayakiri Hiroshi,JPX ; Satoh Shigeki,JPX ; Abe Yoshito,JPX ; Sawada Yuki,JPX ; Tanaka Hirokazu,JPX, Method of preparing certain 3-halo-imidazopyridines.
  43. Carson Mathew (Nutley NJ) Han Ru-Jen L. (Princeton Junction NJ) LeMahieu Ronald A. (N. Caldwell NJ) Madison Vincent S. (Mountain Lakes NJ), N-substituted anilines, inhibitors of phospholipases A2.
  44. Wink ; Jr. David A. ; Mitchell James B. ; Russo Angelo ; Krishna Murali C. ; Hanbauer Ingeborg ; Grisham Matthew B. ; Granger Daniel Neil, Nitric oxide releasing compounds as protective agents in ischemia reperfusion injury.
  45. Sakai Yasuyuki (Tokyo JPX) Suzuki Noriyuki (Oita JPX) Kudo Tetsuo (Oita JPX) Marumo Kuniomi (Oita JPX) Aizawa Toshiyuki (Oita JPX) Imamura Kunio (Tokyo JPX) Sugita Shuichi (Tokyo JPX) Kanbayashi Kazu, Ointment comprising a homogenous mixture of a polymer or copolymer of N-vinylacetamide, water and/or alcohols, and a pha.
  46. Braunlich Gabriele (Wuppertal DEX) Fischer Rudiger (Koln DEX) Es-Sayed Mazen (Wuppertal DEX) Hanko Rudolf (Dusseldorf DEX) Tudhope Stephen (Windsor GB3) Sturton Graham (Bray Maidenhead GB3) Abram Tre, Oxalylamino-benzofuran- and benzothienyl-derivatives.
  47. Crapo James D. ; Fridovich Irwin ; Oury Tim ; Day Brian J. ; Folz Rodney J. ; Freeman Bruce A. ; Trova Michael P. ; Batinic-Haberle Ines, Oxidant scavengers.
  48. Itoh Yoshikuni,JPX ; Iwamoto Toshiro,JPX ; Yatabe Takumi,JPX ; Hamashima Hitoshi,JPX ; Inoue Takayuki,JPX ; Hashimoto Seiji,JPX ; Oku Teruo,JPX, Peptide compounds for treatment of no-mediated diseases.
  49. Noda Toshiharu (Houston TX) Morita Kaoru (Shizuoka JPX) Kobari Sadami (Mishima JPX) Nakagawa Nobuaki (Shizuoka JPX) Watanabe Susumu (Shizuoka JPX) Katsuragi Shigeo (Shizuoka JPX) Ohyama Kunio (Shizuo, Peptides for assaying human parathyroid hormone.
  50. van\t Riet Bartholomeus (3419 Noble Ave. Richmond VA 23222) Elford Howard L. (3313 Gloucester Rd. Richmond VA 23227) Wampler Galen L. (6938 Chamberlayne Rd. Mechanicsville VA 23111), Polyhydroxybenzoic acid derivatives.
  51. Smith Daniel J. (Stow OH) Chakravarthy Debashish (Garrettsville OH) Keefer Larry K. (Bethesda MD), Polysaccharide-bound nitric oxide-nucleophile adducts.
  52. Mills Randell Lee, Pro drugs for selective drug delivery.
  53. Marciniak Gilbert (Dachstein FRX) Schnettler Richard A. (Cincinnati OH) Ayers Timothy A. (Loveland OH) Krysan Damian J. (Cincinnati OH), Process for preparing 2,3-dihydro-benzofuranol derivatives.
  54. Mills Randell L. (R.D. #2 Cochranville PA 19330), Prodrugs for selective drug delivery.
  55. Hawkins Mary E. (Potomac MD) Pfleiderer Wolfgang (Konstanz MD DEX) Davis Michael D. (Rockville MD) Balis Frank (Bethesda MD), Pteridine nucleotide analogs as fluorescent DNA probes.
  56. Hawkins Mary E. (Potomac MD) Pfleiderer Wolfgang (Constance DEX) Davis Michael D. (Rockville MD) Balis Frank (Bethesda MD), Pteridine nucletide analogs as fluorescent DNA probes.
  57. Oku Teruo,JPX ; Kayakiri Hiroshi,JPX ; Satoh Shigeki,JPX ; Abe Yoshito,JPX ; Sawada Yuki,JPX ; Inoue Takayuki,JPX ; Tanaka Hirokazu,JPX, Pyridopyrimidones, quinolines and fused N-heterocycles as bradykinin antagonists.
  58. Oku Teruo,JPX ; Kayakiri Hiroshi,JPX ; Satoh Shigeki,JPX ; Abe Yoshito,JPX ; Sawada Yuki,JPX ; Inoue Takayuki,JPX ; Tanaka Hirokazu,JPX, Quinoline derivatives, processes for their preparation and their use as medicaments.
  59. Saavedra Joseph E. ; Keefer Larry K. ; Billiar Timothy R., Selective prevention of organ injury in sepsis and shock using selection release of nitric oxide in vulnerable organs.
  60. Chen, Changyi; Lu, Jian-Ming; Yao, Qizhi, Small molecule xanthine oxidase inhibitors and methods of use.
  61. Chen, Changyi; Lu, Jian-Ming; Yao, Qizhi, Small molecule xanthine oxidase inhibitors and methods of use.
  62. Chen, Changyi; Lu, Jian-Ming; Yao, Qizhi, Small molecule xanthine oxidase inhibitors and methods of use.
  63. Chen, Changyi; Lu, Jian-Ming; Yao, Qizhi, Small molecule xanthine oxidase inhibitors and methods of use.
  64. Shen, Yaping; Burgoyne, David L.; Lauener, Ronald W.; Zhou, Yuanlin; Rebstein, Patrick J.; Abraham, Samuel D. M., Substituted γ-phenyl-Δ-lactams and uses related thereto.
  65. Yaping Shen CA; David L. Burgoyne CA; Ronald W. Lauener CA; Yuanlin Zhou CA; Patrick J. Rebstein CA; Samuel D. M. Abraham CA, Substituted .gamma.-phenyl-.DELTA.-lactones and analogs thereof and uses related thereto.
  66. Shen ; Tsung-Ying ; Jones ; Howard, Sulphonic acid containing indenyl derivatives.
  67. Turk Richard S. (Elkhart IN) Zipp Adam P. (Goshen IN), Test means and assay for determining the urea content of fluids.
  68. Takasugi Hisashi (Osaka JPX) Nishino Shigetaka (Osaka JPX) Tanaka Akito (Takarazuka JPX), Thiazole compounds and pharmaceutical composition comprising the same.
  69. Doherty James B. (New Milford NJ) Zimmerman Morris (Watchung NJ) Ashe Bonnie M. (Westfield NJ), Thienamycin derivatives as anti-inflammatory agents.
  70. Leftheris Katerina, Thioproline-containing inhibitors of farnesyl protein transferase.
  71. Boyle Francis Thomas,GB3 ; Crook James William,GB3 ; Matusiak Zbigniew Stanley,GB3, Tricyclic compounds with pharmaceutical activity.
  72. Baldwin ; John J. ; Novello ; Frederick C., Trifluoromethylimidazoles and a method for their preparation.
  73. Brooks Dee W. (Libertyville IL) Kerkman Daniel J. (Lake Villa IL) Martin Jonathan G. (Waukegan IL) Stewart Andrew O. (Wildwood IL) Summers James B. (Libertyville IL), Urea based lipoxygenase inhibiting compounds.
  74. Keefer Larry K. ; Saavedra Joseph E. ; Doherty Paul C. ; Hanamoto Mark S. ; Place Virgil A., Use of nitric oxide-releasing agents to treat impotency.
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