Crosslinked human or animal tissue products and their methods of manufacture and use
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
C09H-001/00
A61L-027/24
A61K-038/39
A61K-038/17
A61K-038/16
A61L-027/36
A61L-027/54
A61L-027/58
C07K-014/78
출원번호
US-0527571
(2014-10-29)
등록번호
US-9592320
(2017-03-14)
발명자
/ 주소
Mezger, W. Jerry
Myers, Keith E.
출원인 / 주소
HARBOR MEDTECH, INC.
대리인 / 주소
Knobbie, Martens, Olson & Bear, LLP
인용정보
피인용 횟수 :
0인용 특허 :
68
초록▼
Degradable bioprostheses made of collagen-based material having amine-based and ester-based crosslinks are provided, as are methods for their formation and use. Some embodiments of the present invention are directed towards a method of controlling the ratio of amine-based crosslinks to ester-based c
Degradable bioprostheses made of collagen-based material having amine-based and ester-based crosslinks are provided, as are methods for their formation and use. Some embodiments of the present invention are directed towards a method of controlling the ratio of amine-based crosslinks to ester-based crosslinks within a collagen-based material to provide a tailorably crosslinked collagen-based material. Some embodiments provide a method of making a degradable bioprosthesis involving controlling crosslinking to afford a degradable bioprosthesis that is partially crosslinked. By controlling the ratio of amine-based to ester-based crosslinks, by controlling the level of crosslinking, or by controlling both of these features, degradable bioprostheses with tailored degradation rates can be synthesized. Some embodiments of degradable bioprostheses have degradation rates that are tailored to allow their use in particular medical applications. Some embodiments are directed towards methods of use degradable bioprostheses in wound healing, tissue repair, and tissue supplementation.
대표청구항▼
1. A method of treating a tissue defect comprising: positioning a degradable bioprosthesis at, over, or into the tissue defect, wherein the degradable bioprosthesis comprises:a crosslinked collagen-based material comprising Crosslink A, Crosslink B, and free amines (—NH2): wherein: indicates collage
1. A method of treating a tissue defect comprising: positioning a degradable bioprosthesis at, over, or into the tissue defect, wherein the degradable bioprosthesis comprises:a crosslinked collagen-based material comprising Crosslink A, Crosslink B, and free amines (—NH2): wherein: indicates collagen strands;R1 is R2 is R3 and R4 are independently selected from the group consisting of —CH2—O—(CH2)n—O—CH2— and —CH2—(O(CH2)n)m—O—CH2—, andn and m are independently an integer from 1-6;wherein the crosslinked collagen based material has a degradation rate between about 0.2% to about 1.0% per hour during the first 24 hours of exposure to a pronase digestion assay. 2. The method of claim 1, wherein the tissue defect is a defect selected from the group consisting of a tendon defect, a ligament defect, vaginal prolapse, a hernia, a tissue defect that causes urinary incontinence, a gum defect, an organ defect, a tissue defect that results from bariatric surgery, and a wound. 3. The method of claim 1, wherein the tissue defect is a tendon defect. 4. The method of claim 1, wherein the tissue defect is a ligament defect. 5. The method of claim 1, wherein the tissue defect is vaginal prolapse. 6. The method of claim 1, wherein the tissue defect is a hernia. 7. The method of claim 1, wherein the tissue defect causes urinary incontinence. 8. The method of claim 1, wherein the tissue defect is a gum defect. 9. The method of claim 1, wherein the tissue defect is an organ defect. 10. The method of claim 1, wherein the tissue defect is as a result of bariatric surgery. 11. The method of claim 1, wherein the tissue defect is a wound. 12. The method of claim 1, wherein the degradable bioprosthesis is derived from animal pericardium. 13. The method of claim 1, wherein the degradable bioprosthesis is attached to the tissue defect. 14. The method of claim 1, wherein the degradable bioprosthesis comprises a flexible sheet. 15. The method of claim 14, wherein the flexible sheet is between about 1 cm2 and about 500 cm2. 16. The method of claim 14, wherein the flexible sheet is treated with antimicrobial agent.
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