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Automated analyzer for performing a nucleic acid-based assay

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C12M-001/34
  • C12M-001/40
  • C12Q-001/68
  • B01F-009/00
  • B01L-007/00
  • B03C-001/28
  • B03C-001/30
  • G01N-035/02
  • B01L-009/06
  • G01N-035/00
  • G01N-035/10
  • G01N-035/04
출원번호 US-0873818 (2007-10-17)
등록번호 US-9598723 (2017-03-21)
발명자 / 주소
  • Ammann, Kelly G.
  • Burns, Ralph E.
  • Hansberry, Ernest V.
  • Horner, Glenn A.
  • Jakub, Cheryl A.
  • Kling, John E.
  • Nieglos, Donald J.
  • Schneider, Robert E.
  • Smith, Robert J.
출원인 / 주소
  • GEN-PROBE INCORPORATED
대리인 / 주소
    Cappellari, Charles B.
인용정보 피인용 횟수 : 0  인용 특허 : 348

초록

An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations, or modules, in which discrete aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automatically preparing a specimen sample

대표청구항

1. An automated analyzer for use in performing a nucleic acid-based assay, the analyzer comprising: a separation station comprising a magnetic element for subjecting a sample to a magnetic field, the magnetic field being sufficient to isolate a target nucleic acid immobilized on a solid support comp

이 특허에 인용된 특허 (348)

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  141. Carbonari Larry Alfred ; Turpen Jon D., Chemistry analyzer.
  142. Korenberg Julie R. ; Yamakawa Kazuhiro, Chromosome 21 gene marker, compositions and methods using same.
  143. Malin Cosmas,LIX ; Sawatzki Harry,LIX ; Gentsch Jurg,CHX ; Helwig Gunter,DEX, Climatic cabinet, turntable and use of the turntable.
  144. Neri Bruce P. ; Curtis John S.,GB2 ; Collins Mark L. ; Ryan Danahey, Closed vessel for isolating target molecules and for performing amplification.
  145. Scordato Richard E. (Scarsdale NY), Coagulation instrument for performing clotting tests.
  146. Wittwer,Carl T.; Ririe,Kirk M., Container for carrying out and monitoring biological processes.
  147. Schnipelsky Paul N. (Rochester NY) Seaberg Leonard J. (Penfield NY) Hinckley Charles C. (Pittsford NY) Wellman Jeffrey A. (Rochester NY) Donish William H. (Rochester NY) Findlay John B. (Rochester NY, Containment cuvette for PCR and method of use.
  148. Hugh, Mark A., Controlled atmosphere incubator.
  149. Kurosaki Tsuyoshi (Hyogo JPX) Nakagawa Masayuki (Hyogo JPX), Cuvette and cuvette-transporting apparatus.
  150. Hunnell Jack E. (Durham NC), DNA hybridization incubator.
  151. Fraiser Melinda S. (Durham NC) Walker George T. (Chapel Hill NC) Schram James L. (Knightdale NC), Decontamination of nucleic acid amplification reactions using uracil-N-glycosylase (UDG).
  152. Tyagi Sanjay ; Kramer Fred R. ; Lizardi Paul M.,MXX, Detectably labeled dual conformation oligonucleotide probes, assays and kits.
  153. Ranki Tuula M. (Espoo FIX) Soderlund Hans E. (Espoo FIX), Detection of microbial nucleic acids by a one-step sandwich hybridization test.
  154. Nadeau James G. ; Pitner J. Bruce ; Schram James L. ; Linn C. Preston ; Vonk Glenn P. ; Walker G. Terrance, Detection of nucleic acids by fluorescence quenching.
  155. Smith Roger E. (Bountiful UT) Smith Randall W. (Sandy UT), Detector assembly for analyzer instrument.
  156. Cottingham Hugh V., Device and method for DNA amplification and assay.
  157. Kawaguchi Seiji,JPX ; Kono Toshiaki,JPX ; Hayashi Hidechika,JPX, Device and method for automatic sample pretreatment.
  158. Ammann,Kelly G.; Hansberry,Ernest V., Device for agitating the fluid contents of a container.
  159. Burg, J. Lawrence; Catanzariti, Luigi; Vera-Garcia, Marcela; Moe, James G., Device for automated detection of nucleic acids.
  160. Choperena Alfredo (Eden Prairie MN) Krogh Ross (Minneapolis MN) Prasad Venkatesh (Eden Prairie MN) Giter Gershon (St. Paul MN), Device for automatic chemical analysis.
  161. Choperena Alfredo (Eden Prairie MN) Krogh Ross (Minneapolis MN) Prasad Venkatesh (Eden Prairie MN) Giter Gershon (St. Paul MN), Device for automatic chemical analysis.
  162. Choperena Alfredo ; Krogh Ross ; Prasad Venkatesh ; Giter Gershon, Device for automatic chemical analysis.
  163. Litsche Mario (Nellmersbach DEX), Device for transporting containers filled with a liquid.
  164. Bienhaus Gerhard,DEX ; Lange Hans,DEX, Device for treating nucleic acids from a sample.
  165. Eden Gideon (Ann Arbor MI), Diagnostic microbiological testing apparatus and method.
  166. Schacher Gottlieb (Ebikon CHX), Diagnostic processing station.
  167. Robinson David (Folkestone GB2) Bate Ernest (Great Chart GB2) Kellard Simon (Ashford GB2) Watson Mark (Ashford MA GB2) Mahan Donald E. (Grafton MA) Shimei Thomas M. (Franklin MA) Kearney Kevin R. (Wo, Diagnostics instrument.
  168. Takeuchi Masaki (Otawara JPX), Discrete type automated chemical analytic apparatus.
  169. Sakuma Yoshihiro (Tochigi JPX) Shivutani Hitoshi (Ootawara JPX), Distribution nozzle apparatus for automatic chemical analyzer.
  170. Catanzariti Luigi ; Kluttz Bryan W. ; McKinley Geoff A. ; Garland Arthur L. ; Graziano Louis ; Moe James G. ; Vera-Garcia Marcela ; Bishop James Clement ; Chastain David ; Gennari Fabio,ITX, Dual chamber disposable reaction vessel for amplification reactions, reaction processing station therefor, and methods o.
  171. Diamond Ronald N ; Otter Michael ; Hu Thomas Sheng-Shyong ; Stark William A, Dual injector for chemiluminescence immunoanalyzing system.
  172. Govyadinov,Alexander; Regan,Michael J., Emitter and method of making.
  173. Gillespie David H. (Glenmore PA), Evaluation of nucleic acids in a biological sample hybridization in a solution of chaotrophic salt solubilized cells.
  174. Carey Glen A. (Grafton OH) Lewis Scott C. (Amherst OH) Whitesel Mary B. (Grafton OH), Feed and orientation mechanism in automated analyzer.
  175. Eddelman Roy T. (60916 Terminal Annex Los Angeles CA 90054), Ferromagnetic separation process and material.
  176. Kureshy Fareed (Westwood MA) Long Ernest W. (Concord MA) Singh Shailendra (Sharon MA), Fluid dispensing system with optical locator.
  177. Glen Carey ; Scott C. Lewis ; Mary Beth Whitesel ; Frank C. Klingshirn, Fluid handling apparatus for an automated analyzer.
  178. Heiss Louis R. (Annapolis MD), Fluorometric analyzer including shutter means for simultaneously shielding sample and photodetector during sample change.
  179. Przybylowicz Catherine S. (Rochester NY) Jacobs Merrit N. (Fairport NY) Douglas Joseph S. (Rochester NY), Grooved cover for test elements.
  180. Tyranski James T. (Oakwood Hills IL) Dunn Chadwick M. (Vernon Hills IL) Grandone Cass J. (Lake Forest IL) Ludington Kris T. (Brewster NY), Heat and air flow control for assay carrier.
  181. Liu Yen Ping ; Patel Rajesh D. ; Kurn Nurith ; Lin Claire ; Rose Samuel J. ; Ullman Edwin F., Homogeneous amplification and detection of nucleic acids.
  182. Sutherland John W. H. (Rochester NY) Patterson David R. (Rochester NY), Homogeneous method for assay of double-stranded nucleic acids using fluorescent dyes and kit useful therein.
  183. Higuchi Russell G., Homogeneous methods for nucleic acid amplification and detection.
  184. Arnold ; Jr. Lyle J. (San Diego CA) Nelson Norman C. (San Diego CA), Homogeneous protection assay.
  185. Arnold ; Jr. Lyle J. (San Diego CA) Nelson Norman C. (San Diego CA), Homogenous protection assay.
  186. Okada Satoru (Hyogo JPX) Mizuno Yoshiteru (Hyogo JPX) Izumi Takayoshi (Hyogo JPX) Otani Toshihiro (Hyogo JPX), Immunoagglutination measurement apparatus.
  187. Bagasra Omar (Laurel Springs NJ) Pomerantz Roger J. (Chalfont PA), In situ polymerase chain reaction.
  188. Carey Glen A. (Grafton OH) Malek Michael L. (North Olmsted OH), Incubation chamber.
  189. Carey Glen A. ; Malek Michael L., Incubation chamber.
  190. Maes Gregory R. ; Connor Dennis M. ; Freiner Brent D. ; Karl Clifford W. ; Robinson Ron ; Shelton Raymond M. ; Tegeler Garry R. ; Justin Michael James, Incubation station for test sample cards.
  191. Muka ; Edward ; Glover ; Clyde Pershing, Incubator and radiometric scanner.
  192. Ammann,Kelly G.; Schneider,Robert E.; Smith,Robert J., Incubator for use in an automated diagnostic analyzer.
  193. DiFulvio Anthony P. (Rochester NY) Smith Michael R. (Rochester NY), Incubator including cover means for an analysis slide.
  194. Kureshy Fareed (Westwood) DeAngelis Charles A. (Westwood) MacIndoe ; Jr. Robert C. (Linwood MA), Incubator port closure for automated assay system.
  195. Muszak Martin F. (Rochester) Hartman Gary S. (Rochester) Leighton Roger G. (Rochester NY), Incubator with positioning device for slide elements.
  196. Wilson Stuart (Enfield GB2) Goodfield Clive (Mid Glamorgan GB7) Stafford David A. (Cardiff GB7) Johnson Ian R. (Mid Glamorgan GB7), Injection systems for sample testing for luminometers.
  197. Fukuoka Masayoshi (Tokyo JPX) Matsuyuki Akira (Tokyo JPX), Instrument for quantitative analysis.
  198. Petschek Harry E. (Lexington MA) Kaufmann Henry (Danville NH) Quinlan Robert A. (Beverly MA) DeBonville David A. (Beverly MA) Sklar Martin J. (Needham MA) Danehy Ronald D. (Tewksbury MA) Foley Michae, Integral biomolecule preparation device.
  199. Anderson Rolfe C. ; Lipshutz Robert J. ; Rava Richard P. ; Fodor Stephen P. A., Integrated nucleic acid diagnostic device.
  200. Atwood John G. (Redding CT) Marshall ; Jr. Hamilton W. (Ridgefield CT) Heinz Peter H. (Trumbull CT), Kinetic analyzer.
  201. Kahl Murray (12083 Regal Ct. W. West Palm Beach FL 33414), Laboratory mixer.
  202. Fujii Yoshio (Katsuta JPX) Yoshida Kasumi (Mito JPX) Miura Junkichi (Katsuta JPX) Satake Hiroshi (Katsuta JPX) Ito Masahito (Katsuta JPX), Liquid chromatographic analyzer, sample feeder and prelabeling reaction treating method.
  203. Andersen Marlo R. (Veradale WA) Tiffany Thomas O. (Spokane WA) Gangitano Mario J. (Anaheim CA), Liquid handling.
  204. Andersen Marlo R. (Veradale WA) Tiffany Thomas O. (Spokane WA) Gangitano Mario J. (Anaheim CA), Liquid handling.
  205. Tajima Hideji,JPX, Liquid processing method making use of pipette device and apparatus for same.
  206. Sano Kazuhiro (Ibaraki JPX) Kai Susumu (Katsuta JPX) Yonekawa Shigeru (Katsuta JPX), Liquid sample automatic analyzer.
  207. Aihara Takayuki (Hachioji JPX), Liquid transfer apparatus for automatic analyzers.
  208. Liston Max D. (Irvine CA) Hsei Paul K. (Huntington Beach CA), Loading and transfer assembly for chemical analyzer.
  209. Wihlborg Nils (Helsingborg SEX), Luminescence measuring system and luminometer device.
  210. Andreotti Peter E. (Lauderhill FL) Morse Irwin S. (Miami FL) Thornthwaite Jerry T. (Miami FL) Heimer Malcolm L. (Miami FL) Salinger Jorge D. (Miami FL) Sobodowski Joseph J. (Miami FL), Luminometer.
  211. Barr Howard S. (Escondido CA) Sancoff Gregory E. (Leucadia CA) McWilliams Mark (San Diego CA), Luminometer.
  212. Lewis Scott C. (864 Crosse Ave. Amherst OH 44001) Pabst Stefan R. (21484 Hawley Rd. Wellington OH 44090), Luminometer.
  213. Malek Michael L. (North Olmsted OH) Carey Glen A. (Grafton OH) Coghlan Gregory A. (Elyria OH), Luminometer.
  214. Malek Michael L. ; Carey Glen A. ; Coghlan Gregory A., Luminometer.
  215. Johnson Ian R. (“Winsford”Heol St. Bridget St. Brides Major GB7 CF32 OSL) Stafford David A. (26 Forsythia Drive ; Greenways Cyncoed ; Cardiff GB7) Hall Robert A. (39 Hambledon Road ; Clanfield Port, Luminometer construction.
  216. Carey Glen A. (Grafton OH) Lewis Scott C. (Amherst OH) Whitesel Mary Beth (Grafton OH) Woyansky George J. (Westlake OH) Pabst Stefan R. (Wellington OH) Klingshirn Frank C. (Medina OH), Luminometer for an automated analyzer.
  217. Smethers Rick T. (Fremont CA) Warner Brian D. (Martinez CA) Burolla Victor P. (Livermore CA), Luminometer with reduced sample crosstalk.
  218. Smethers Rick T. ; Warner Brian D. ; Burolla Victor P., Luminometer with reduced sample crosstalk.
  219. Michel Coeurveille FR, Luminometer, particularly for medical assays.
  220. Stafford David A. (Cardiff GBX) Johnson Ian R. (Mid Glamorgan GBX) Goodfield Clive (Pontypridd GBX), Luminometers with sample container displacement controlled by ramped abutment.
  221. Reeve Michael Alan (Oxon GBX) Robinson Philip Steven (Bucks GBX), Magnetic bead precipitation method.
  222. Powell Ralph (Spring TX) Phillips Alisa (Tyngsboro MA) Jackson Barbara (Watertown MA), Magnetic capture rack with slidable magnetic member.
  223. Lapeus David J. ; Ballash Michael, Magnetic conveyor system.
  224. Matte Claude (Paris FRX) Muller Anne (Gif/Yvette FRX), Magnetic device for immunological analysis of a solid phase.
  225. Tajima Hideji (Tokyo JPX), Magnetic material attracting/releasing control method making use of a pipette device and various types of analyzer using.
  226. Howe Roland Paul,GBX ; Reeve Michael Alan,GBX ; Bischof Daniel,CHX, Magnetic separation method.
  227. Wang Robert (San Diego CA), Magnetic separation rack for diagnostic assays.
  228. Berthold Fritz (Pforzheim DEX) Lohr Willy (Wildbad DEX), Measuring instrument for bioluminescence and chemilumnescence or turbidimetry.
  229. Leistner Hermann,DEX ; Schiessl Hans,DEX, Measuring system and method for performing luminometric series analyses as well as multiple cuvette for receiving liquid.
  230. Leistner Hermann,DEX ; Schiessl Hans,DEX, Measuring system and method for performing luminometric series analyses as well as multiple cuvette for receiving liquid samples therefor.
  231. Wilding Peter (Paoli PA) Kricka Larry J. (Berwyn PA), Mesoscale polynucleotide amplification devices.
  232. Mitsumaki Hiroshi (Mito JPX) Takahashi Katsuaki (Katsuta JPX), Method and apparatus for automatically analyzing a plurality of test items.
  233. Laska Paul F. (510 Wyndham Rd. Wilmington DE 19809) Imai Kyoko (Ichige 622-23 Katsuta ; Ibaraki JPX) Hashimoto Hiroshi (Tokai 1616 Nakagun ; Ibaraki JPX) Betsui Hajime (Tahiko 1409-2 Katsuta ; Ibarak, Method and apparatus for effecting a plurality of assays on a plurality of samples in an automatic analytical device.
  234. Astle Thomas W. (607 Harborview Rd. Orange CT 06477), Method and apparatus for effecting solid phase extraction.
  235. Farber Fredric (Brookline MA), Method and apparatus for magnetically separating biological particles from a mixture.
  236. Ammann, Kelly G.; Burns, Ralph E.; Hansberry, Ernest V.; Horner, Glenn A.; Jakub, Cheryl A.; Kling, John E.; Nieglos, Donald J.; Schneider, Robert E.; Smith, Robert J., Method and apparatus for performing a magnetic separation purification procedure on a sample solution.
  237. Kegelman Joseph Edward ; Mizzer John Paul ; Nuzzaci Edward Anthony ; Chow Allan Tit-Shing, Method and apparatus for pre-treating samples in an automatic chemical analyzer.
  238. Bendele Teresa M. ; Harrison Linda A. ; Howard David J. ; Knotts Lori K. ; Malek Michael L. ; Veverka Todd A., Method and apparatus for wash, resuspension, recollection and localization of magnetizable particles in assays using magnetic separation technology.
  239. Breeser David ; Wirbisky Alan ; Krogh Ross, Method and device for automatic chemical analysis.
  240. Choperena Alfredo (Eden Prairie MN) Krogh Ross (Minneapolis MN) Prasad Venkatesh (Eden Prairie MN) Giter Gershon (St. Paul MN), Method and device for automatic chemical analysis.
  241. Astle Thomas W., Method and device for simultaneously transferring plural samples.
  242. Dattagupta Nanibhushan (San Diego CA) Ryder Thomas B. (Escondido CA) Kacian Daniel L. (San Diego CA) Kamisango Keiichi (San Diego CA), Method and kit for destroying ability of nucleic acid to be amplified.
  243. Ammann, Kelly G.; Hansberry, Ernest V., Method for agitating the fluid contents of a container.
  244. Furuta Yoshiteru (Katsuta JPX) Nomura Yasushi (Mito JPX), Method for analyzing liquid sample.
  245. Mitsumaki, Hiroshi; Takahata, Fujiya, Method for analyzing samples and automatic processor therefor.
  246. Markin Rodney S., Method for automatic testing of laboratory specimens.
  247. Lee Ching-Cherng (Newark DE) Davis James E. (Wilmington DE), Method for automatically processing magnetic solid phase reagents.
  248. Ammann, Kelly G.; Burns, Ralph E.; Hansberry, Ernest V.; Horner, Glenn A.; Jakub, Cheryl A.; Kling, John E.; Nieglos, Donald J.; Schneider, Robert E.; Smith, Robert J., Method for detecting the presence of a nucleic acid in a sample.
  249. Ammann, Kelly G.; Burns, Ralph E.; Hansberry, Ernest V.; Horner, Glenn A.; Jakub, Cheryl A.; Kling, John E.; Nieglos, Donald J.; Schneider, Robert E.; Smith, Robert J., Method for detecting the presence of a nucleic acid in a sample.
  250. Bouma Stanley R. (Grayslake IL) Khalil Omar S. (Libertyville IL) Pabich Edward K. (Chicago IL), Method for detection of nucleic acid using total internal reflectance.
  251. Ringrose Anthony (124 ; Chemin de la Montagne 1224 Chene-Bougeries CHX) Farkas Rudolf (38 ; Av. William Favre 1207 Geneva CHX) Nicole Andre (17 ; chemin de la Gouille-Noire 1244 Choulex CHX) Prost Je, Method for measuring antigens or antibodies in biological fluids.
  252. Siddiqi Iqbal W., Method for mixing and separation employing magnetic particles.
  253. Adams Christopher P. (Winter Hill MA) Kron Stephen Joseph (Boston MA), Method for performing amplification of nucleic acid with two primers bound to a single solid support.
  254. Wuerschum Hans-Peter (Ostfildern DEX), Method for scanning and centering containers filled with a liquid.
  255. Ammann, Kelly G.; Burns, Ralph E.; Hansberry, Ernest V.; Horner, Glenn A.; Jakub, Cheryl A.; Kling, John E.; Nieglos, Donald J.; Schneider, Robert E.; Smith, Robert J., Method for simultaneously performing multiple amplification reactions.
  256. Tajima Hideji,JPX, Method for treating biopolymers, microorganisms or materials by using more than one type of magnetic particles.
  257. Takekawa Hiroshi (Kunitachi JPX), Method of automatically analyzing chemical substances and an automatic chemical analyzer.
  258. Kodama Ryuichiro,JPX ; Mitsumaki Hiroshi,JPX ; Mimura Tomonori,JPX ; Noda Takayuki,JPX, Method of conveying sample rack and automated analyzer in which sample rack is conveyed.
  259. Oka Takanori (Hiroshima JPX) Matsunaga Hironari (Hiroshima JPX) Yamane Akio (Hiroshima JPX), Method of nucleic acid-differentiation and assay kit for nucleic acid differentiation.
  260. Arnquist David C. ; Barnes ; III Grady ; Dunn Chadwick M. ; East ; Jr. Richard C. ; Fritchie Patrick P. ; Gardner Gregory E. ; Grandone Cass J. ; Gray Robert C. ; Holen James T. ; McCoy Jimmy D. ; Mi, Method of performing a process for determining an item of interest in a sample.
  261. Fujita Hiroko,JPX ; Hattori Mitsuo,JPX ; Murakami Emi,JPX ; Shibata Yasuhisa,JPX, Method of washing container used for reaction of body liquid sample and reagent.
  262. Stabinsky Yitzhak (Boulder CO), Methods and kits for performing nucleic acid hybridization assays.
  263. Gleason Paul J ; Miller Robert D ; Bare Rex O ; Mahant Vijay K. ; Feistel Christopher C ; Walker Glenn D., Methods for conducting tests.
  264. Raymoure William J. (Lake Bluff IL) Clark Frederic L. (Plano TX) Clift Gibert (Mesquite TX) Hendrick Kendall B. (Southlake TX) Kanewske ; III William J. (Dallas TX) Lagocki Peter A. (Park Ridge IL) M, Methods for providing homogeneous reagents.
  265. Coull James M. ; Hyldig-Nielsen Jens J. ; Godtfredsen Sven E.,DKX ; Fiandaca Mark J. ; Stefano Kyriaki, Methods for suppressing the binding of detectable probes to non-target sequences in hybridization assays.
  266. Perlman Daniel (Arlington MA), Microtube vortexer adapter and method of its use.
  267. Herold Wolf-Dietrich (Seefeld DEX) Koran Peter (Weilheim DEX), Mixing apparatus for pastes.
  268. Lillig John E. (Diamond Bar CA) Whelan Michael J. (Anaheim Hills CA) Cheon Thomas V. (Costa Mesa CA) Sisson Patricia A. (Santa Ana CA) Flores Orlando (Anaheim CA), Modular analyzer system.
  269. Rodriguez Rodolfo R. (Columbia MD) Achter Eugene K. (Gaithersburg MD) Deaton Carlton D. (Garden Grove CA) Goldsmith Herbert (Rockville MD) Dorman Horton E. (Silver Spring MD), Modular chemical analysis system.
  270. Burkovich Robert A. (Newark DE) Lipscomb James H. (Kennett Square PA) Nurse Colin A. (Newark DE) Wong Kin W. (Claymont DE) Zuk Paul J. (Lincoln University PA) Bernstine Robert E. (Chesapeake City MD), Multi-linear automatic apparatus for processing immunoassays.
  271. Modlin, Douglas N.; Owicki, John C.; Petersen, Jon F.; French, Todd E.; Wright, Carl L.; Ruiz, Jeanne A.; Bechtel, Lorne E., Multi-mode light detection system.
  272. Christian Clifford N. (Costa Mesa CA), Multiple assay card and system.
  273. Kevin Maher ; Timothy F. Smith ; Torleif Ove Bjornson, Multiplexed fluorescent detection in microfluidic devices.
  274. Nazarenko Irina A. ; Bhatnagar Satish K. ; Winn-Deen Emily S. ; Hohman Robert J., Nucleic acid amplification oligonucleotides with molecular energy transfer labels and methods based thereon.
  275. Haff Lawrence A. ; Picozza Enrico ; Bloch Will ; Ragusa Robert ; DiCesare Joseph ; Tracy David ; Saviano Paul ; Woudenberg Timothy M., Nucleic acid amplification reaction apparatus.
  276. Haff Lawrence A. ; Picozza Enrico ; Bloch Will ; Ragusa Robert ; DiCesare Joseph ; Tracy David ; Saviano Paul ; Woudenberg Timothy M. ; Noreiks Richard W., Nucleic acid amplification reaction apparatus and method.
  277. Burg J. Lawrence ; Catanzariti Luigi ; Kluttz Bryan W. ; McKinley Geoff A. ; Moe James G. ; Vera-Garcia Marcela, Nucleic acid assays.
  278. Sammes Peter George,GBX ; Garman Andrew John,GBX, Nucleic acid detection with energy transfer.
  279. Walder Joseph A. (Iowa City IA) Walder Roxanne Y. (Iowa City IA), Nucleic acid hybridization and amplification method for detection of specific sequences in which a complementary labeled.
  280. Chen Paul H.-D. (Boston MA) Findlay John B. (Rochester NY) Atwood Susan M. (Newark NY) Bergmeyer Lynn (Rochester NY), Nucleic acid material amplification and detection without washing.
  281. Kacian Daniel L. (San Diego CA) McAllister Diane L. (San Diego CA) McDonough Sherrol H. (San Diego CA) Dattagupta Nanibhushan (San Diego CA), Nucleic acid sequence amplification method, composition and kit.
  282. Kacian Daniel L. (San Diego CA) Fultz Timothy J. (Vista CA), Nucleic acid sequence amplification methods.
  283. Kacian Daniel L. (San Diego CA) Fultz Timothy J. (Vista CA), Nucleic acid sequence amplification methods.
  284. Findlay John B. (Rochester NY) Mayer Janice M. (Rochester NY) King Marlene M. (Penfield NY) Oakes Fred T. (Rochester NY) Chang Chu-an (El Cerrito CA) Levenson Corey H. (Oakland CA), Nucleic acid test article and its use to detect a predetermined nucleic acid.
  285. Edelmann Hermann (Tutzing-Unterzeismering DEX) Pasch Manfred (Tutzing DEX) Mann Karlheinz (Weilheim DEX) Sattler Stephan (Socking DEX) Haar Hans-Peter (Weilheim DEX), Photometric analysis apparatus for a liquid.
  286. Pardinas Guillermo P. (Miami FL), Pipette tip with self-aligning and self-sealing features.
  287. Chemelli John B. (Webster NY), Positive flow control in an unvented container.
  288. Sayers Anthony D. (Crawley GB2), Power amplifier and a transmitter including the power amplifier.
  289. Kwoh Deborah Y. (Carlsbad CA) Gingeras Thomas R. (Encinitas CA), Prenatal sex determination of bovine cells using male-specific oligonucleotides.
  290. Lange Hans,DEX, Process and device for isolating nucleic acids.
  291. Matte Claude (Paris FRX) Muller Anne (Gif/Yvette FRX), Process and magnetic device for immunological analysis of a solid phase.
  292. Mullis Kary B. (Kensington CA), Process for amplifying nucleic acid sequences.
  293. Mullis Kary B. (Kensington CA) Erlich Henry A. (Oakland CA) Arnheim Norman (Woodland Hills CA) Horn Glenn T. (Emeryville CA) Saiki Randall K. (Richmond CA) Scharf Stephen J. (Berkeley CA), Process for amplifying, detecting, and/or-cloning nucleic acid sequences.
  294. Van Gemen Bob (Boxtel NLX) Schukkink Adriana Frederieke (Houten NLX), Process for rendering a nucleic acid amplication reaction product incapable of being a target for further amplification,.
  295. DeVaney ; Jr. Mark J. (Rochester NY) Lercher John S. (Rochester NY) Wellman Jeffrey A. (Rochester NY), Processing apparatus for a chemical reaction pack.
  296. Arnold ; Jr. Lyle J. (San Diego CA) Waldrop ; III Alexander A. (San Diego CA) Hammond Philip W. (San Diego CA), Proteted chemiluminescent labels.
  297. Ishihara Narihito,JPX ; Yoshida Kiyofumi,JPX ; Hayashi Hidechika,JPX, Reaction apparatus for automatic analysis.
  298. Sucholeiki Irving, Reaction plenum with magnetic separation and/or ultrasonic agitation.
  299. Horner Glenn A. ; Johnson Shirley J. ; Schneider Robert E. ; Smith Robert J. ; Tseo Gus, Reaction receptacle apparatus.
  300. Horner, Glenn A.; Johnson, Shirley J.; Schneider, Robert E.; Smith, Robert J.; Tseo, Gus, Reaction receptacle apparatus.
  301. Horner, Glenn A.; Johnson, Shirley J.; Schneider, Robert E.; Smith, Robert J.; Tseo, Gus, Reaction receptacle apparatus.
  302. Clark Frederic L. (Plano TX) Moore Larry W. (Plano TX) Kanewske ; III William J. (Pleasanton CA) McDowell Douglas D. (Wildwood IL) Clift Gilbert (Mesquite TX), Reaction vessel.
  303. Kedar Haim, Reaction vessel agitation apparatus.
  304. Lewis Scott C. ; Whitesel Mary Beth, Reagent container for automated analyzer.
  305. Kelln Norman G. (Spokane WA) Tiffany Thomas O. (Spokane WA), Reagent handling.
  306. Grandone Cass J. (Lake Forest IL) Zuck Gary L. (Prospect Heights IL) Herchenbach Stephen L. (Grayslake IL) Tyranski James T. (Oakwood Hills IL) Nelson Robert J. (Highland Park IL), Reagent pack for immunoassays.
  307. Warner Brian D. (Martinez CA) Nordell Benjamin T. (Belmont CA) Richardson Bruce J. (Los Gatos CA) El-Hage Amer (Menlo Park CA), Releasable multiwell plate cover.
  308. Andersson, Per; Ekstrand, Gunnar, Retaining microfluidic microcavity and other microfluidic structures.
  309. Dunn, Chadwick M.; Grandone, Cass J.; Herchenbach, Stephen L; Nelson, Robert J.; Tyranski, James T.; Zuck, Gary L., Retrofit kit for changing single immunoassay instrument to flexible multiple immunoassay instrument.
  310. Seaton William Ernest (Chesterfield MO) Shine David B. (University City MO) Drager Craig (Ballwin MO), Sample card transport method for biological sample testing machine.
  311. Marker Edwin M. (Chicago IL) Thacker Paul F. (Wauconda IL) Knopfhart Peter K. (Libertyville IL), Sample ring for clinical analyzer network.
  312. Mendoza Daniel F. (Silver Spring MD) Hodgson Charles E. (Silver Spring MD), Sample transfer arm assembly.
  313. Tayi Apparao, Scheduling operation of an automated analytical system.
  314. Tayi Apparao (Grayslake IL), Scheduling operation of an automated analytical system.
  315. Livak Kenneth J. ; Flood Susan J.A. ; Marmaro Jeffrey ; Mullah Khairuzzaman Bashar, Self-quenching fluorescence probe.
  316. Heinonen Aarne (Turku FIX) Hietanen Hannu (Turku FIX), Shaker/incubator.
  317. Kerr Alexander F. (Yorktown NY) Mernyk Edwin H. (Tarrytown NY) Zabetakis George E. (Bethel CT) Escoli Uri (Teaneck NJ), Slide analysis system.
  318. Helwig Gunter,DEX ; Malin Cosmas,LIX, Storage device for objects, storage station and air-conditioned cabinet.
  319. Ohtani Masami,JPX ; Imanishi Yasuo,JPX ; Tsuji Masao,JPX ; Kawamoto Takanori,JPX ; Iwami Masaki,JPX ; Nishimura Joichi,JPX ; Morita Akihiko,JPX, Substrate processing apparatus, substrate transport apparatus and substrate transfer apparatus.
  320. Hasebe Keizo,JPX ; Nagashima Shinji,JPX ; Semba Norio,JPX ; Akimoto Masami,JPX ; Kimura Yoshio,JPX ; Iida Naruaki,JPX ; Harada Kouji,JPX ; Ueda Issei,JPX ; Konishi Nobuo,JPX, Substrate processing system.
  321. Ueyama Tsutomu (Kyoto JPX) Adachi Hideki (Kyoto JPX) Matsumura Yoshio (Hikone JPX) Tanaka Yasuhide (Kyoto JPX), Subtrate processing apparatus and device for and method of exchanging substrate in substrate processing apparatus.
  322. Clark Frederic L. (Plano TX) Martin Richard R. (Irving TX) Walker Donny R. (Coppell TX), Syringe with bubble flushing.
  323. Ginsberg Guenter (Miami FL) Horne Thomas (Harpenden GB2), System and program for chemical reaction observation with a moving photometer.
  324. Mullis Kary B. (LaJolla CA) Johnson Larry (San Jose CA) Leath Richard A. (Berkley CA) Wennberg Timothy J. (Mariposa CA) Mezei Louis M. (Madison WI) Widunas Joseph T. (Freemont CA), System for automated performance of the polymerase chain reaction.
  325. Berndt Klaus W. (Stewartstown PA), System for detecting bacterial growth in a plurality of culture vials.
  326. Degenhardt Volker (Bensheim DEX) Bohm Manfred (Mannheim DEX) Rainer Alois (Munchen DEX) Wohland Albert (Viernheim DEX), System for incubating sample liquids.
  327. Reichler Allen S. (Owing Mills MD) Antol David J. (Baldwin MD) Lamos Michael L. (Westminster MD) Bourdelle Peter A. (Glen Rock PA) Hildebrand Scott D. (Red Lion PA), System for nucleic acid based diagnostic assay.
  328. Bienhaus Gerhard,DEX ; Lange Hans,DEX, System for opening closures of vessels and for the contamination-free operation of reaction sequences.
  329. Woudenberg Timothy M. ; Bodner Kevin S. ; Connell Charles R. ; Ganz Alan M. ; McBride Lincoln J. ; Saviano Paul G. ; Shigeura John ; Tracy David H. ; Young Eugene F. ; Lee Linda G., System for real time detection of nucleic acid amplification products.
  330. Bienhaus Gerhard,DEX ; Schubert Ulrich,DEX ; Kolb Uwe,DEX ; Stolz Burkhard,DEX ; Pasch Manfred,DEX, System for releasing and isolating nucleic acids.
  331. Bienhaus, Gerhard; Schubert, Ulrich; Kolb, Uwe; Stolz, Burkhard; Pasch, Manfred, System for releasing and isolating nucleic acids.
  332. Macho Heinz,DEX ; Bienhaus Gerhard,DEX, System for the temperature adjustment treatment of liquid samples.
  333. Collins Mark L. ; Halbert Donald N. ; King Walter ; Lawrie Jonathan M., Target and background capture methods with amplification for affinity assays.
  334. Mark L. Collins ; Donald N. Halbert ; Walter King ; Jonathan M. Lawrie, Target and background capture methods with amplification for affinity assays.
  335. Coy Richard A. (Grass Lake MI) Waycaster Roy A. (Tecumseh MI), Temperature control apparatus.
  336. Devaney ; Jr. Mark J. (Eastman Kodak Co. Rochester NY 14650-2201) Wellman Jeffrey A. (Eastman Kodak Co. Rochester NY 14650-2201) Lercher John S. (Eastman Kodak Co. Rochester NY 14650-2201), Temperature control device and reaction vessel.
  337. Kureshy Fareed (Westwood MA) Singh Shailendra (Sharon MA) Webber Gary L. (Sharon MA), Temperature controlled chamber for diagnostic analyzer.
  338. Royer Garfield P. (Elburn IL) Morrison Larry E. (Glen Ellyn IL) Cruickshank Kenneth A. (Naperville IL), Template-directed photoligation.
  339. Strodtbeck Timothy A. ; Molebash John S. ; Hayes Bruce L. ; Smith Rex A. ; Davis Shawn D., Thermal conditioning apparatus.
  340. Moser Rolf,CHX ; Birrer Lukas,CHX, Thermal cycler.
  341. Danssaert John L. (San Diego CA) Shopes Robert J. (San Diego CA) Shoemaker Daniel D. (Stanford CA), Thermal cycler including a temperature gradient block.
  342. Danssaert John Lewis ; Shopes Robert James ; Shoemaker Daniel Davis, Thermal cycler including a temperature gradient block.
  343. Ammann, Kelly G., Transport mechanism.
  344. Kuster Martin (Eschenbach CHX) Forster Marco (Grueningen CHX), Transport system for fluid analysis instrument.
  345. Weisburg William G. ; Shaw Jay H. ; Becker Michael M. ; Majlessi Mehrdad, Two-step hybridization and capture of a polynucleotide.
  346. Bloch Will (El Cerrito CA) Raymond Jonathan (Oakland CA) Read Alan R. (Alameda CA), Use of grease or wax in the polymerase chain reaction.
  347. Collier Charles F. (Wilmington DE) Riall James D. (Elkton MD), Vortex mixer drive.
  348. Bilbrey Robert A. (Orinda CA), Vortexer.
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