Methods of inhibiting a bacterial virulence in a subject
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-036/22
A61K-031/7034
A61K-045/06
A61K-031/352
A61K-031/7028
A61K-036/82
A61K-031/7048
A61K-031/353
A61K-031/192
A61K-031/185
A61K-033/40
A61K-036/185
출원번호
US-0199075
(2016-06-30)
등록번호
US-9603883
(2017-03-28)
발명자
/ 주소
Huang, Alexander L
Wu, Gin
출원인 / 주소
LIVELEAF, INC.
대리인 / 주소
Boyer, Brian S.
인용정보
피인용 횟수 :
2인용 특허 :
77
초록▼
Methods of inhibiting bacterial virulence in a subject are provided. The methods can include administering an effective amount of a formulation to inhibit a bacterial virulence in a subject, the formulation having a water soluble tannin combined with hydrogen peroxide in a pharmaceutically acceptabl
Methods of inhibiting bacterial virulence in a subject are provided. The methods can include administering an effective amount of a formulation to inhibit a bacterial virulence in a subject, the formulation having a water soluble tannin combined with hydrogen peroxide in a pharmaceutically acceptable excipient; wherein, the tannin has a molecular weight ranging from about 170 Daltons to about 4000 Daltons; the tannin:peroxide weight ratio ranges from about 1:1000 to about 10:1; and, the composition inhibits a bacterial virulence in the subject when compared to a second subject in a control group in which the composition was not administered.
대표청구항▼
1. A method of inhibiting gastrointestinal spasm associated with a bacterial virulence in a subject, the method comprising: administering an effective amount of a formulation to inhibit a bacterial virulence in the subject, the formulation having a water soluble tannin combined with hydrogen peroxid
1. A method of inhibiting gastrointestinal spasm associated with a bacterial virulence in a subject, the method comprising: administering an effective amount of a formulation to inhibit a bacterial virulence in the subject, the formulation having a water soluble tannin combined with hydrogen peroxide in a pharmaceutically acceptable excipient;wherein,the tannin has a molecular weight ranging from about 170 Daltons to about 4000 Daltons;the tannin:peroxide weight ratio ranges from about 1:1000 to about 10:1; and,the composition inhibits gastrointestinal spasm associated with a bacterial virulence in the subject when compared to a second subject in a control group in which the composition was not administered. 2. The method of claim 1, wherein the tannin is a hydrolysable tannin. 3. The method of claim 1, wherein the tannin is a water soluble condensed tannin. 4. The method of claim 1, wherein the tannin is a mixture of a hydrolysable tannin and a water soluble condensed tannin. 5. The method of claim 1, wherein the tannin is a flavanol. 6. The method of claim 1, wherein the tannin is a catechin. 7. The method of claim 1, wherein the tannin is gallic acid, epigallic acid, or a combination thereof. 8. The method of claim 1, wherein the tannin is a gallotannin. 9. The method of claim 1, wherein the tannin is an ellagitannin. 10. The method of claim 1, wherein the tannin is a punicalagin. 11. The method of claim 1, wherein the tannin is combined with the hydrogen peroxide as a component of a water extract of a plant tissue. 12. The method of claim 1, wherein the tannin is combined with the hydrogen peroxide as a component of an alcohol extract of a plant tissue. 13. The method of claim 2, wherein the hydrolysable tannin is a product of a water extraction of Chinese gall. 14. The method of claim 1, wherein the tannin is a hydrolysable tannin having from 3-12 galloyl residues. 15. A method of inhibiting gastrointestinal spasm associated with a bacterial virulence in a subject, comprising: administering an effective amount of a composition to a subject to inhibit a bacterial virulence; the formulation produced from a process includingcombining a water soluble tannin with hydrogen peroxide at a tannin:peroxide weight ratio that ranges from about 1:1000 to about 10:1, the tannin having a molecular weight ranging from about 170 Daltons to about 4000 Daltons;removing free hydrogen peroxide from the combination; and, mixing the combination of the tannin and the hydrogen peroxide with a pharmaceutically acceptable excipient to create the formulation;wherein,the administering includes selecting a desired concentration of the formulation for the administering; and,the composition inhibits gastrointestinal spasm associated with a bacterial virulence in the subject when compared to a second subject in a control group in which the composition was not administered. 16. The method of claim 15, wherein the tannin is a hydrolysable tannin. 17. The method of claim 15, wherein the tannin is a water soluble condensed tannin. 18. The method of claim 15, wherein the tannin is a mixture of a hydrolysable tannin and a water soluble condensed tannin. 19. The method of claim 15, wherein the tannin is a flavanol. 20. The method of claim 15, wherein the tannin is a catechin. 21. The method of claim 15, wherein the tannin is gallic acid, epigallic acid, or a combination thereof. 22. The method of claim 15, wherein the tannin is a gallotannin. 23. The method of claim 15, wherein the tannin is an ellagitannin. 24. The method of claim 15, wherein the tannin is a punicalagin. 25. The method of claim 15, wherein the tannin is combined with the hydrogen peroxide as a component of a water extract of a plant tissue. 26. The method of claim 15, wherein the tannin is combined with the hydrogen peroxide as a component of an alcohol extract of a plant tissue. 27. A method of inhibiting gastrointestinal spasm associated with a bacterial virulence in a subject, the method comprising: administering an effective amount of a composition to a subject to inhibit a bacterial virulence in the subject, the composition having a water soluble polyphenol that was (i) water-extracted from pomegranate husk and green tea leaf and (ii) combined with hydrogen peroxide prior to the administering;wherein, the hydrogen peroxide concentration ranges from about 0.001% to about 2.0% based on total dry weight of the composition;the polyphenol comprises a tannin;the polyphenol has a molecular weight ranging from about 170 Daltons to about 4000 Daltons; and,the composition inhibits gastrointestinal spasm associated with a bacterial virulence in the subject when compared to a second subject in a control group in which the composition was not administered. 28. A method of inhibiting gastrointestinal spasm associated with a bacterial virulence in a subject, comprising: administering an effective amount of a composition to inhibit a bacterial virulence in the subject,the composition produced from a process including extracting a water soluble polyphenol from a combination of green tea leaf and pomegranate husk;combining the polyphenol with hydrogen peroxide prior to the administering;wherein, the polyphenol has a molecular weight ranging from about 170 Daltons to about 4000 Daltons;selecting a desired concentration for the composition; and,diluting the composition to the desired concentration for the administering;wherein, the hydrogen peroxide concentration ranges from about 0.001% to about 2.0% based on total dry weight of the composition;the polyphenol comprises a tannin; and,the composition inhibits gastrointestinal spasm associated with a bacterial virulence in the subject when compared to a second subject in a control group in which the composition was not administered.
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