Personalizing substance for application to the skin or addition to tattoo ink and methods of preparation thereof
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-008/02
A61K-008/11
A61K-008/60
A61K-008/81
A61Q-001/02
출원번호
US-0593409
(2015-01-09)
등록번호
US-9610229
(2017-04-04)
발명자
/ 주소
Duffy, Patrick
Jorgensen, Ellen Dias
Boger, Erich
Mathiowitz, Edith
출원인 / 주소
Chamber Works, LLC
대리인 / 주소
McCarter & English, LLP
인용정보
피인용 횟수 :
0인용 특허 :
8
초록▼
Compositions for delivering materials, such as a biological material, sand, soil, metal, water, sea water, holy water, synthetic or biological polymers, cremated ash, ceramics, animal or plant tissue, or another physiologically compatible component having personal significance to an individual are d
Compositions for delivering materials, such as a biological material, sand, soil, metal, water, sea water, holy water, synthetic or biological polymers, cremated ash, ceramics, animal or plant tissue, or another physiologically compatible component having personal significance to an individual are described herein. The material(s) are encapsulated in an inert, non-bioerodible, hydrophobic, polymeric material. Methods of making microparticles encapsulating the personalizing substance and methods of use are also provided. The personalizing substance may be encapsulated in a polymeric non-bioerodible microparticle. The encapsulated personalizing substance may be combined with a carrier for delivery to an individual's skin. In some embodiments, the personalizing substance is added to a tattoo ink and incorporated in a tattoo created on an individual's skin. Following injection in the skin, the encapsulated material remains in the microparticles, and is not released over time.
대표청구항▼
1. A composition comprising DNA encapsulated in a non-bioerodible, polymeric microparticle, wherein: (a) the microparticle comprises a biocompatible, hydrophobic, non-bioerodible polymer;(b) the microparticle does not comprise silica;(c) the microparticle does not release a detectable amount of the
1. A composition comprising DNA encapsulated in a non-bioerodible, polymeric microparticle, wherein: (a) the microparticle comprises a biocompatible, hydrophobic, non-bioerodible polymer;(b) the microparticle does not comprise silica;(c) the microparticle does not release a detectable amount of the DNA for at least one year after delivery to an individual's skin; and(d) the microparticle comprises up to 0.01% (w/w) DNA. 2. The composition of claim 1, further comprising a carrier suitable for injection into the skin. 3. The composition of claim 1, wherein the DNA is in the form of nanoparticles. 4. The composition of claim 1, wherein the DNA comprises a personal identification characteristic selected from the group consisting of short tandem repeats (STRs), single nucleotide polymorphisms (SNPs), epigenetic markers, and methylated DNA. 5. The composition of claim 1, wherein the polymer is selected from the group consisting of polyvinyl acetate, polyacrylate, polymethacrylate, and copolymers and blends thereof. 6. The composition of claim 1, wherein the polymer has a glass transition temperature that is greater than or equal to 60° C. or has a melting point greater than or equal to 50° C. 7. The composition of claim 1, further comprising a tattoo ink, wherein the ink comprises at least one pigment or dye. 8. The composition of claim 1, wherein the DNA is not used for the purpose of multiplying or expressing the genetic information contained within it. 9. The composition of claim 1, wherein the microparticle does not comprise visible pores using scanning electron microscopy (SEM). 10. The composition of claim 1, wherein the DNA is isolated from an organism. 11. The composition of claim 1, wherein the DNA does not comprise a vector. 12. A composition comprising DNA encapsulated in a non-bioerodible, polymeric microparticle, wherein: (a) the microparticle comprises a biocompatible, hydrophobic, non-bioerodible polymer;(b) the microparticle does not comprise visible pores using scanning electron microscopy (SEM);(c) the microparticle does not release a detectable amount of the personalizing substance for at least one year after delivery to an individual's skin; and(d) the microparticle comprises up to 0.01% (w/w) DNA. 13. The composition of claim 12, wherein the microparticle does not comprise silica. 14. The composition of claim 12, wherein the DNA is not used for the purpose of multiplying or expressing the genetic information contained within it. 15. The composition of claim 12, wherein the DNA is isolated from an organism. 16. The composition of claim 12, wherein the DNA does not comprise a vector. 17. The composition of claim 12, further comprising a carrier suitable for injection into the skin. 18. The composition of claim 12, wherein the DNA is in the form of nanoparticles. 19. The composition of claim 12, wherein the polymer is selected from the group consisting of polyvinyl acetate, polyacrylate, polymethacrylate, and copolymers and blends thereof. 20. The composition of claim 12, further comprising a tattoo ink, wherein the ink comprises at least one pigment or dye.
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