Layered collagen and HA scaffold suitable for osteochondral repair
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61L-015/28
A61F-002/02
A61L-015/32
A61L-027/24
A61L-027/42
A61L-027/46
A61L-027/56
A61L-027/20
A61L-027/26
A61L-027/12
A61L-027/36
A61L-027/38
C12N-005/077
출원번호
US-0725337
(2015-05-29)
등록번호
US-9615910
(2017-04-11)
우선권정보
EP-09151226 (2009-01-23)
발명자
/ 주소
Gleeson, John P.
Levingstone, Tanya J.
O'Brien, Fergal J.
출원인 / 주소
ROYAL COLLEGE OF SURGEONS IN IRELAND
대리인 / 주소
Nixon Peaobdy LLP
인용정보
피인용 횟수 :
0인용 특허 :
14
초록▼
The invention relates to a method for producing a multi-layer collagen scaffold. The method generally comprises the steps of: preparing a first suspension of collagen and freezing or lyophilizing the suspension to provide a first layer; optionally preparing a further suspension of collagen and addin
The invention relates to a method for producing a multi-layer collagen scaffold. The method generally comprises the steps of: preparing a first suspension of collagen and freezing or lyophilizing the suspension to provide a first layer; optionally preparing a further suspension of collagen and adding the further suspension onto the layer formed in the previous step to form a further layer, and freezing or lyophilizing the layers, wherein when the layer formed in the previous step is formed by lyophilization the lyophilized layer is re-hydrated prior to addition of the next layer; optionally, repeating the aforementioned step to form one or more further layers; and preparing a final suspension of collagen and pouring the final suspension onto the uppermost layer to form a final layer, and freeze-drying the layers to form the multi-layer collagen composite scaffold.
대표청구항▼
1. A method of repairing a bone or cartilage defect in a mammal, comprising the steps of providing a multi-layer collagen scaffold, shaping the scaffold to fit into the defect, and inserting the scaffold into the defect, wherein the multi-layer collagen scaffold comprises a three freeze-dried layers
1. A method of repairing a bone or cartilage defect in a mammal, comprising the steps of providing a multi-layer collagen scaffold, shaping the scaffold to fit into the defect, and inserting the scaffold into the defect, wherein the multi-layer collagen scaffold comprises a three freeze-dried layers in which a first layer comprises Type I collagen and HA, a second layer comprises Type I collagen and a Type II collagen and HA, and a third layer comprises Type I and Type II collagen and a polymer and/or biologic. 2. The method of claim 1, further comprising incorporating a biologic into the scaffold, either before or after shaping. 3. The method of claim 2, wherein the biologic is selected from the group consisting of: a nucleic acid; a protein; a peptide; a cytokine; a hormone; a cell; and a growth factor. 4. The method of claim 1, wherein the scaffold has a base layer comprising collagen and HA, and wherein the scaffold is inserted into the defect such that the base layer abuts the deepest part of the defect. 5. The method of claim 1, wherein the tissue defect is selected from the group consisting of: osteochondral defects; cardiovascular defects; mandibular/maxillofacial defects; tracheal reconstruction; cartilage defect repair within an articulating joint within the skeletal system; soft tissue defect within the body; cartilage damage due to an arthritis; collateral damage at articulating joints due to trauma; ankle joint defects; and soft tissue reconstruction. 6. The method of claim 5, wherein the articulating joint within the skeletal system is hip, knee, shoulder, ankle, hand, foot, neck, or spine. 7. The method of claim 5, wherein the collateral damage at articulating joints due to trauma is anterior cruciate Ligament, torn rotator cuff, dislocated/broken ankle, or meniscal repair. 8. The method of claim 5, wherein the soft tissue reconstruction is maxillofacial or tissue augmentation. 9. A method of claim 1, wherein: (i) the multi-layer collagen scaffold has a continuous pore architecture extending across the layers, and in which the pore architecture of at least two of the layers is typically different; or(ii) The multi-layer collagen scaffold wherein the interface between each layer is seamless, and in which the pore architecture of at least two of the layers is typically different; or(iii) the multilayer collagen scaffold comprises continuous physical integration at the interface of each adjacent layer and wherein each layer comprises a pore architecture characteristic that is different to the other layers. 10. The method of claim 1, wherein a ratio of HA in the first layer to HA in the second layer is at least 1:1 (w/w).
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