Sulfhydryl-functionalized polymeric compositions for medical devices
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61L-026/00
A61L-015/26
A61L-015/42
C08G-018/50
C08G-018/83
C08G-018/38
A61F-013/00
A61M-001/00
C08G-101/00
A61N-001/04
출원번호
US-0438493
(2013-10-24)
등록번호
US-9616151
(2017-04-11)
국제출원번호
PCT/US2013/066683
(2013-10-24)
국제공개번호
WO2014/066684
(2014-05-01)
발명자
/ 주소
Hanson, Douglas Philip
Courage, James
출원인 / 주소
KCI Licensing, Inc.
대리인 / 주소
Harness, Dickey & Pierce, P.L.C.
인용정보
피인용 횟수 :
0인용 특허 :
87
초록▼
The present disclosure provides sulfhydryl-modified polymer foams, which may be used for wound dressing materials. For example, the modified materials can include free sulfhydryl group, which can serve as a linker to attach biologically active molecules. For example, sulfhydryl groups can be used to
The present disclosure provides sulfhydryl-modified polymer foams, which may be used for wound dressing materials. For example, the modified materials can include free sulfhydryl group, which can serve as a linker to attach biologically active molecules. For example, sulfhydryl groups can be used to conjugate biologically active polypeptides and/or metals to foam polymers. Methods for using sulfhydryl-modified polymers, such as for wound dressings, are also provided.
대표청구항▼
1. An open cell foam comprising a sulfhydryl-functional polyurethane polymer comprising a sulfhydryl group available for chemical reaction wherein the sulfhydryl group is provided by an adapter covalently attached to the polyurethane polymer, wherein the adapter has the structure of formula (I): whe
1. An open cell foam comprising a sulfhydryl-functional polyurethane polymer comprising a sulfhydryl group available for chemical reaction wherein the sulfhydryl group is provided by an adapter covalently attached to the polyurethane polymer, wherein the adapter has the structure of formula (I): wherein one or both of R1 and R2 forms a first covalent bond with the material and the other is OH, OCH3, O(CH2)1-4)CH3, or a covalent bond with the polymer; n is 1-30; and R3 is H, further comprising a biologically active agent covalently attached to the sulfhydryl group or through a disulfide group derived from the sulfhydryl group. 2. The open cell foam of claim 1, further comprising a crosslinker covalently attached to the adapter. 3. The open cell foam of claim 2, further comprising a biologically active agent covalently attached to the crosslinker. 4. The open cell foam of claim 1, wherein the biologically active agent is a therapeutic agent selected from the group consisting of a peptide, polypeptide, peptide matrix, protein matrix, carbohydrate, oligonucleotide, antimicrobial, small molecule, nanoparticle, nanobot, aliphatic hydrocarbon chain, surfactants, alginate, aptamer, and a combination thereof. 5. The open cell foam of claim 1, wherein the biologically active agent comprises a metal cation in the +1, or +2 state. 6. The open cell foam of claim 1, wherein the biologically active agent is a therapeutic agent selected from the group consisting of a peptide, polypeptide, peptide matrix, protein matrix, carbohydrate, oligonucleotide, antimicrobial, small molecule, nanoparticle, nanobot, aliphatic hydrocarbon chain, surfactants, alginate, aptamer, and a combination thereof. 7. The open cell foam of claim 2, wherein the biologically active agent is a therapeutic agent selected from the group consisting of a peptide, polypeptide, peptide matrix, protein matrix, carbohydrate, oligonucleotide, antimicrobial, small molecule, nanoparticle, nanobot, aliphatic hydrocarbon chain, surfactants, alginate, aptamer, and a combination thereof. 8. A wound dressing comprising the foam of claim 1. 9. A method for treating a wound comprising contacting a wound site with a wound dressing of claim 1. 10. The method of claim 9, wherein the method further comprises applying negative pressure to the wound site. 11. The method of claim 10, wherein the method further comprises applying wound instillation solution to the wound site. 12. The method of claim 11, wherein the instillation solution includes one or more agents that modulate the release of the biologically active agent.
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이 특허에 인용된 특허 (87)
Ward William J. (Hull GBX) Shorthouse Joanne (Hull GBX), Adhesive dressing for retaining a cannula on the skin.
Heifetz Aaron H. (Columbia MD) Wolfe Richard A. (Ellisville MO) Braatz James A. (Beltsville MD) Luthra Narender P. (Columbia MD), Cell growth enhancers and/or antibody production stimulators comprising chemically modified hydrophilic polyurea-urethan.
Errede Louis A. (North Oaks MN) Stoesz James D. (St. Paul MN) Winter ; deceased George D. (late of St. Paul MN by Jenny Upton ; personal representative), Composite wound dressing.
Todd Robert J. (Salt Lake City UT) Yagge Jaime E. (Salt Lake City UT) Lowe James E. (Durham NC) Wonder Terry M. (Salt Lake City UT), Medical suction apparatus.
Ferdman Ariel (12 Hillside Ave. Melrose MA 02176) Kuo Jing-wen (Boxboro MA) Miller David (Brookline MA) Pinsky Vladimir (Brighton MA) Richards William D. (Medway MA) Swann David (Cambridge MA), Method and device for wound closure.
Moriuchi Yousuke (Fujinomiya JPX) Ishida Toshinobu (Fujinomiya JPX) Kousai Tadashi (Fujinomiya JPX), Method of securing a catheter body to a human skin surface.
Luheshi Abdul B. N. (Hull GB3) Smalley Robert K. (Urmston GB3) Kennewell Peter D. (Okus GB3) Westwood Robert (Kingston Bagpuize GB3), Process for the preparation of azabicyclo compounds.
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