In various embodiments, an implantable pump includes a cannula. The pump (e.g., the cannula thereof) may include, for example, flow sensors, pressure sensors, filters, and/or other components.
대표청구항▼
1. An implantable pump, comprising: a drug reservoir chamber and an electrolyte chamber surrounded, at least in part, by a wall comprising parylene and separated from each other by an expandable parylene diaphragm, the diaphragm forming a lower boundary of one of the chambers and an upper boundary o
1. An implantable pump, comprising: a drug reservoir chamber and an electrolyte chamber surrounded, at least in part, by a wall comprising parylene and separated from each other by an expandable parylene diaphragm, the diaphragm forming a lower boundary of one of the chambers and an upper boundary of the other chamber, the electrolyte chamber including an electrolyte liquid therein;a cannula, made at least in part from parylene, for conducting liquid from the drug reservoir chamber;electrolysis electrodes for causing, in response to a current supplied thereto, evolution of a gas in the electrolyte chamber to thereby expand the diaphragm from a space-efficient corrugated configuration having a first surface area of contact with the electrolyte liquid to an expanded configuration having a second surface area of contact with the electrolyte liquid wherein the first surface area being greater than the second surface area, so as to force the liquid from the drug reservoir through the cannula, whereby following cessation of the current, the diaphragm recovers the space-efficient corrugated configuration and re-establishes the first surface area of contact with the electrolyte liquid without reducing a volume of the drug reservoir chamber;a sensor, made at least in part from parylene, for monitoring at least one of a flow rate of liquid flowing through the cannula or a pressure inside the implantable pump; andcircuitry for adjusting delivery of the liquid through the cannula by controlling, in response to the sensor, the electrolysis electrodes so as to vary an amount of liquid forced from the drug reservoir chamber. 2. The pump of claim 1, wherein the sensor is electrically connected to the circuitry via metal lines running along the cannula. 3. The pump of claim 1, wherein the sensor is a flow sensor. 4. The pump of claim 3, wherein the flow sensor is a thermal flow sensor. 5. The pump of claim 4, wherein the flow sensor comprises a single element, physically associated with the cannula, that functions both as a heater and as a temperature sensor. 6. The pump of claim 4, wherein the flow sensor comprises a heater and a temperature sensor, both physically associated with the cannula, the temperature sensor being located downstream of the heater. 7. The pump of claim 4, wherein the flow sensor comprises a heater and first and second temperature sensors, all physically associated with the cannula, the first temperature sensor being located downstream of the heater and the second temperature sensor being located upstream of the heater. 8. The pump of claim 3, wherein the flow sensor is a time-of-flight sensor. 9. The pump of claim 8, wherein the flow sensor comprises a heater and a temperature sensor, both physically associated with the cannula, the temperature sensor being located downstream of the heater, and wherein the circuitry causes a discrete pulse of power to be applied to the heater and detection, by the temperature sensor, of liquid heated by the heater. 10. The pump of claim 9 further comprising a second temperature sensor physically associated with the cannula and located upstream of the heater. 11. The pump of claim 9 further comprising at least a second temperature sensor physically associated with the cannula and located downstream of the heater. 12. The pump of claim 8, wherein the flow sensor comprises two upstream electrodes and two downstream electrodes, each physically associated with the cannula, and wherein the circuitry causes a discrete voltage pulse to be applied across the two upstream electrodes and detection, by the two downstream electrodes, of an electrochemical pulse generated in the liquid flowing through the cannula. 13. The pump of claim 3, wherein the flow sensor comprises a pressure sensor in the reservoir. 14. The pump of claim 3, wherein the flow sensor comprises at least one pressure sensor in the cannula. 15. The pump of claim 3 further comprising a temperature sensor not in proximity to the flowing liquid for facilitating compensation for fluctuations in an ambient temperature. 16. The pump of claim 1, wherein the sensor is a pressure sensor. 17. The pump of claim 16 further comprising a check valve in the cannula, the pressure sensor being located inside the cannula and downstream of the check valve. 18. The pump of claim 16, wherein the circuitry detects a pump malfunction based on the monitored pressure. 19. The pump of claim 18, wherein the pressure sensor is placed in the drug reservoir or in proximity to an interface between the cannula and the drug reservoir. 20. The pump of claim 16 further comprising a flow sensor for monitoring a flow rate of the liquid. 21. The pump of claim 20, wherein the circuitry detects a pump malfunction based on the monitored pressure and flow. 22. The pump of claim 1, further comprising a pressure sensor located at a distal end of the cannula for measuring pressure at the target site. 23. The pump of claim 22, wherein the circuitry adjusts pump operation based on monitored pressure at the target site. 24. The pump of claim 22, wherein the pressure sensor is inside the cannula. 25. The pump of claim 22, wherein the pressure sensor is outside the cannula. 26. The pump of claim 1, wherein the circuitry is configured to adjust, based on the monitored flow rate and/or pressure, a dosing schedule and a volume of the liquid delivered by the pump. 27. The pump of claim 1, wherein the diaphragm recovers the space-efficient corrugated configuration when the gas in the electrolyte chamber condenses back into a liquid state.
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