A process for capturing or concentrating microorganisms for detection or assay comprises (a) providing a concentration agent that comprises an amorphous metal silicate and that has a surface composition having a metal atom to silicon atom ratio of less than or equal to about 0.5, as determined by X-
A process for capturing or concentrating microorganisms for detection or assay comprises (a) providing a concentration agent that comprises an amorphous metal silicate and that has a surface composition having a metal atom to silicon atom ratio of less than or equal to about 0.5, as determined by X-ray photoelectron spectroscopy (XPS); (b) providing a sample comprising at least one microorganism strain; and (c) contacting the concentration agent with the sample such that at least a portion of the at least one microorganism strain is bound to or captured by the concentration agent.
대표청구항▼
1. A process comprising: (a) providing an inorganic concentration agent that comprises an amorphous, spheroidized metal silicate formed from melted or softened metal silicate feed particles and that has a surface composition having a metal atom to silicon atom ratio of less than or equal to 0.5, as
1. A process comprising: (a) providing an inorganic concentration agent that comprises an amorphous, spheroidized metal silicate formed from melted or softened metal silicate feed particles and that has a surface composition having a metal atom to silicon atom ratio of less than or equal to 0.5, as determined by X-ray photoelectron spectroscopy (XPS), wherein said metal is selected from magnesium, calcium, zinc, aluminum, iron, titanium, and combinations thereof;(b) providing a sample comprising at least one microorganism strain;(c) contacting said concentration agent with said sample such that at least a portion of said at least one microorganism strain is bound to or captured by said inorganic concentration agent;(d) segregating the resulting microorganism-bound inorganic concentration agent, wherein said segregating is affected by a method selected from gravitational settling, centrifugation, and combinations thereof; and(e) separating the resulting segregated microorganism-bound inorganic concentration agent from said sample. 2. The process of claim 1, wherein said inorganic concentration agent is a particulate concentration agent. 3. The process of claim 1, wherein said surface composition has a metal atom to silicon atom ratio of less than or equal to 0.4. 4. The process of claim 1, wherein said inorganic concentration agent has a negative zeta potential at a pH of 7. 5. The process of claim 1, wherein said metal is magnesium. 6. The process of claim 1, wherein said inorganic concentration agent comprises an amorphous metal silicate in at least partially fused particulate form. 7. The process of claim 1, wherein said inorganic concentration agent is amorphous, spheroidized magnesium silicate. 8. The process of claim 1, wherein said sample is in the form of a fluid. 9. The process of claim 1, wherein said microorganism strain is selected from strains of bacteria, fungi, yeasts, protozoans, viruses, bacterial endospores, and combinations thereof. 10. The process of claim 1, wherein said contacting is carried out by mixing said inorganic concentration agent and said sample. 11. The process of claim 1, wherein said process further comprises detecting the presence of at least one bound microorganism strain. 12. The process of claim 11, wherein said detecting is carried out by a method selected from culture-based methods, microscopy and other imaging methods, genetic detection methods, immunologic detection methods, bioluminescence-based detection methods, and combinations thereof.
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