Control of liquid flow sequence on a microfluidic device
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
B01L-003/00
G05D-007/06
출원번호
US-0007257
(2012-03-23)
등록번호
US-9625916
(2017-04-18)
우선권정보
PT-105583 (2011-03-24)
국제출원번호
PCT/IB2012/051411
(2012-03-23)
§371/§102 date
20131226
(20131226)
국제공개번호
WO2012/131556
(2012-10-04)
발명자
/ 주소
Garcia Da Fonseca, João
Reis, Nuno
Tenreiro, Tânia
Pinto Bordeira, Sandro Miguel
출원인 / 주소
Biosurfit, S.A.
대리인 / 주소
Patterson Thuente Pedersen, P.A.
인용정보
피인용 횟수 :
0인용 특허 :
2
초록▼
Described embodiments provide devices, systems and methods for sequencing liquid flow in response to a driving force by entrapping and releasing gas between volumes of liquid in a controlled manner. In one particular form, a centrifugal “lab on a disk” device is provided to drive liquid flow and seq
Described embodiments provide devices, systems and methods for sequencing liquid flow in response to a driving force by entrapping and releasing gas between volumes of liquid in a controlled manner. In one particular form, a centrifugal “lab on a disk” device is provided to drive liquid flow and sequencing by virtue of the centrifugal force and in one particular form a radially inward bend conduit is used in connection with controllably trapping and releasing gas between liquid volumes.
대표청구항▼
1. A device for handling liquid, the device being rotatable about an axis of rotation to drive liquid flow within the device, the device comprising: a first liquid holding structure for receiving a first liquid volume;a second liquid holding structure for receiving a second liquid volume;an upstream
1. A device for handling liquid, the device being rotatable about an axis of rotation to drive liquid flow within the device, the device comprising: a first liquid holding structure for receiving a first liquid volume;a second liquid holding structure for receiving a second liquid volume;an upstream liquid handling structure connected to the first liquid holding structure by a first conduit to supply the first liquid volume to the first liquid holding structure and connected to the second liquid holding structure by a second conduit to supply the second liquid volume to the second liquid holding structure;a third conduit connecting an outlet port of the second liquid holding structure to an inlet port of the first liquid holding structure, the third conduit comprising a bend portion defining a crest radially inward of both the inlet port and the outlet port to trap gas between the first and second liquid volumes; anda downstream liquid handling structure for receiving liquid from a fourth conduit fluidly connected to the first liquid holding structure,wherein the second liquid volume is held in the second liquid holding structure until the first liquid volume is dispensed through the fourth conduit leaving a liquid level of the first liquid volume in the first liquid holding structure at which the trapped gas is vented through the first liquid holding structure and the second liquid volume then flows from the second liquid holding structure to the downstream liquid handling structure through the first liquid holding structure. 2. A device as claimed in claim 1, in which the device is arranged to fill the second liquid holding structure with an amount of liquid not less than the volume of the second liquid holding structure and a portion of the third conduit adjacent the second liquid holding structure, filled to a level radially at an innermost point of the third conduit. 3. A device as claimed in claim 1, in which the device is arranged to fill the second liquid holding structure with an amount of liquid corresponding to a liquid level in the third conduit and second liquid holding structure such that a capillary force, acting on a liquid in the third conduit, is sufficient to draw the liquid across a radially innermost point of the third conduit at a rotational frequency less than a cut-off frequency. 4. A device as claimed in claim 3 wherein the cut-off frequency is 30 Hz. 5. A device as claimed in claim 1, comprising a vent conduit connecting the first and second liquid holding structures to equilibrate pressures therebetween. 6. A device as claimed in claim 1 comprising a further conduit for connecting a further inlet port of the first liquid holding structure to a further outlet port of a third liquid holding structure, the further conduit comprising a further bend portion extending radially inward of the further inlet and outlet ports, thereby enabling gas to be trapped in the further bend portion between respective liquids from the first and third liquid holding structures, wherein the further inlet port is radially outward of the inlet port to hold liquid in the third liquid holding structure while liquid is flowing from the second liquid holding structure through the first liquid holding structure to maintain a liquid level in the first liquid holding structure radially inward the further inlet port. 7. A device as claimed in claim 1, arranged to sequentially move liquid from the first and second liquid holding structures to the downstream liquid handling structure while the device is rotated at a constant rate. 8. A liquid handling system comprising a device as claimed in claim 1 coupled to a motor and a controller coupled to the motor to control rotation of the device to sequentially dispense liquid from the first and second liquid holding structures. 9. A liquid handling system as claimed in claim 8, the controller being operable to rotate the device at a substantially constant frequency, to sequentially dispense liquid from the first and second liquid holding structures. 10. A liquid handling system comprising: means for filling a first liquid holding structure with a first liquid volume and a second liquid holding structure with a second liquid volume, the first liquid volume and the second liquid volume being supplied from an upstream liquid handling structure;means for separating the first liquid volume from the second liquid volume by trapping gas in a bend portion of a conduit fluidly connecting the first and second liquid holding structures, the conduit connecting an outlet port of the second liquid holding structure to an inlet port of the first liquid holding structure with the bend portion being located radially inward of the outlet port and the inlet ports, whereby the gas is trapped between the first and second liquid volumes of the first and second liquid holding structures as the first and second liquid holding structures are filled with the first and second liquid volumes;means for moving the first liquid volume from the first liquid holding structure to a downstream liquid handling structure while the second liquid volume is held in the second liquid holding structure; andmeans for moving the second liquid volume from the second liquid holding structure, through the conduit and the first liquid holding structure to the downstream liquid handling structure, subsequent to venting the trapped gas from the conduit through the first liquid holding structure. 11. A liquid handling system as claimed in claim 10, further comprising: means for filling a third liquid holding structure with a third liquid volume to trap gas in a further conduit between the first and third liquid holding structures;means for moving the first liquid volume and the second liquid volume from the first and second liquid holding structures to the downstream liquid handling structure while the third liquid volume is held in the third liquid holding structure; andmeans for moving the third liquid volume from the third liquid holding structure, through the further conduit and the first liquid holding structure to the downstream liquid handling structure, subsequent to venting the trapped gas from the further conduit through the first liquid holding structure. 12. A liquid handling system as claimed in claim 10, comprising means for moving the first liquid volume and the second liquid volume from the first and second liquid holding structures in response to a substantially constant driving force. 13. A method of sequentially moving liquid from first and second liquid holding structures to a downstream liquid handling structure, the method including: filling the first and second liquid holding structures with first and second liquid volumes respectively from an upstream liquid handling structure, the first and second liquid volumes trapping gas in a bend portion of a conduit between the first and second liquid holding structures, the conduit connecting an outlet port of the second liquid holding structure to an inlet port of the first liquid holding structure with the bend portion being located radially inward of the outlet port and the inlet ports;moving the first liquid volume from the first liquid holding structure to a downstream liquid handling structure while the second liquid volume is held in the second liquid holding structure; andmoving the second liquid volume from the second liquid holding structure, through the conduit and the first liquid holding structure to the downstream liquid handling structure, subsequent to venting the trapped gas from the conduit through the first liquid holding structure. 14. A method as claimed in claim 13, further comprising: filling a third liquid holding structure with a third liquid volume to trap gas in a further conduit between the first and third liquid holding structures;moving the first and second liquid volumes from the first and second liquid holding structures to the downstream liquid handling structure while the third liquid volume is held in the third liquid holding structure; andmoving the third liquid volume from the third liquid holding structure, through the further conduit and the first liquid holding structure to the downstream liquid handling structure, subsequent to venting the trapped gas from the further conduit through the first liquid holding structure. 15. A method as claimed in claim 13, in which the first and second liquid volumes are moved in response to a substantially constant driving force. 16. A device as claimed in claim 1, comprising a first supply conduit connecting an outlet port of the upstream liquid handling structure to an inlet port of the first liquid holding structure and a second supply conduit connecting an outlet port of the upstream liquid handling structure to an inlet of the second liquid holding structure.
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