A polymeric product including at least two layers, wherein a functional layer includes a polymeric material and at least one anti-microbial substance, and a protective layer, including a polymeric material arranged outside the functional layer and completely covering the functional layer, wherein th
A polymeric product including at least two layers, wherein a functional layer includes a polymeric material and at least one anti-microbial substance, and a protective layer, including a polymeric material arranged outside the functional layer and completely covering the functional layer, wherein the protective layer does not include any anti-microbial substances. A method of producing the product, the use of the same and a kit for producing the product.
대표청구항▼
1. An in vivo implant or device for a patient, comprising at least two layers, the at least two layers comprising: a functional layer comprising a polymeric material and at least one anti-microbial substance, andan outer protective layer comprising a polymeric material arranged outside the functiona
1. An in vivo implant or device for a patient, comprising at least two layers, the at least two layers comprising: a functional layer comprising a polymeric material and at least one anti-microbial substance, andan outer protective layer comprising a polymeric material arranged outside the functional layer and completely covering said functional layer,wherein the protective layer does not comprise any anti-microbial substances,the thickness of the protective layer is 1 μm to 30 μm, andwherein during use the protective layer shields the patient from the at least one anti-microbial substance. 2. The in vivo implant or device according to claim 1, wherein the anti-microbial substance in the functional layer is metal nanoparticles. 3. The in vivo implant or device according to claim 1, wherein the polymeric materials in the functional and protective layers are rubber and/or thermoplastic elastomer. 4. The in vivo implant or device according to claim 1, wherein the polymeric material in the functional and protective layers is the same. 5. The in vivo implant or device according to claim 1, wherein the polymeric material in at least one of the functional and protective layers is selected from the group consisting of natural rubber, silicone rubber, isoprene rubber, styrene-butadiene rubber, styrene-ethylene rubber, butadiene rubber, butyl rubber, ethylene-propylene rubber, nitrile rubber, acrylic rubber, chloroprene rubber, fluoro silicone rubber, nitrile butadiene rubber, methyl vinyl silicone rubber, urethane rubber, and combinations thereof. 6. The in vivo implant or device according to claim 1, wherein the polymeric material in at least one of the functional and protective layers is selected from the group consisting of polyester, polyethers, polyamines, polyamides, polyurethanes, polysiloxanes, polypropylenes, polycarbonates, polyacrylates, polyvinyls, polyethylenes, polyimides, polysulfones, polyfenyloxides, polyacetals, polycellulose, polyoleophines, polystyrene, and combinations thereof. 7. A device for in vivo applications, comprising the in vivo implant or device of claim 1, wherein the device is configured to have contact with tissue. 8. The device according to claim 7, wherein the in vivo application is as voice membrane, prostheses, heart valves, joints, lenses, tendons, breast implants, catheters, or as an insulation material. 9. The in vivo implant or device according to claim 1, wherein the thickness of the protective layer is 1 μm to 10 μm. 10. The in vivo implant or device according to claim 1, wherein the functional layer comprises more than 0.01 weight % to 2 weight % of the at least one anti-microbial substance. 11. A method of producing the in vivo implant or device of claim 1, comprising the steps of: a. providing a first polymeric material containing an anti-microbial substance;b. forming a functional layer comprising the first polymeric material;c. optionally curing the functional layer;d. providing, on said functional layer, a protective layer completely covering said functional layer, wherein the protective layer comprising a polymeric material does not comprise any anti-microbial substances;e. optionally curing the protective layer; and optionallyf. repeating step d and e to provide additional layers. 12. The method according to claim 11, wherein the protective layer is provided using dip coating, spin coating, spraying, compression or injection moulding or wherein the protective layer is preformed and then applied on the functional layer. 13. The method according to claim 11, wherein the functional layer is provided using dip coating, spin coating, spraying, extruding, blowing or moulding techniques. 14. The method according to claim 13, wherein the functional layer is formed using injection moulding, compression moulding, injection reaction moulding, transfer moulding, blow moulding, rotational moulding, film blowing, rotational blowing or calendering. 15. The method according to claim 11, wherein the anti-microbial substance is a metal nanoparticle. 16. The method according to claim 11, wherein the anti-microbial substance is a silver and/or copper nanoparticle.
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이 특허에 인용된 특허 (6)
Klemm Klaus (Darmstadt DEX) Wahlig Helmut (Darmstadt DEX), Antibacterial wound dressing.
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