Forschungszentrum Borstel Liebniz-Zentrum fuer Medizin und Biowissenschaften
대리인 / 주소
Whitman, Curtis & Cook, P.C.
인용정보
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0인용 특허 :
9
초록▼
The present invention relates to a method for the ventilation of a living being (3), the respiration airflow (v) flowing into the living being (3) and out of the living being (3) being detected, it being ascertained from the detected respiration airflow (v) whether an inhalation phase or an exhalati
The present invention relates to a method for the ventilation of a living being (3), the respiration airflow (v) flowing into the living being (3) and out of the living being (3) being detected, it being ascertained from the detected respiration airflow (v) whether an inhalation phase or an exhalation phase is present, and the air pressure (p) in a respiratory organ of the living being (3) being regulated, characterized in that, upon recognition of an inhalation phase, the air pressure (p) in the respiratory organ is raised at the beginning of the inhalation phase and lowered again with progressing respiration cycle.
대표청구항▼
1. Method for the ventilation of a living being, performed by a ventilation device, comprising the steps of: detecting a respiration airflow ({dot over (v)}) flowing into the living being and out of the living being,ascertaining from the detected respiration airflow ({dot over (v)}) whether an inhal
1. Method for the ventilation of a living being, performed by a ventilation device, comprising the steps of: detecting a respiration airflow ({dot over (v)}) flowing into the living being and out of the living being,ascertaining from the detected respiration airflow ({dot over (v)}) whether an inhalation phase or an exhalation phase is present,regulating an air pressure (p) in a respiratory organ of the living being,wherein, upon recognition of an inhalation phase in the step of ascertaining, initially raising the air pressure (p) in the respiratory organ at the beginning of the inhalation phase from an initial value of the air pressure (p), which was set at the beginning of the inhalation phase as the starting value (Po), to a predetermined amount, maintaining the air pressure (p) at said predetermined amount during the inhalation phase and into the exhalation phase, and then lowering the air pressure (p) at the end of the exhalation phase to the starting value (Po) and wherein upon recognition of an exhalation phase in the step of ascertaining, raising the air pressure (p) in the respiratory organ at the beginning of the exhalation phase. 2. Method according to claim 1, further comprising the step of increasing the air pressure (p) in the respiratory organ in the exhalation phase to a maximum pressure. 3. Method according to claim 1, further comprising the step of reducing the air pressure (p) in the respiratory organ in the exhalation phase at the end of the exhalation phase according to an essentially exponential decay function. 4. Method according to claim 1, wherein the air pressure (p) in the respiratory organ is only regulated at the beginning of the exhalation phase as detected in the step of ascertaining so that the respiration airflow ({dot over (v)}) flowing out of the living being reaches a predetermined amount. 5. Method according to claim 1, wherein, in the exhalation phase as detected in the step of ascertaining, the air pressure (p) in the respiratory organ is regulated in proportion to the respiration airflow ({dot over (v)}) of the exhalation. 6. Method according to claim 1, wherein tidal volume is ascertained from the detected respiration airflow, further comprising the steps of: increasing the maximum value and/or the pressure level of the air pressure (p) in the respiratory organ in the exhalation phase and/or a pressure curve is adapted if an increase of the tidal volume is established in preceding respiration cycles. 7. Method according to claim 6, wherein the increase of the maximum value and/or the pressure level of the air pressure (p) in the respiratory element in the exhalation phase is limited to a highest value. 8. Method according to claim 1, further comprising the steps of: ascertaining the respiration frequency, andincreasing the maximum value and/or pressure level of the air pressure (p) in the respiratory organ in the exhalation phase, oradapting the pressure curve if a reduction of the respiratory frequency is established in preceding respiration cycles. 9. Method according to claim 1, further comprising the steps of: monitoring a time curve of the air pressure (p) and/or the respiration airflow ({dot over (v)}) in the respiratory organ for an occurrence of a superimposed oscillation having higher frequency than the respiration frequency, andincreasing the maximum value and/or the pressure level of the air pressure (p) in the respiratory organ in the exhalation phase, oradapting the pressure curve if a superimposed oscillation is recognized. 10. Method according to claim 1, further comprising the step of ascertaining an intrinsic PEEP (Positive End Expiratory Pressure-pressure level at the end of the exhalation phase) of the living being from the detected respiration airflow ({dot over (v)}) as a function of the pressure increase in the exhalation phase and the initial value of the air pressure in the respiratory organ (Po), is established in accordance with the intrinsic PEEP. 11. Method according to claim 10, further comprising the step of using the initial value of the air pressure in the respiratory organ as the basal pressure level (pa), which the pressure level does not fall below at any time, a basal pressure level (Po) being established as less than the intrinsic PEEP by a pressure differential value. 12. Method according to claim 1, wherein a regulatory cycle of the air pressure (p) in the respiratory organ comprises at least two respiration cycles, a respiration cycle comprising an inhalation phase and an exhalation phase, which directly follow one another. 13. Ventilation device comprising: at least one controllable air delivery unit,at least one airflow meter,at least one pressure sensor, andat least one programmable control unit receiving inputs from the airflow meter and the pressure sensor, the programmable control unit being set up to control the air delivery unit bydetecting a respiration airflow ({dot over (v)}) flowing into the living being and out of the living being,ascertaining from the detected respiration airflow ({dot over (v)}) whether an inhalation phase or an exhalation phase is present,regulating an air pressure (p) in a respiratory organ of the living being,wherein, upon recognition of an inhalation phase in the step of ascertaining, initially raising the air pressure (p) in the respiratory organ at the beginning of the inhalation from an initial value of the air pressure (p), which was set at the beginning of the inhalation phase as the starting value (Po), to a predetermined amount, maintaining the air pressure (p) at said predetermined amount during the inhalation phase and into the exhalation phase, and then lowering the air pressure (p) at the end of the exhalation phase to the starting value (Po) and wherein upon recognition of an exhalation phase in the step of ascertaining, raising the air pressure (p) in the respiratory organ at the beginning of the exhalation phase. 14. Valve control unit comprising: at least one pressure control valve,at least one airflow meter,at least one pressure sensor, andat least one programmable control unit receiving inputs from the airflow meter and the pressure sensor, the programmable control unit being set up to control an air delivery unit bydetecting a respiration airflow ({dot over (v)}) flowing into the living being and out of the living being,ascertaining from the detected respiration airflow ({dot over (v)}) whether an inhalation phase or an exhalation phase is present,regulating an air pressure (p) in a respiratory organ of the living being,wherein, upon recognition of an inhalation phase in the step of ascertaining, initially raising the air pressure (p) in the respiratory organ at the beginning of the inhalation phase from an initial value of the air pressure (p), which was set at the beginning of the inhalation phase as the starting value (Po), to a predetermined amount, maintaining the air pressure (p) at said predetermined amount during the inhalation phase and into the exhalation phase, and then lowering the air pressure (p) at the end of the exhalation phase to the starting value (Po) and wherein upon recognition of an exhalation phase in the step of ascertaining, raising the air pressure (p) in the respiratory organ at the beginning of the exhalation phase. 15. Method for the ventilation of a living being performed by a ventilation device, comprising the steps of: detecting a respiration airflow ({dot over (v)}) flowing into the living being and out of the living being,ascertaining from the detected respiration airflow ({dot over (v)}) whether an inhalation phase or an exhalation phase is provided,regulating an air pressure (p) in a respiratory organ of the living being,wherein, upon detecting the exhalation phase in the step of ascertaining, regulating the air pressure (p) in the respiratory organ in accordance with the respiration airflow ({dot over (v)}) of the exhalation or parameters derived therefrom so that the respiration airflow flowing out of the living being reaches a predetermined amount, andupon recognition of an exhalation phase in the step of ascertaining, raising the air pressure (p) in the respiratory organ at the beginning of the exhalation phase by applying a dynamically controlled counter pressure against the respiration airflow flowing out of the living being to increase a dynamic lung resistance in the living being. 16. Method according to claim 15, further comprising the step of increasing the air pressure (p) in the respiratory organ in the exhalation phase to a maximum pressure. 17. Method according to claim 15, further comprising the step of reducing the air pressure (p) in the respiratory organ in the exhalation phase at the end of the exhalation phase according to an essentially exponential decay function. 18. Method according to claim 15, further comprising the step of, upon recognition of an exhalation phase in the step of ascertaining, raising the air pressure (p) in the respiratory organ at the beginning of the exhalation phase. 19. Method according to claim 18, wherein the air pressure (p) in the respiratory organ is only regulated at the beginning of the exhalation phase as detected in the step of ascertaining so that the respiration airflow ({dot over (v)}) flowing out of the living being reaches a predetermined amount. 20. Method according to claim 15, wherein, in the exhalation phase as detected in the step of ascertaining, the air pressure (p) in the respiratory organ is regulated in proportion to the respiration airflow ({dot over (v)}) of the exhalation. 21. Method according to claim 15, wherein tidal volume is ascertained from the detected respiration airflow, further comprising the steps of: increasing the maximum value and/or the pressure level of the air pressure (p) in the respiratory organ in the exhalation phase and/or a pressure curve is adapted if an increase of the tidal volume is established in preceding respiration cycles. 22. Method according to claim 21, wherein the increase of the maximum value and/or the pressure level of the air pressure (p) in the respiratory element in the exhalation phase is limited to a highest value. 23. Method according to claim 15, further comprising the steps of: ascertaining the respiration frequency, andincreasing the maximum value and/or pressure level of the air pressure (p) in the respiratory organ in the exhalation phase, oradapting the pressure curve if a reduction of the respiratory frequency is established in preceding respiration cycles. 24. Method according to claim 15, further comprising the steps of: monitoring a time curve of the air pressure (p) and/or the respiration airflow ({dot over (v)}) in the respiratory organ for an occurrence of a superimposed oscillation having higher frequency than the respiration frequency, andincreasing the maximum value and/or the pressure level of the air pressure (p) in the respiratory organ in the exhalation phase, oradapting the pressure curve if a superimposed oscillation is recognized. 25. Method according to claim 15, further comprising the step of ascertaining an intrinsic PEEP (Positive End Expiratory Pressure-pressure level at the end of the exhalation phase) of the living being from the detected respiration airflow ({dot over (v)}) as a function of the pressure increase in the exhalation phase and the initial value of the air pressure in the respiratory organ (Po), is established in accordance with the intrinsic PEEP. 26. Method according to claim 25, further comprising the step of using the initial value of the air pressure in the respiratory organ as the basal pressure level (pa), which the pressure level does not fall below at any time, a basal pressure level (Po) being established as less than the intrinsic PEEP by a pressure differential value. 27. Method according to claim 15, wherein a regulatory cycle of the air pressure (p) in the respiratory organ comprises at least two respiration cycles, a respiration cycle comprising an inhalation phase and an exhalation phase, which directly follow one another.
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이 특허에 인용된 특허 (9)
Berthon Jones,Michael; Bateman,Peter; Malouf,Gordon, Adjustment of ventilator pressure-time profile to balance comfort and effectiveness.
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