Omega-3 enriched fish oil-in-water parenteral nutrition emulsions
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-035/60
A23D-009/013
A23D-007/00
A61K-031/202
A23D-007/005
A23D-007/01
A61K-009/00
A61K-009/107
A61K-036/286
A61K-036/47
A61K-047/14
A61K-047/22
A61K-047/24
A23P-020/12
A23L-029/10
A23L-033/00
A23L-033/115
A23L-033/12
A23L-033/17
출원번호
US-0715075
(2015-05-18)
등록번호
US-9642826
(2017-05-09)
발명자
/ 주소
Driscoll, David F.
출원인 / 주소
STABLE SOLUTIONS LLC
대리인 / 주소
Buchanan Ingersoll & Rooney PC
인용정보
피인용 횟수 :
0인용 특허 :
29
초록▼
An emulsion is provided including: an oil component and a water component, the oil component including: fish oil triglycerides in an amount of about 60% to about 90% based on the weight of the oil component; wherein the fish oil triglycerides include omega-3 fatty acids, expressed as triglycerides,
An emulsion is provided including: an oil component and a water component, the oil component including: fish oil triglycerides in an amount of about 60% to about 90% based on the weight of the oil component; wherein the fish oil triglycerides include omega-3 fatty acids, expressed as triglycerides, in an amount of at least 60%, based on the total weight of the fatty acids of the fish oil triglycerides; wherein the fish oil triglycerides include a total amount of EPA and DHA, expressed as triglycerides, of at least 45%, based on the total weight of the fatty acids of the fish oil triglycerides; and, at least one medium-chain triglyceride, wherein a total amount of the at least one medium-chain triglyceride is from about 10% to about 40% based on the weight of the oil component.
대표청구항▼
1. An emulsion comprising: an oil component and a water component, wherein the amount of the oil component in the emulsion is 5 to 30 g/100 mL, the oil component comprising: fish oil triglycerides in an amount of about 60% to about 90% based on the weight of the oil component; wherein the fish oil t
1. An emulsion comprising: an oil component and a water component, wherein the amount of the oil component in the emulsion is 5 to 30 g/100 mL, the oil component comprising: fish oil triglycerides in an amount of about 60% to about 90% based on the weight of the oil component; wherein the fish oil triglycerides comprise omega-3 fatty acids, expressed as triglycerides, in an amount of at least 60%, based on the total weight of the fatty acids of the fish oil triglycerides;wherein the fish oil triglycerides comprise a total amount of EPA and DHA, expressed as triglycerides, of at least 45%, based on the total weight of the fatty acids of the fish oil triglycerides; and,at least one medium-chain triglyceride oil, wherein a total amount of the at least one medium-chain triglyceride oil is from about 10% to about 40% based on the weight of the oil component,wherein the emulsion comprises an egg phospholipid present in a weight ratio of egg phospholipid to triglycerides ranging from 0.05 to 0.07. 2. The emulsion of claim 1, wherein the fish oil triglycerides are present in an amount of about 70% to about 90% based on the weight of the oil component of the emulsion. 3. The emulsion of claim 1, wherein the fish oil triglycerides are present in an amount of about 80% to about 90% based on the weight of the oil component of the emulsion. 4. The emulsion of claim 1, wherein the total amount of the at least one medium-chain triglyceride oil is from about 10% to about 30% based on the weight of the oil component of the emulsion. 5. The emulsion of claim 1, wherein the total amount of the at least one medium-chain triglyceride oil is from about 10% to about 20% based on the weight of the oil component of the emulsion. 6. The emulsion of claim 1, wherein the oil component is substantially free of myristic acid, palmitic acid and stearic acid. 7. The emulsion of claim 1, wherein the amount of the oil component in the emulsion is 5 g/100 mL to 17.5 g/100 mL, or the amount of the oil component in the emulsion is 22.5 g/100 mL to 30 g/100 mL. 8. The emulsion of claim 1, comprising α-tocopherol. 9. The emulsion of claim 1, comprising an omega-6 fatty acid-containing triglyceride. 10. The emulsion of claim 1, wherein the emulsion is physicochemically stable for at least 18 months. 11. The emulsion of claim 1, wherein the emulsion is physicochemically stable as an extemporaneously prepared syringe dosage for at least 12 hours at a temperature of 40° C. 12. The emulsion of claim 1, wherein the at least one medium-chain triglyceride oil comprises caprylic acid and capric acid, wherein the caprylic acid and capric acid constitute at least 90% by weight of the total content of the at least one medium-chain triglyceride oil. 13. The emulsion of claim 1, comprising a vegetable oil. 14. The emulsion of claim 13, wherein the vegetable oil is present in an amount of up to 10% based on the weight of the oil component of the emulsion. 15. The emulsion of claim 13, wherein the vegetable oil comprises a soybean oil, a safflower and/or a mixture thereof. 16. An emulsion comprising: an oil component and a water component, wherein the amount of the oil component in the emulsion is 5 to 30 g/100 mL, the oil component comprising: fish oil triglycerides in an amount of about 31% to about 90% based on the weight of the oil component; wherein the fish oil triglycerides comprise omega-3 fatty acids, expressed as triglycerides, in an amount of at least 60%, based on the total weight of the fatty acids of the fish oil triglycerides;wherein the fish oil triglycerides comprise a total amount of EPA and DHA, expressed as triglycerides, of at least 45%, based on the total weight of the fatty acids of the fish oil triglycerides; and,at least one medium-chain triglyceride oil, wherein a total amount of the at least one medium-chain triglyceride oil is from about 10% to about 69% based on the weight of the oil component,wherein the emulsion comprises an egg phospholipid present in a weight ratio of egg phospholipid to triglycerides ranging from 0.05 to 0.07. 17. The emulsion of claim 16, wherein the at least one medium-chain triglyceride oil comprises caprylic acid and capric acid, wherein the caprylic acid and capric acid constitute at least 90% by weight of the total content of the at least one medium-chain triglyceride oil. 18. A method of administering the emulsion of claim 1, comprising parenterally administering a dose of the emulsion to a human body. 19. A method for treating a human having a condition selected from the group consisting of a systemic inflammatory response syndrome, a respiratory distress syndrome, a nutritional and/or dietary cause of liver disease, an iatrogenic cause of liver disease, a pathological cause of liver disease, an immune modulation, head trauma, postoperative surgical stress, a myocardial infarction, cystic fibrosis and a combination thereof, said method comprising parenterally administering to said human an effective dosage amount of the emulsion of claim 1.
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